Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity.

Autor: Tavella TA; Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil., da Silva NSM; Biochemistry and Biophysics of Proteins Group-São Carlos Institute of Chemistry-IQSC, University of São Paulo, Trabalhador Sancarlense Avenue, 400, BQ1, S27, São Carlos, SP 13566-590, Brazil., Spillman N; Department of Biochemistry, Bio 21 Institute, University of Melbourne, 30 Flemington Rd, Parkville, Melbourne,VIC 3052, Australia., Kayano ACAV; Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil., Cassiano GC; Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil.; Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1099-085 Lisboa, Portugal., Vasconcelos AA; Laboratory of Genomics and BioEnergy, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil., Camargo AP; Laboratory of Genomics and BioEnergy, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil., da Silva DCB; Leônidas & Maria Deane Institute, Fundação Oswaldo Cruz-FIOCRUZ, Manaus , AM 69057070, Brazil.; Fundação de Medicina Tropical-Dr. Heitor Vieira Dourado, Manaus, AM 69040-000, Brazil., Fontinha D; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-004 Lisboa, Portugal., Salazar Alvarez LC; Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil., Ferreira LT; Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil., Peralis Tomaz KC; Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil., Neves BJ; Laboratory of Molecular Modeling and Drug Design, LabMol, Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO 74605-170, Brazil.; LabChem-Laboratory of Cheminformatics, Centro Universitário de Anápolis-UniEVANGÉLICA, Anápolis, GO 75083-515, Brazil., Almeida LD; Synthetic Biology Laboratory, Department of Structural and Functional Biology, Institute of Biology, UNICAMP, Campinas, SP Brazil., Bargieri DY; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, Cidade Universitária 'Armando Salles Oliveira', São Paulo 05508-000, Brazil., Lacerda MVG; Fundação de Medicina Tropical-Dr. Heitor Vieira Dourado, Manaus, AM 69040-000, Brazil., Lemos Cravo PV; LabChem-Laboratory of Cheminformatics, Centro Universitário de Anápolis-UniEVANGÉLICA, Anápolis, GO 75083-515, Brazil.; Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1099-085 Lisboa, Portugal., Sunnerhagen P; Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30 Gothenburg, Sweden., Prudêncio M; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-004 Lisboa, Portugal., Andrade CH; Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil.; Laboratory of Molecular Modeling and Drug Design, LabMol, Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO 74605-170, Brazil., Pinto Lopes SC; Leônidas & Maria Deane Institute, Fundação Oswaldo Cruz-FIOCRUZ, Manaus , AM 69057070, Brazil.; Fundação de Medicina Tropical-Dr. Heitor Vieira Dourado, Manaus, AM 69040-000, Brazil., Carazzolle MF; Laboratory of Genomics and BioEnergy, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil., Tilley L; Department of Biochemistry, Bio 21 Institute, University of Melbourne, 30 Flemington Rd, Parkville, Melbourne,VIC 3052, Australia., Bilsland E; Synthetic Biology Laboratory, Department of Structural and Functional Biology, Institute of Biology, UNICAMP, Campinas, SP Brazil., Borges JC; Biochemistry and Biophysics of Proteins Group-São Carlos Institute of Chemistry-IQSC, University of São Paulo, Trabalhador Sancarlense Avenue, 400, BQ1, S27, São Carlos, SP 13566-590, Brazil., Maranhão-Costa FTM; Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP 13083-970, Brazil.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2021 Apr 09; Vol. 7 (4), pp. 759-776. Date of Electronic Publication: 2021 Mar 10.