Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Per Lundmark"'
Autor:
Jonas Carlsson Almlöf, Per Lundmark, Anders Lundmark, Bing Ge, Tomi Pastinen, Cardiogenics Consortium, Alison H Goodall, François Cambien, Panos Deloukas, Willem H Ouwehand, Ann-Christine Syvänen
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102612 (2014)
We applied genome-wide allele-specific expression analysis of monocytes from 188 samples. Monocytes were purified from white blood cells of healthy blood donors to detect cis-acting genetic variation that regulates the expression of long non-coding R
Externí odkaz:
https://doaj.org/article/2e9d9228294a404dafb5b8b1a3ce4588
Autor:
Jonas Carlsson Almlöf, Per Lundmark, Anders Lundmark, Bing Ge, Seraya Maouche, Harald H H Göring, Ulrika Liljedahl, Camilla Enström, Jessy Brocheton, Carole Proust, Tiphaine Godefroy, Jennifer G Sambrook, Jennifer Jolley, Abigail Crisp-Hihn, Nicola Foad, Heather Lloyd-Jones, Jonathan Stephens, Rhian Gwilliam, Catherine M Rice, Christian Hengstenberg, Nilesh J Samani, Jeanette Erdmann, Heribert Schunkert, Tomi Pastinen, Panos Deloukas, Alison H Goodall, Willem H Ouwehand, François Cambien, Ann-Christine Syvänen
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52260 (2012)
A large number of genome-wide association studies have been performed during the past five years to identify associations between SNPs and human complex diseases and traits. The assignment of a functional role for the identified disease-associated SN
Externí odkaz:
https://doaj.org/article/d0a286581c23430fa9c2b3d1ada6f11f
Publikováno v:
PLoS ONE, Vol 3, Iss 3, p e1807 (2008)
Human body height is a complex genetic trait with high heritability. We performed an association study of 17 candidate genes for height in the Uppsala Longitudinal Study of Adult Men (ULSAM) that consists of 1153 elderly men of age 70 born in the cen
Externí odkaz:
https://doaj.org/article/7ece732515c84ed785ba0854a5bfea92
Publikováno v:
Acta Physiologica. 208:88-94
Aim Indirect evidences by blockade of the endothelin receptors have suggested a role of endothelin in endothelium-dependent vasodilation. This study aimed to investigate whether circulating levels of endotehlin-1 or genetic variations in genes in the
Autor:
Benjamin F. Voight, Andrew D. Morris, G. Kees Hovingh, Anthony J. Balmforth, Hanneke Basart, Alistair S. Hall, Dominique Gauguier, Bok Ghee Han, Martina Müller-Nurasyid, Sarah Parish, Jarmo Virtamo, Christa Meisinger, Peter Wagner, George Dedoussis, Philipp S. Wild, Kari Stefansson, Jean-Baptiste Cazier, Kathleen Stirrups, Jiyoung Lee, Adrienne Cupples, Stavroula Kanoni, Danish Saleheen, Christian Hengstenberg, Svati H. Shah, Panos Deloukas, Anuj Goel, Stefan Blankenberg, Sian Tsung Tan, Alison H. Goodall, Tõnu Esko, Eric Boerwinkle, Gudmundur Thorgeirsson, Peter S. Braund, Joshua W. Knowles, Olle Melander, C. Ellen van der Schoot, Silke Rosinger, Maria Dimitriou, Wolfgang Koenig, Michael Boehnke, François Cambien, Per Lundmark, Dmitry Shungin, Wolfgang Kratzer, Pierre Zalloua, Reijo Laaksonen, Jean Ferrières, Villi Gudnason, Thorsten Kessler, Daniel J. Rader, Niclas Eriksson, Dominique Arveiler, Natalie R. van Zuydam, Kari Kuulasmaa, N. William Rayner, Sarah E. Hunt, Gudmar Thorleifsson, Jeanette Erdmann, Samuli Ripatti, Tsun-Po Yang, George A. Wells, Terho Lehtimäki, Kjell Nikus, Pierre Fontanillas, Jorg Hager, Martin Farrall, Jemma C. Hopewell, Frank Kee, Juha Sinisalo, Christopher J. O'Donnell, Asif Rasheed, Mika Kähönen, Genovefa Kolovou, Seraya Maouche, Suzanne Rafelt, Cordelia Langford, Winfried März, Leo-Pekka Lyytikäinen, Christina Willenborg, Weihua Zhang, Kati Kristiansson, Hyo-Soo Kim, Weang K. Ho, Jeong E. Park, Mohan U. Sivananthan, Moritz P. Rumpf, Markku Laakso, Klaus Stark, Philippe Amouyel, Paul W. Franks, Andres Metspalu, Anders Franco-Cereceda, Manjinder S. Sandhu, Nour Eddine El Mokhtari, Nicholas J. Wareham, Robert Roberts, Veikko Salomaa, Thomas Illig, Tomi Pastinen, Robert Clarke, Christof Burgdorf, Leif Groop, Devin Absher, Yangsoo Jang, Mark I. McCarthy, Bernhard O. Boehm, Per Eriksson, Nilesh J. Samani, Inke R. König, Stefan Schreiber, Karin Leander, Simone Claudi-Boehm, Ci Song, Benjamin A. Goldstein, Stephen E. Epstein, Andreas Ziegler, Stanley L. Hazen, Arne Schäfer, Elin Grundberg, Sekar Kathiresan, John R. Thompson, Unnur Thorsteinsdottir, Muredach P. Reilly, Heribert Schunkert, Rory Collins, Thomas Quertermous, Jong-Young Lee, John Danesh, John C. Chambers, Marco M Ferrario, Carlos Iribarren, Claudia Langenberg, Hilma Holm, Rona J. Strawbridge, Alan S. Go, Cristen J. Willer, Ron Do, Emmi Tikkanen, Abbas Dehghan, Evelin Mihailov, Lindsay L. Waite, Patrick Diemert, Willem H. Ouwehand, Eric E. Schadt, Diana Rubin, David Altshuler, Marcus E. Kleber, Markus Perola, Alexandre F.R. Stewart, Jaspal S. Kooner, Themistocles L. Assimes, Inês Barroso, Bruna Gigante, Göran Hallmans, Marja-Liisa Lokki, Aki S. Havulinna, Anders Hamsten, Agneta Siegbahn, Lasse Folkersen, Erik Ingelsson, Martina E. Zimmermann, Colin N. A. Palmer, Paolo Brambilla, Ann-Christine Syvänen, Alun Evans, Åsa Johansson, John F. Peden, Alex S. F. Doney, Hugh Watkins, Johanna Kuusisto, Anders Lundmark, David G. Cox, Hyun Min Kang, Lars Lind, Krista Fischer, Markku S. Nieminen, Annette Peters, Norman Klopp, Stefan Gustafsson, Lars Wallentin, Nancy L. Pedersen, David-Alexandre Trégouët, Ulf de Faire
Publikováno v:
Nature Genetics
Nature Genetics; Vol 45
Nature genetics, 45(1), 25-33. Nature Publishing Group
Deloukas, P, Kanoni, S, Willenborg, C, Farrall, M, Assimes, T L, Thompson, J R, Ingelsson, E, Saleheen, D, Erdmann, J, Goldstein, B A, Stirrups, K, König, I R, Cazier, J B, Johansson, Å, Hall, A S, Lee, J Y, Willer, C J, Chambers, J C, Esko, T, Folkersen, L, Goel, A, Grundberg, E, Havulinna, A S, Ho, W K, Hopewell, J C, Eriksson, N, Kleber, M E, Kristiansson, K, Lundmark, P, Lyytikäinen, L P, Rafelt, S, Shungin, D, Strawbridge, R J, Thorleifsson, G, Tikkanen, E, Van Zuydam, N, Voight, B F, Waite, L L, Zhang, W, Ziegler, A, Absher, D, Altshuler, D, Balmforth, A J, Barroso, I, Braund, P S, Burgdorf, C, Claudi-Boehm, S, Cox, D, Dimitriou, M, Do, R, Doney, A S F, El Mokhtari, N, Eriksson, P, Fischer, K, Fontanillas, P, Franco-Cereceda, A, Gigante, B, Groop, L, Gustafsson, S, Hager, J, Hallmans, G, Han, B G, Hunt, S E, Kang, H M, Illig, T, Kessler, T, Knowles, J W, Kolovou, G, Kuusisto, J, Langenberg, C, Langford, C, Leander, K, Lokki, M L, Lundmark, A, McCarthy, M I, Meisinger, C, Melander, O, Mihailov, E, Maouche, S, Morris, A D, Müller-Nurasyid, M, Nikus, K, Peden, J F, Rayner, N W, Rasheed, A, Rosinger, S, Rubin, D, Rumpf, M P, Schäfer, A, Sivananthan, M, Song, C, Stewart, A F R, Tan, S T, Thorgeirsson, G, Van Der Schoot, C E, Wagner, P J, Wells, G A, Wild, P S, Yang, T P, Amouyel, P, Arveiler, D, Basart, H, Boehnke, M, Boerwinkle, E, Brambilla, P, Cambien, F, Cupples, A L, De Faire, U, Dehghan, A, Diemert, P, Epstein, S E, Evans, A, Ferrario, M M, Ferrières, J, Gauguier, D, Go, A S, Goodall, A H, Gudnason, V, Hazen, S L, Holm, H, Iribarren, C, Jang, Y, Kähönen, M, Kee, F, Kim, H S, Klopp, N, Koenig, W, Kratzer, W, Kuulasmaa, K, Laakso, M, Laaksonen, R, Lee, J Y, Lind, L, Ouwehand, W H, Parish, S, Park, J E, Pedersen, N L, Peters, A, Quertermous, T, Rader, D J, Salomaa, V, Schadt, E, Shah, S H, Sinisalo, J, Stark, K, Stefansson, K, Trégouët, D A, Virtamo, J, Wallentin, L, Wareham, N, Zimmermann, M E, Nieminen, M S, Hengstenberg, C, Sandhu, M S, Pastinen, T, Syvänen, A C, Hovingh, G K, Dedoussis, G, Franks, P W, Lehtimäki, T, Metspalu, A, Zalloua, P A, Siegbahn, A, Schreiber, S, Ripatti, S, Blankenberg, S S, Perola, M, Clarke, R, Boehm, B O, O'Donnell, C, Reilly, M P, März, W, Collins, R, Kathiresan, S, Hamsten, A, Kooner, J S, Thorsteinsdottir, U, Danesh, J, Palmer, C N A, Roberts, R, Watkins, H, Schunkert, H & Samani, N J 2013, ' Large-scale association analysis identifies new risk loci for coronary artery disease ', Nature Genetics, vol. 45, no. 1, pp. 25-33 . https://doi.org/10.1038/ng.2480
Nature Genetics; Vol 45
Nature genetics, 45(1), 25-33. Nature Publishing Group
Deloukas, P, Kanoni, S, Willenborg, C, Farrall, M, Assimes, T L, Thompson, J R, Ingelsson, E, Saleheen, D, Erdmann, J, Goldstein, B A, Stirrups, K, König, I R, Cazier, J B, Johansson, Å, Hall, A S, Lee, J Y, Willer, C J, Chambers, J C, Esko, T, Folkersen, L, Goel, A, Grundberg, E, Havulinna, A S, Ho, W K, Hopewell, J C, Eriksson, N, Kleber, M E, Kristiansson, K, Lundmark, P, Lyytikäinen, L P, Rafelt, S, Shungin, D, Strawbridge, R J, Thorleifsson, G, Tikkanen, E, Van Zuydam, N, Voight, B F, Waite, L L, Zhang, W, Ziegler, A, Absher, D, Altshuler, D, Balmforth, A J, Barroso, I, Braund, P S, Burgdorf, C, Claudi-Boehm, S, Cox, D, Dimitriou, M, Do, R, Doney, A S F, El Mokhtari, N, Eriksson, P, Fischer, K, Fontanillas, P, Franco-Cereceda, A, Gigante, B, Groop, L, Gustafsson, S, Hager, J, Hallmans, G, Han, B G, Hunt, S E, Kang, H M, Illig, T, Kessler, T, Knowles, J W, Kolovou, G, Kuusisto, J, Langenberg, C, Langford, C, Leander, K, Lokki, M L, Lundmark, A, McCarthy, M I, Meisinger, C, Melander, O, Mihailov, E, Maouche, S, Morris, A D, Müller-Nurasyid, M, Nikus, K, Peden, J F, Rayner, N W, Rasheed, A, Rosinger, S, Rubin, D, Rumpf, M P, Schäfer, A, Sivananthan, M, Song, C, Stewart, A F R, Tan, S T, Thorgeirsson, G, Van Der Schoot, C E, Wagner, P J, Wells, G A, Wild, P S, Yang, T P, Amouyel, P, Arveiler, D, Basart, H, Boehnke, M, Boerwinkle, E, Brambilla, P, Cambien, F, Cupples, A L, De Faire, U, Dehghan, A, Diemert, P, Epstein, S E, Evans, A, Ferrario, M M, Ferrières, J, Gauguier, D, Go, A S, Goodall, A H, Gudnason, V, Hazen, S L, Holm, H, Iribarren, C, Jang, Y, Kähönen, M, Kee, F, Kim, H S, Klopp, N, Koenig, W, Kratzer, W, Kuulasmaa, K, Laakso, M, Laaksonen, R, Lee, J Y, Lind, L, Ouwehand, W H, Parish, S, Park, J E, Pedersen, N L, Peters, A, Quertermous, T, Rader, D J, Salomaa, V, Schadt, E, Shah, S H, Sinisalo, J, Stark, K, Stefansson, K, Trégouët, D A, Virtamo, J, Wallentin, L, Wareham, N, Zimmermann, M E, Nieminen, M S, Hengstenberg, C, Sandhu, M S, Pastinen, T, Syvänen, A C, Hovingh, G K, Dedoussis, G, Franks, P W, Lehtimäki, T, Metspalu, A, Zalloua, P A, Siegbahn, A, Schreiber, S, Ripatti, S, Blankenberg, S S, Perola, M, Clarke, R, Boehm, B O, O'Donnell, C, Reilly, M P, März, W, Collins, R, Kathiresan, S, Hamsten, A, Kooner, J S, Thorsteinsdottir, U, Danesh, J, Palmer, C N A, Roberts, R, Watkins, H, Schunkert, H & Samani, N J 2013, ' Large-scale association analysis identifies new risk loci for coronary artery disease ', Nature Genetics, vol. 45, no. 1, pp. 25-33 . https://doi.org/10.1038/ng.2480
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to
Autor:
Jens Baumert, Gerjan Navis, Shelly G. Smith, Peter J. Grant, Anders Hamsten, Frances M K Williams, Russell P. Tracy, James B. Meigs, Maria Grazia Franzosi, Angela M. Carter, François Cambien, Wiek H. van Gilst, Kent D. Taylor, Folkert W. Asselbergs, Marcus E. Kleber, Kurt Lohman, Scott M. Williams, Saonli Basu, Martina Müller-Nurasyid, Angela Silveira, Pim van der Harst, Rory Collins, Geoffrey H. Tofler, Lasse Folkersen, Wolfgang Koenig, Christa Meisinger, Christopher J. O'Donnell, Qiong Yang, Aaron R. Folsom, John C. Chambers, Muredach P. Reilly, Norman Klopp, Weihong Tang, Ming-Huei Chen, Mahir Karakas, Bernhard R. Winkelmann, John Danesh, Sekar Kathiresan, Tamara B. Harris, Tim D. Spector, Pierre-Emmanuel Morange, John F. Peden, Danish Saleheen, Jaspal S. Kooner, Ann-Christine Syvänen, David-Alexandre Trégouët, Winfried März, Bernhard O. Boehm, Robert Clarke, Tiphaine Oudot-Mellakh, Nicholas L. Smith, Vinh Truong, Mary Cushman, André G. Uitterlinden, Lewis C. Becker, Joshua C. Bis, Udo Seedorf, Bengt Sennblad, Anders Franco-Cereceda, Yongmei Liu, Elisabeth M. C. Schrijvers, Hugh Watkins, Barbara McKnight, Diane M. Becker, Jingzhong Ding, Nicole Soranzo, Bruce M. Psaty, Anuj Goel, Per Eriksson, Mohammad Arfan Ikram, Annette Peters, So-Youn Shin, Abbas Dehghan, Lisa R. Yanek, Albert Hofman, Jason H. Moore, Hans L. Hillege, Per Lundmark, Jie Huang, Günther Silbernagel, Jemma C. Hopewell, John Öhrvik, Nena Matijevic, Alison H. Goodall, Maria Sabater-Lleal, Josyf C. Mychaleckyj, Rona J. Strawbridge, Andrew D. Johnson
Publikováno v:
Blood
Blood, 120(24), 4873-4881. American Society of Hematology
Blood, 120(24), 4873-4881. AMER SOC HEMATOLOGY
Blood; Vol 120
Blood, 120(24), 4873-4881. American Society of Hematology
Blood, 120(24), 4873-4881. AMER SOC HEMATOLOGY
Blood; Vol 120
We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discove
Autor:
Björn Zethelius, Agneta Siegbahn, Per Lundmark, Ann-Christine Syvänen, Marju Orho-Melander, Matti Jauhiainen, Olle Melander, Kristina Larsson, Riikka-Liisa Uronen, Elina Ikonen, Lars Wallentin
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology; Vol 30
Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology
Objective— To study how Niemann-Pick disease type C1 (NPC1) influences hepatic triacylglycerol (TG) metabolism and to determine whether this is reflected in circulating lipid levels. Methods and Results— In Npc1 −/− mice, the hepatic choleste
Autor:
Ingrid Agartz, Peter Saetre, Håkan Hall, Thomas Werge, Per Lundmark, Ingrid Melle, Srdjan Djurovic, Henrik B. Rasmussen, Erik G. Jönsson, August G. Wang, Lars Terenius, Thomas Hansen, Ole A. Andreassen
Publikováno v:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :387-396
Serotonin (5-hydroxytryptamin; 5-HT) alternations has since long been suspected in the pathophysiology of schizophrenia. Tryptophan hydroxylase (tryptophan 5-monooxygenase; TPH) is the rate-limiting enzyme in the biosynthesis of 5-HT, and sequence va
Autor:
Per Lundmark
Publikováno v:
IFAC Proceedings Volumes. 42:336-341
Within the global process industry, five percent of annual production is lost every year due to unscheduled downtime and poor quality. The ARC Advisory Group estimates that almost 80 percent of these losses are preventable and that 40 percent are pri
Autor:
Nicholas G. Martin, Heikki Mannila, Leena Peltonen, Tim D. Spector, Ulrika Liljedahl, Dorret I. Boomsma, Aarno Palotie, Ann-Christine Syvänen, Markus Perola, Per Lundmark
Publikováno v:
European Journal of Human Genetics, 16(9), 1142-1150. Nature Publishing Group
Lundmark, P E, Liljedahl, U, Boomsma, D I, Mannila, H, Martin, N G, Palotie, A, Peltonen, L, Perola, M, Spector, T D & Syvänen, A C 2008, ' Evaluation of HapMap data in six populations of European descent. ', European Journal of Human Genetics, vol. 16, no. 9, pp. 1142-1150 . https://doi.org/10.1038/ejhg.2008.77
Lundmark, P E, Liljedahl, U, Boomsma, D I, Mannila, H, Martin, N G, Palotie, A, Peltonen, L, Perola, M, Spector, T D & Syvänen, A C 2008, ' Evaluation of HapMap data in six populations of European descent. ', European Journal of Human Genetics, vol. 16, no. 9, pp. 1142-1150 . https://doi.org/10.1038/ejhg.2008.77
We studied how well the European CEU samples used in the Haplotype Mapping Project (HapMap) represent five European populations by analyzing nuclear family samples from the Swedish, Finnish, Dutch, British and Australian (European ancestry) populatio