Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson's disease patients.

Autor: Stern S; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA. sstern@univ.haifa.ac.il.; Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel. sstern@univ.haifa.ac.il., Lau S; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA., Manole A; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA., Rosh I; Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel., Percia MM; Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel., Ben Ezer R; Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel., Shokhirev MN; Razavi Newman Integrative Genomics and Bioinformatics Core, Salk Institute for Biological Studies, La Jolla, CA, USA., Qiu F; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA., Schafer S; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA.; Department of Psychiatry, School of Medicine, Technical University of Munich, Munich, Germany., Mansour AA; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA.; Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Mangan KP; Fujifilm Cellular Dynamics, In, Madison, WI, 53711, USA., Stern T; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA.; Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel., Ofer P; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA.; Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel., Stern Y; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA.; Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel., Diniz Mendes AP; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA., Djamus J; Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel., Moore LR; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA., Nayak R; Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel., Laufer SH; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Aicher A; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA., Rhee A; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA., Wong TL; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA., Nguyen T; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA., Linker SB; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA., Winner B; Department of Stem Cell Biology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuernberg, Erlangen, Germany., Freitas BC; Fujifilm Cellular Dynamics, In, Madison, WI, 53711, USA., Jones E; Fujifilm Cellular Dynamics, In, Madison, WI, 53711, USA., Sagi I; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Bardy C; South Australian Health and Medical Research Institute (SAHMRI), Laboratory for Human Neurophysiology and Genetics, Adelaide, SA, Australia.; Flinders University, Flinders Health and Medical Research Institute (FHMRI), Adelaide, SA, Australia., Brice A; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, F-75013, Paris, France., Winkler J; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen- Nürnberg, Nürnberg, Germany., Marchetto MC; Department of Anthropology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA., Gage FH; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA. gage@salk.edu.

Publikováno v: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2022 Aug 10; Vol. 8 (1), pp. 103. Date of Electronic Publication: 2022 Aug 10.