Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Per-Eric Lund"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Glucagon is elevated Type-2 diabetes, which contributes to poor glucose control in patients with the disease. Here the authors report that secretion of the hormone is controlled by paracrine inhibition, and that resistance of α-cells to somatostatin
Externí odkaz:
https://doaj.org/article/e632b127eee5439face77166a636f601
Autor:
Ewelina Golec, Alexander Ekström, Maciej Noga, Muhmmad Omar-Hmeadi, Per-Eric Lund, Bruno O. Villoutreix, Ulrika Krus, Katarzyna Wozniak, Olle Korsgren, Erik Renström, Sebastian Barg, Ben C. King, Anna M. Blom
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(24)
Human pancreatic islets highly express CD59, which is a glycosylphosphatidylinositol (GPI)-anchored cell-surface protein and is required for insulin secretion. How cell-surface CD59 could interact with intracellular exocytotic machinery has so far no
Autor:
Timo Otonkoski, Tom Barsby, Joey Lau, Pekka Katajisto, Sebastian Barg, Anders Tengholm, Diego Balboa, Jouni Kvist, Hossam Montaser, Anni I. Nieminen, Eija Jokitalo, Per-Ola Carlsson, Mingyu Yang, Chandra, Lithovius, Dyachok O, Kuuluvainen E, Per-Eric Lund, Jonna Saarimäki-Vire, Jarkko Ustinov, Helena Vihinen, Näätänen A, Muhmmad Omar-Hmeadi, Hietakangas, Hazem Ibrahim
Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a promising treatment for diabetes. Despite progress in stem cell-derived islet (SC-islet) generation, detailed characterization of their functional properties has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d064cd6493b091037674586fc069fb8e
https://doi.org/10.1101/2021.03.31.437748
https://doi.org/10.1101/2021.03.31.437748
Publikováno v:
The Journal of General Physiology
There exist many different ion channel modulators that inhibit channel function, but few that increase it. Liin et al. tested 18,000 compounds by high-throughput electrophysiology and found several channel openers with a biaryl-sulfonamide motif that
Publikováno v:
Biophysical Journal. 120:51a
Publikováno v:
Pharmaceutical Research. 30:1409-1422
In vivo and ex vivo inhibition of ectopic activity of clinically used and newly developed sodium channel (NaV) blockers were quantified in the rat spinal nerve ligation (SNL) model using a pharmacokinetic-pharmacodynamic (PKPD) approach and correlate
Autor:
Michael Dabrowski, Olga Babich, Olof Larsson, Per-Eric Lund, Giannoula Klement, Zara A. Sands, Asa Malmberg, Lars Sandberg
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 15:713-720
Congenital Insensitivity to Pain (CIP) is a loss of function mutation resulting in a truncated NaV1.7 protein, suggesting a pivotal role in pain signaling and rendering it an important pharmaceutical target for multiple pain conditions. The structura
Autor:
Tjerk Bueters, Gabor Csjernyik, Nilsson Linda I, Per-Eric Lund, Yevgeni Besidski, Istvan Macsari, Per I. Arvidsson, Ulrika Yngve, Sandra Oerther, Kristofer Åhlin, Lars Sandberg, Karin Hygge Blakeman, Lei Luo, Anders B. Eriksson, Elisabet Venyike
Publikováno v:
Journal of Medicinal Chemistry. 55:6866-6880
The voltage-gated sodium channel Na(V)1.7 is believed to be a critical mediator of pain sensation based on clinical genetic studies and pharmacological results. Clinical utility of nonselective sodium channel blockers is limited due to serious advers
Autor:
Tobias Ginman, Elisabet Venyike, Tjerk Bueters, Istvan Macsari, Lars Sandberg, Anders B. Eriksson, Yevgeni Besidski, Ylva Gravenfors, Per-Eric Lund, Johan Bylund, Per I. Arvidsson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3871-3876
Blocking of certain sodium channels is considered to be an attractive mechanism to treat chronic pain conditions. Phenyl isoxazole carbamate 1 was identified as a potent and selective Na(V)1.7 blocker. Structural analogues of 1, both carbamates, urea
Autor:
Per-Eric Lund, Olof Larsson, Michael Dabrowski, Jon Sinclair, Johannes J. Krupp, Kim Dekermendjian
Publikováno v:
CNS & Neurological Disorders - Drug Targets. 7:122-128
Ion channels are at present the third biggest target class in drug discovery. Primary research is continually uncovering potential new ion channel targets in indications such as cancer, diabetes and respiratory diseases, as well as the more establish