Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Per-Georg Nyholm"'
Autor:
Barbro Ek-Rylander, Martin Haraldsson, Anja Reithmeier, Martin Frank, Thomas Lundbäck, Per-Georg Nyholm, Anna-Lena Gustavsson, Göran Andersson
Publikováno v:
Chemical biologydrug design. 92(1)
Tartrate-resistant acid phosphatase (TRAP/ACP5) occurs as two isoforms-TRAP 5a with low enzymatic activity due to a loop interacting with the active site and the more active TRAP isoform 5b generated upon proteolytic cleavage of this loop. TRAP has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c50ac4de74a113c365f8fddd9c4fb2
https://pubmed.ncbi.nlm.nih.gov/29500863
https://pubmed.ncbi.nlm.nih.gov/29500863
Autor:
Göran Larson, Waqas Nasir, Martin Frank, Angelika Kunze, Marta Bally, Per-Georg Nyholm, Fredrik Höök, Francisco Parra
Publikováno v:
ACS chemical biology. 12(5)
Virus entry depends on biomolecular recognition at the surface of cell membranes. In the case of glycolipid receptors, these events are expected to be influenced by how the glycan epitope close to the membrane is presented to the virus. This presenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ed009756df400eacdc9e2d69f3a8ed
https://pubmed.ncbi.nlm.nih.gov/28294600
https://pubmed.ncbi.nlm.nih.gov/28294600
Publikováno v:
Journal of Computer-Aided Molecular Design. 29:13-21
Accurate estimation of protein-carbohydrate binding energies using computational methods is a challenging task. Here we report the use of expanded ensemble molecular dynamics (EEMD) simulation with double decoupling for estimation of binding energies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae40b73a0418401cd6793c64084c4719
https://doi.org/10.1007/s10822-014-9792-5
https://doi.org/10.1007/s10822-014-9792-5
Publikováno v:
Journal of Chemical Information and Modeling. 53:2559-2570
Computing binding energies of protein-ligand complexes including their enthalpy and entropy terms by means of computational methods is an appealing approach for selecting initial hits and for further optimization in early stages of drug discovery. De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e1582776801224aeab62bc124b97c0
https://doi.org/10.1021/ci400321r
https://doi.org/10.1021/ci400321r
Autor:
Per-Georg Nyholm, Nopparat Srakaew, Chaitanya A. K. Koppisetty, Euridice Carmona, Nongnuj Tanphaichitr, Hongbin Xu, Fang Liu
Publikováno v:
REPRODUCTION. 144:209-219
We have shown previously that sperm surface arylsulfatase A (ASA) of mouse, pig, and human is involved in sperm–egg zona pellucida (ZP) binding. By treating capacitated mouse sperm with A23187 to induce the acrosome reaction, we demonstrated by imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea39351e39fcfe51c075835284276c9
https://doi.org/10.1530/rep-11-0338
https://doi.org/10.1530/rep-11-0338
Autor:
Francesco Strino, Göran Larson, Waqas Nasir, Per-Georg Nyholm, Gustaf E. Rydell, Chaitanya A. K. Koppisetty
Publikováno v:
Journal of Computer-Aided Molecular Design. 24:423-431
Norovirus strains are known to cause recurring epidemics of winter vomiting disease. The crystal structure of the capsid protein of VA387, a representative of the clinically important GII.4 genocluster, was recently solved in complex with histo-blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe477ddd2e99baf0d3aa91b5529b15cf
https://doi.org/10.1007/s10822-010-9353-5
https://doi.org/10.1007/s10822-010-9353-5
Publikováno v:
Journal of Computer-Aided Molecular Design. 23:845-852
Histo-blood group ABH antigens serve as recognition sites for infectious microorganisms and tissue lectins in intercellular communication, e.g. in tumor progression. Thus, they are of interest as a starting point for drug design. In this respect, pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d77cbf3558d48f5c96f1c22c7cc54b6
https://doi.org/10.1007/s10822-009-9301-4
https://doi.org/10.1007/s10822-009-9301-4
Autor:
Martin Frank, Barbro Ek-Rylander, Teresa Senge, Göran Andersson, Michael Krumpel, Per-Georg Nyholm, Toni Andreas Baeumler, Anja Reithmeier
Publikováno v:
Experimental cell research. 339(1)
Tartrate-resistant acid phosphatase (TRAP/ACP5/uteroferrin/purple acid phosphatase/PP5) has received considerable attention as a newly discovered proinvasion metastasis driver associated with different malignancies. This renders TRAP an interesting t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70aea98098beaa480c2850e5c54ce6c
https://pubmed.ncbi.nlm.nih.gov/26428664
https://pubmed.ncbi.nlm.nih.gov/26428664
Autor:
Kamil Seyrek, Fred Sinowatz, Hans-Joachim Gabius, Hans-Christian Siebert, Per-Georg Nyholm, Herbert Kaltner, Nicolai V. Bovin, Jimmy Rosen, Sabine André
Publikováno v:
Biochimie. 88:399-410
The glycan part endows cellular glycoconjugates with significant potential for biological recognition. N-Glycan branches often end with alpha2,3/alpha2,6-sialylation, posing the question whether and how placement of the sialic acid at 3 - or 6 -accep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd82e9a9ea4cc1227ce2df91551bf056
https://doi.org/10.1016/j.biochi.2005.09.006
https://doi.org/10.1016/j.biochi.2005.09.006
Publikováno v:
Carbohydrate Research. 340:1059-1064
We have implemented a system called glygal that can perform conformational searches on oligosaccharides using several different genetic algorithm (GA) search methods. The searches are performed in the torsion angle conformational space, considering b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5964171b3625de48a41466924d9bc3
https://doi.org/10.1016/j.carres.2004.12.037
https://doi.org/10.1016/j.carres.2004.12.037