Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Percent Injected Dose"'
Autor:
Alisa M. Posner, Robin Striar, Anna Kathryn Rattray, Rudolph E. Tanzi, Changning Wang, Tyler Nicholas Meyer, Sepideh Afshar, Ping Bai, Shiqian Shen, Yan Liu, Can Zhang, Yu Lan, Amelia G. Langan
Publikováno v:
J Med Chem
We report the development of the first positron emission tomography (PET) radiotracer, [(18)F]CNY-07, based on a highly specific and potent RIPK1 inhibitor, Nec-1s, for RIPK1/necroptosis brain imaging in rodents. [(18)F]CNY-07 was synthesized through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c6846c1adf50b54d2cda4841ca2da5
https://doi.org/10.1021/acs.jmedchem.1c01477
https://doi.org/10.1021/acs.jmedchem.1c01477
Publikováno v:
Amino Acids. 53:929-938
Facile automatic production is important for the application of prostate-specific membrane antigen (PSMA) tracers in clinical practice. We developed a new 18F-AlF-labelled PSMA probe—18F-AlF-PSMA-NF—and explore its automated production method and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee6c777bb518cf67b9f83c8aeb835f52
https://doi.org/10.1007/s00726-021-02997-7
https://doi.org/10.1007/s00726-021-02997-7
Autor:
Maha M. Amin, Mohamed Y. Zakaria, Shady M. Abd El-halim, Ahmed B. Ibrahim, Ghada A. Abdelbary, Hesham A. Shamsel-Din
Publikováno v:
Daru
Purpose Adefovir dipivoxil (AD), a nucleoside reverse transcriptase inhibitor is effective against Hepatitis B virus. Its poor oral bioavailability leads to frequent administration causing severe adverse effects. Thereby the entrapment of AD within l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175448d3ee3162be4c4e1dfaf42cedd7
https://doi.org/10.1007/s40199-020-00355-8
https://doi.org/10.1007/s40199-020-00355-8
Autor:
Tina Zelonina, Monica P. Goldklang, Lynne L. Johnson, Kyle Stearns, Jeanine D'Armiento, Rui Xiao, Yared Tekabe, Jordis Trischler, Alexander Shields, Krissy Rodriguez, Alexander Romanov
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-9 (2019)
Respiratory Research
Respiratory Research
Background Expression of the Receptor for Advanced Glycation Endproducts (RAGE) initiates pro-inflammatory pathways resulting in lung destruction. We hypothesized that RAGE directed imaging demonstrates increased lung uptake in smoke-exposure. Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d198ed172ab81f5617b9b5e7079547
http://link.springer.com/article/10.1186/s12931-019-1064-4
http://link.springer.com/article/10.1186/s12931-019-1064-4
Autor:
Miki Goto, Yasuyoshi Watanabe, Satsuki Irie, Ken-ichi Kaneko, Yasuhiro Wada, Kazuaki Kasai, Hisashi Doi, Kei Mizuno, Satoshi Nozaki, Fujii Kenji, Emi Hayashinaka, Akira Nishiyama, Kenji Mizuseki, Kyosuke Watanabe
Publikováno v:
Biochemical and Biophysical Research Communications. 512:611-615
Coenzyme Q10 (CoQ10) plays a key role not only as an essential electron carrier in the mitochondrial electron transport chain, but also as an antioxidant to protect cells from oxidative stress. CoQ10 supplementation is expected to be effective for a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::927dd0618182aedd5ec7875b874cfb1f
https://doi.org/10.1016/j.bbrc.2019.03.073
https://doi.org/10.1016/j.bbrc.2019.03.073
Publikováno v:
Molecular Imaging and Biology. 21:1089-1096
2-Deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) has been widely used for imaging brain metabolism. Tracer injection in anesthetized animals is a prerequisite for performing dynamic positron emission tomography (PET) scanning. Since preconditioning, as wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd95cac72438be88b12b2e9271b2436b
https://doi.org/10.1007/s11307-019-01314-9
https://doi.org/10.1007/s11307-019-01314-9
Autor:
Hideki Kawai, Artiom Petrov, Aditya Shekhar, Takashi Tanimoto, Takehiro Nakahara, Frank D. Kolodgie, Jiqiu Chen, Partho P. Sengupta, Renu Virmani, Jagat Narula, Harry Strauss, Koon Y. Pak, Djamel Lebeche, Francis G. Blankenberg, Farhan Chaudhry, Navneet Narula, Roger J. Hajjar, Dongbin Kim
Publikováno v:
JACC: Cardiovascular Imaging. 11:1823-1833
Objectives The purpose of this study was to evaluate the feasibility of imaging apoptosis in experimental ischemia-reperfusion model by technetium-99m (99mTc)-labeled Duramycin, and compare it to an established tracer, 99mTc-labeled Annexin-V, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06f2d50d53afda7e3e3b6db1ae0d94ad
https://doi.org/10.1016/j.jcmg.2017.11.037
https://doi.org/10.1016/j.jcmg.2017.11.037
Autor:
Hideki Kawai, Valentin Fuster, Francis G. Blankenberg, Takashi Tanimoto, Phillip D. Levy, Dongbin Kim, Jeffrey A. Mattis, Jagat Narula, Aditya Shekhar, H. William Strauss, Fayzan Chaudhry, Farhan Chaudhry, Yukio Ozaki, Navneet Narula, Eloisa Arbustini, Artiom Petrov, Koon Y. Pak, Matthew K.M.Y. Adapoe, Kipp W. Johnson, Takehiro Nakahara
Publikováno v:
Journal of the American College of Cardiology. 76(16)
Background Apoptosis in atherosclerotic lesions contributes to plaque vulnerability by lipid core enlargement and fibrous cap attenuation. Apoptosis is associated with exteriorization of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074c363f17b777d0867a5388f88d841c
https://pubmed.ncbi.nlm.nih.gov/33059833
https://pubmed.ncbi.nlm.nih.gov/33059833
Autor:
William C. Zamboni, Allison M. Deal, Lauren S.L. Price, Stephan T. Stern, Alexander V. Kabanov
Publikováno v:
Science Advances
Interpretation of nanoparticle PK results can be markedly influenced by differing PK metrics selected.
Nanoparticle (NP) delivery to solid tumors has recently been questioned. To better understand the magnitude of NP tumor delivery, we reanalyze
Nanoparticle (NP) delivery to solid tumors has recently been questioned. To better understand the magnitude of NP tumor delivery, we reanalyze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3b1172fda7d5d40b8df0f3b6b62e3a
http://europepmc.org/articles/PMC7439617
http://europepmc.org/articles/PMC7439617
Autor:
Elaheh Khozeimeh Sarbisheh, Delphine Vivier, Eric W. Price, Outi Keinänen, Kimberly Fung, Brian M. Zeglis
Publikováno v:
Molecules, Vol 25, Iss 2315, p 2315 (2020)
Molecules
Volume 25
Issue 10
Molecules
Volume 25
Issue 10
High expression levels of the tumor-associated antigen MUC1 have been correlated with tumor aggressiveness, poor response to therapy, and poor survival in several tumor types, including breast, pancreatic, and epithelial ovarian cancer. Herein, we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472ae57cdb9f0589cede30d5cb516141
https://www.mdpi.com/1420-3049/25/10/2315
https://www.mdpi.com/1420-3049/25/10/2315