Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Per Johan Klasse"'
Autor:
Philip J. M. Brouwer, Aleksandar Antanasijevic, Marlon de Gast, Joel D. Allen, Tom P. L. Bijl, Anila Yasmeen, Rashmi Ravichandran, Judith A. Burger, Gabriel Ozorowski, Jonathan L. Torres, Celia LaBranche, David C. Montefiori, Rajesh P. Ringe, Marit J. van Gils, John P. Moore, Per Johan Klasse, Max Crispin, Neil P. King, Andrew B. Ward, Rogier W. Sanders
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract The HIV-1 envelope glycoprotein trimer is poorly immunogenic because it is covered by a dense glycan shield. As a result, recombinant Env glycoproteins generally elicit inadequate antibody levels that neutralize clinically relevant, neutrali
Externí odkaz:
https://doaj.org/article/6d2ce266cff0455eb80fcc32049d700d
Autor:
Philip J. M. Brouwer, Aleksandar Antanasijevic, Zachary Berndsen, Anila Yasmeen, Brooke Fiala, Tom P. L. Bijl, Ilja Bontjer, Jacob B. Bale, William Sheffler, Joel D. Allen, Anna Schorcht, Judith A. Burger, Miguel Camacho, Daniel Ellis, Christopher A. Cottrell, Anna-Janina Behrens, Marco Catalano, Iván del Moral-Sánchez, Thomas J. Ketas, Celia LaBranche, Marit J. van Gils, Kwinten Sliepen, Lance J. Stewart, Max Crispin, David C. Montefiori, David Baker, John P. Moore, Per Johan Klasse, Andrew B. Ward, Neil P. King, Rogier W. Sanders
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nanoparticles are a promising approach to increase immunogenicity of protein antigens for vaccines. Here, Brouwer et al. design self-assembling, two-component protein NPs that present native-like SOSIP trimers of HIV envelope protein and determine im
Externí odkaz:
https://doaj.org/article/3f361bf123134e9fb806b778a2f53c71
Autor:
Aleksandar Antanasijevic, George Ueda, Philip J M Brouwer, Jeffrey Copps, Deli Huang, Joel D Allen, Christopher A Cottrell, Anila Yasmeen, Leigh M Sewall, Ilja Bontjer, Thomas J Ketas, Hannah L Turner, Zachary T Berndsen, David C Montefiori, Per Johan Klasse, Max Crispin, David Nemazee, John P Moore, Rogier W Sanders, Neil P King, David Baker, Andrew B Ward
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008665 (2020)
Two-component, self-assembling nanoparticles represent a versatile platform for multivalent presentation of viral antigens. Computational design of protein nanoparticles with differing sizes and geometries enables combination with antigens of choice
Externí odkaz:
https://doaj.org/article/bef6f6ca42a24283ba89afa6be5d0385
Autor:
George Ueda, Aleksandar Antanasijevic, Jorge A Fallas, William Sheffler, Jeffrey Copps, Daniel Ellis, Geoffrey B Hutchinson, Adam Moyer, Anila Yasmeen, Yaroslav Tsybovsky, Young-Jun Park, Matthew J Bick, Banumathi Sankaran, Rebecca A Gillespie, Philip JM Brouwer, Peter H Zwart, David Veesler, Masaru Kanekiyo, Barney S Graham, Rogier W Sanders, John P Moore, Per Johan Klasse, Andrew B Ward, Neil P King, David Baker
Publikováno v:
eLife, Vol 9 (2020)
Multivalent presentation of viral glycoproteins can substantially increase the elicitation of antigen-specific antibodies. To enable a new generation of anti-viral vaccines, we designed self-assembling protein nanoparticles with geometries tailored t
Externí odkaz:
https://doaj.org/article/1cb71cd9d73d4231af8ba7577a9734db
Autor:
Alba Torrents de la Peña, Jean-Philippe Julien, Steven W. de Taeye, Fernando Garces, Miklos Guttman, Gabriel Ozorowski, Laura K. Pritchard, Anna-Janina Behrens, Eden P. Go, Judith A. Burger, Edith E. Schermer, Kwinten Sliepen, Thomas J. Ketas, Pavel Pugach, Anila Yasmeen, Christopher A. Cottrell, Jonathan L. Torres, Charlotte D. Vavourakis, Marit J. van Gils, Celia LaBranche, David C. Montefiori, Heather Desaire, Max Crispin, Per Johan Klasse, Kelly K. Lee, John P. Moore, Andrew B. Ward, Ian A. Wilson, Rogier W. Sanders
Publikováno v:
Cell Reports, Vol 20, Iss 8, Pp 1805-1817 (2017)
The production of native-like recombinant versions of the HIV-1 envelope glycoprotein (Env) trimer requires overcoming the natural flexibility and instability of the complex. The engineered BG505 SOSIP.664 trimer mimics the structure and antigenicity
Externí odkaz:
https://doaj.org/article/e7d96db6274240d3b42a1f6452b63128
Autor:
Katie Matthews, Nancy P Y Chung, Per Johan Klasse, Magda Moutaftsi, Darrick Carter, André M Salazar, Steven G Reed, Rogier W Sanders, John P Moore
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63785 (2013)
CD14(+) dermal DCs (CD14(+) DDCs) have a natural capacity to activate naïve B-cells. Targeting CD14(+) DDCs is therefore a rational approach for vaccination strategies aimed at improving humoral responses towards poorly immunogenic antigens, for exa
Externí odkaz:
https://doaj.org/article/ffbf75467d35465683639068d5015de6
Autor:
Meimei Shan, Per Johan Klasse, Kaustuv Banerjee, Antu K Dey, Sai Prasad N Iyer, Robert Dionisio, Dustin Charles, Lila Campbell-Gardener, William C Olson, Rogier W Sanders, John P Moore
Publikováno v:
PLoS Pathogens, Vol 3, Iss 11, p e169 (2007)
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 is a vaccine immunogen that can signal via several cell surface receptors. To investigate whether receptor biology could influence immune responses to gp120, we studied its i
Externí odkaz:
https://doaj.org/article/c4960ccf37e145a796aa35e5d170473a
Publikováno v:
PLoS Medicine, Vol 3, Iss 9, p e351 (2006)
Externí odkaz:
https://doaj.org/article/be9f71432848414782cd440c06c6f1ca
Autor:
Kalpana Gupta, Per Johan Klasse
Publikováno v:
PLoS Medicine, Vol 3, Iss 2, p e79 (2006)
Externí odkaz:
https://doaj.org/article/130c48e23a55464e8dcb8268fc1323d5
Autor:
Tom G. Caniels, Max Medina-Ramírez, Jinsong Zhang, Anita Sarkar, Sonu Kumar, Alex LaBranche, Ronald Derking, Joel D. Allen, Jonne L. Snitselaar, Joan Capella-Pujol, Iván del Moral Sánchez, Anila Yasmeen, Marilyn Diaz, Yoann Aldon, Tom P.L. Bijl, Sravani Venkatayogi, Joshua S. Martin Beem, Amanda Newman, Chuancang Jiang, Wen-Hsin Lee, Maarten Pater, Judith A. Burger, Mariëlle J. van Breemen, Steven W. de Taeye, Kimmo Rantalainen, Celia LaBranche, Kevin O. Saunders, David Montefiori, Gabriel Ozorowski, Andrew B. Ward, Max Crispin, John P. Moore, Per Johan Klasse, Barton F. Haynes, Ian A. Wilson, Kevin Wiehe, Laurent Verkoczy, Rogier W. Sanders
Publikováno v:
Cell Reports Medicine, 4(4):101003. Cell Press
Targeting germline (gl-) precursors of broadly neutralizing antibodies (bNAbs) is acknowledged as an important strategy for HIV-1 vaccines. The VRC01-class of bNAbs is attractive because of its distinct genetic signature. However, VRC01-class bNAbs o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0abe01ee8ed5d55e0d1a359126af9aa
https://pure.amc.nl/en/publications/germlinetargeting-hiv1-env-vaccination-induces-vrc01class-antibodies-with-rare-insertions(4a3cf33f-bbcf-4f4c-ad44-92262e9dbc5d).html
https://pure.amc.nl/en/publications/germlinetargeting-hiv1-env-vaccination-induces-vrc01class-antibodies-with-rare-insertions(4a3cf33f-bbcf-4f4c-ad44-92262e9dbc5d).html