Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Per-Olov Eriksson"'
Autor:
Kristofer Eriksson, Veronique Chotteau, Hubert Schwarz, Nils Arnold Brechmann, Per-Olov Eriksson, Atefeh Shokri
Publikováno v:
Biotechnology and Bioengineering. 118:3499-3510
Cell clarification represents a major challenge for the intensification through very high cell density in the production of biopharmaceuticals such as monoclonal antibodies (mAbs). The present report proposes a solution to this challenge in a streaml
Autor:
Nils A. Brechmann, Hubert Schwarz, Per‐Olov Eriksson, Kristofer Eriksson, Atefeh Shokri, Véronique Chotteau
Publikováno v:
Biotechnology and Bioengineering. 118
Publikováno v:
Journal of Biotechnology. 141:64-72
A novel crossflow filtration methodology is demonstrated for the initial purification of the therapeutic protein, promegapoietin-1a (PMP), produced as inclusion bodies (IBs) in a recombinant Escherichia coli bioprocess. Two strategic separation steps