Výsledky vyhledávání

An Enantioselective Hydrogenation of an Alkenoic Acid as a Key Step in the Synthesis of AZD2716

Autor: Staffan Karlsson, Søren M. Andersen, Henrik Toft Sørensen, Angele Cruz, Per Ryberg

Publikováno v: Organic Process Research & Development. 20:262-269

A classical resolution of a racemic carboxylic acid through salt formation and an asymmetric hydrogenation of an α,β-unsaturated carboxylic acid were investigated in parallel to prepare an enantiomerically pure alkanoic acid used as a key intermedi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d180a740f82147ac3a1cb85a5513100
https://doi.org/10.1021/acs.oprd.5b00382

Zobrazit plný text záznamu

Asymmetric Reduction of Lactam-based β-Aminoacrylates. Synthesis of Heterocyclic β2-Amino Acids

Autor: Timothy Gallagher, Per Ryberg, Jeremy S. Parker, Perry Matthew, Hugo Rego Campello

Publikováno v: Rego Campello, H, Parker, J S, Perry, M W D, Ryberg, P & Gallagher, T 2016, ' Asymmetric Reduction of Lactam-based β-Aminoacrylates. Synthesis of Heterocyclic β2-Amino Acids ', Organic Letters, vol. 18, no. 16, pp. 4124–4127 . https://doi.org/10.1021/acs.orglett.6b02074

The ability to affect asymmetric reduction of heterocyclic β-aminoacrylates 1 (n = 1-3) has been assessed with pyrrolidine and piperidone variants generating the corresponding N-heterocyclic β(2)-amino acids 3b and 5b with high enantioselectivity (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e572362f0b25ce20564d8b902f6a34
https://research-information.bris.ac.uk/en/publications/4efa0b39-5175-41c0-bebf-fdd3ca7316c2

Zobrazit plný text záznamu

High Throughput Screening of a Catalyst Library for the Asymmetric Transfer Hydrogenation of Heteroaromatic Ketones: Formal Syntheses of (R)-Fluoxetine and (S)-Duloxetine

Autor: Helena Lundberg, Hans Andersson, Per Ryberg, Hans Adolfsson, Elina Buitrago

Publikováno v: ChemCatChem. 4:2082-2089

A total of 21 amino acid based ligands including hydroxy amide, thioamide, and hydroxamic acid functionalities, respectively, were combined with [Ru(p-cymene)Cl2]2 and [RhCp*Cl2]2, and used as cata ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f154d948aca8cb5e8fe34ace10e189d3
https://doi.org/10.1002/cctc.201200308

Zobrazit plný text záznamu

Development of a Mild and Robust Method for Large-Scale Palladium-Catalysed Cyanation of Aryl Bromides: Importance of the Order of Addition

Autor: Per Ryberg

Publikováno v: Organic Process Research & Development. 12:540-543

A mild and robust method for the large-scale palladium-catalysed cyanation of aryl bromides has been developed. The reaction is sensitive to cyanide poisoning of the catalyst, and it was found that the order of adding the reagents had a strong impact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d9a819f56bdb0ac2f798b964e79e665
https://doi.org/10.1021/op800020r

Zobrazit plný text záznamu

ChemInform Abstract: Rhodium-Catalyzed Enantioselective Silylation of Arene C-H Bonds: Desymmetrization of Diarylmethanols

Autor: Robert Berg, Per Ryberg, Taegyo Lee, John F. Hartwig, Tyler W. Wilson

Publikováno v: ChemInform. 46

The hydrosilylation of symmetrical benzophenones (II) and (X) with diethylsilane followed by Rh-catalyzed asymmetric intramolecular silylation gives rise to chiral benzoxasiloles (IV) and (XI), respectively.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfe503ebf87d2fd9272ca57eb491dec6
https://doi.org/10.1002/chin.201548185

Zobrazit plný text záznamu

Rhodium-Catalyzed Enantioselective Silylation of Arene C–H Bonds: Desymmetrization of Diarylmethanols

Autor: John F. Hartwig, Robert Berg, Taegyo Lee, Tyler W. Wilson, Per Ryberg

Publikováno v: Journal of the American Chemical Society, vol 137, iss 21

We report a Rh-catalyzed, enantioselective silylation of arene C–H bonds directed by a (hydrido)silyl group. (Hydrido)silyl ethers that are formed in situ by hydrosilylation of benzophenone or its derivatives undergo asymmetric C–H silylation in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a97cc65b5782ef9676f45d6acb8e1d
https://europepmc.org/articles/PMC4699421/

Zobrazit plný text záznamu

Reevaluation of the Mechanism of the Amination of Aryl Halides Catalyzed by BINAP-Ligated Palladium Complexes

Autor: Per Ryberg, Shashank Shekhar, Jinu S. Mathew, Eric R. Strieter, Donna G. Blackmond, John F. Hartwig, Stephen L. Buchwald

Publikováno v: Journal of the American Chemical Society. 128:3584-3591

Two previous mechanistic studies of the amination of aryl halides catalyzed by palladium complexes of 1,1'-binaphthalene-2,2'-diylbis(diphenylphosphine) (BINAP) are reexamined by the authors of both studies. This current work includes a detailed stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c815cd12a17603a9f0119816931961
https://doi.org/10.1021/ja045533c

Zobrazit plný text záznamu

Oxidative Addition of Phenyl Bromide to Pd(BINAP) vs Pd(BINAP)(amine). Evidence for Addition to Pd(BINAP)

Autor: John F. Hartwig, Per Ryberg, Shashank Shekhar

Publikováno v: Organic Letters. 8:851-854

The rates of oxidative addition of phenyl bromide to [Pd(BINAP)2] have been measured in the presence and absence of added amine to assess a previous hypothesis that addition to [Pd(BINAP)(amine)] is faster than addition to [Pd(BINAP)]. These data sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1be6e05f75fd1ccd9b8b1d2c2f46397
https://doi.org/10.1021/ol0528890

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání