Structural Modifications and Biological Evaluations of Rift Valley Fever Virus Inhibitors Identified from Chemical Library Screening

Autor: Koushikul Islam, Marcus Carlsson, Per-Anders Enquist, Weixing Qian, Marko Marttila, Mårten Strand, Clas Ahlm, Magnus Evander

Publikováno v: ACS Omega, Vol 7, Iss 8, Pp 6854-6868 (2022)

Externí odkaz: https://doaj.org/article/335fc04f9e4c46ceb8978af430769506

Selective auxin agonists induce specific AUX/IAA protein degradation to modulate plant development

Autor: Małgorzata Łangowska, Thomas Vain, Alexandre Ismail, Stefan Kepinski, Mattias Thelander, Adeline Rigal, Martin Kieffer, Sara Raggi, Karin Ljung, Ondřej Novák, Sigurd Ramans Harborough, Qian Ma, Barbora Pařízková, Mark Estelle, Noel Ferro, Yi Zhang, Fredrik Almqvist, Siamsa M. Doyle, Deepak Kumar Barange, Laurens Pauwels, Per Anders Enquist, Stéphanie Robert, Judy Callis

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 13

Significance The plant hormone auxin coordinates almost all aspects of plant development. Throughout plant life, the expression of hundreds of genes involved in auxin regulation is orchestrated via several combinatorial and cell-specific auxin percep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c505202e3769275d39f6c2c8ef4468b
https://eprints.whiterose.ac.uk/143942/7/1809037116.full.pdf

Identification of a small molecule that stabilizes lipoprotein lipase in vitro and lowers triglycerides in vivo

Autor: Mikael Elofsson, Per-Anders Enquist, Madelene Ericsson, Stefan K. Nilsson, Rémi Caraballo, Gunilla Olivecrona, Aivar Lookene, Mikael Larsson

Publikováno v: Biochemical and Biophysical Research Communications. 450:1063-1069

Patients at increased cardiovascular risk commonly display high levels of plasma triglycerides (TGs), elevated LDL cholesterol, small dense LDL particles and low levels of HDL-cholesterol. Many remain at high risk even after successful statin therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c9fc9fc6c879cec1acf6b70ab3700c
https://doi.org/10.1016/j.bbrc.2014.06.114

Small-Molecule Screening Using a Whole-Cell Viral Replication Reporter Gene Assay Identifies 2-{[2-(Benzoylamino)Benzoyl]Amino}-Benzoic Acid as a Novel Antiadenoviral Compound

Autor: Annika Allard, Ma ûrten Strand, Karin Edlund, Per-Anders Enquist, Kristina Lindman, Ya-Fang Mei, Sara Spjut, Göran Wadell, Emma Andersson, Mikael Elofsson

Publikováno v: Antimicrobial Agents and Chemotherapy. 54:3871-3877

Adenovirus infections are widespread in society and are occasionally associated with severe, but rarely with life-threatening, disease in otherwise healthy individuals. In contrast, adenovirus infections present a real threat to immunocompromised ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e954720f0718ecce777f8c6f28c307ca
https://doi.org/10.1128/aac.00203-10

Reversal of the Antichlamydial Activity of Putative Type III Secretion Inhibitors by Iron

Autor: Anatoly Slepenkin, Mikael Elofsson, Ellena M. Peterson, Ulrik Hägglund, Per-Anders Enquist, Luis M. de la Maza

Publikováno v: Infection and Immunity. 75:3478-3489

INPs, which are chemically synthesized compounds belonging to a class of acylated hydrazones of salicylaldehydes, can inhibit the growth of Chlamydiaceae . Evidence has been presented that in Yersinia and Chlamydia INPs may affect the type III secret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6c5e3b30612748d5bb282564eaba1b
https://doi.org/10.1128/iai.00023-07