Výsledky vyhledávání - "Per Ingvar Ohlsson"

Normal Binding and Reactivity of Copper in Mutant Superoxide Dismutase Isolated from Amyotrophic Lateral Sclerosis Patients

Autor: Göran Wikander, Peter Nilsson, Per-Ingvar Ohlsson, Lars Forsgren, Agneta Öberg, Peter M. Andersen, Stefan L. Marklund

Publikováno v: Journal of Neurochemistry. 69:675-681

In some families with amyotrophic lateral sclerosis (ALS), the disease is linked to mutations in the gene encoding CuZn-superoxide dismutase. The mutant CuZn-superoxide dismutases appear to cause motor neuron degeneration by a toxic property, suggest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b28e193060ecec7f45a1ef090f29ff
https://doi.org/10.1046/j.1471-4159.1997.69020675.x

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A new diagnostic procedure to detect unknown transthyretin (TTR) mutations in familial amyloidotic polyneuropathy (FAP)

Autor: Ole B. Suhr, Masayuki Ando, Per Ingvar Ohlsson, Makoto Uchino, Yukio Ando, Hisayasu Terazaki, Naomi Sakashita, Konen Obayashi, Masaaki Nakamura, Taro Yamashita

Publikováno v: Journal of the Neurological Sciences. 173:154-159

Two patients with amyloidosis caused by transthyretin (TTR) were investigated by immunohistopathologic, mass spectrometric, and molecular genetic methods. After confirming the immunoreactivity of TTR in the amyloid deposits using anti-TTR polyclonal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bf6cca9134d09d1991d981f83ee707
https://doi.org/10.1016/s0022-510x(99)00326-3

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Analysis of transthyretin amyloid fibrils from vitreous samples in familial amyloidotic polyneuropathy (Val Met)

Autor: Ola Sandgren, Konen Obayashi, Hisayasu Terazaki, Per Ingvar Ohlsson, Akira Negi, Yukio Ando, Erik Lundgren, Anders Olofsson, Eiko Ando, Ole B. Suhr, Masayuki Ando

Publikováno v: Amyloid. 6:119-123

The aim of the present study was to analyze the forms of wild type and mutated monomeric transthyretin (Val3 et) in the amyloid fibrils of patients with familial amyloidotic polyneuropathy by electrospray ionization mass spectrometry (ESI-MS).The sol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::420c3377cf08987da8e1f97048ac4cb4
https://doi.org/10.3109/13506129909007312

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Post-translational Modification of Transthyretin in Plasma

Autor: Per Ingvar Ohlsson, Masayuki Ando, Ole B. Suhr, Makoto Uchino, Yukio Ando, Shin Ichi Yoshimatsu, Konen Obayashi, Hisayasu Terazaki, Moritaka Suga, Taro Yamashita

Publikováno v: Biochemical and Biophysical Research Communications. 249:26-30

To determine the behavior of transthyretin (TTR) in blood circulation, TTR purified from normal subjects’ plasma was injected to rats, and blood and urine were collected time dependently. Although TTR in plasma was proven to be a predominantly cyst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e866de1be7a0d1b7c76875b899665ee
https://doi.org/10.1006/bbrc.1998.9097

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A New Simple and Rapid Screening Method for Variant Transthyretin-Related Amyloidosis

Autor: Ole B. Suhr, Per Ingvar Ohlsson, Masayuki Ando, Makoto Uchino, Yukio Ando, Ola Sandgren, Gösta Holmgren, Taro Yamashita, Nils Nyhlin, Åke Danielsson

Publikováno v: Biochemical and Biophysical Research Communications. 228:480-483

To screen for transthyretin (TTR) related amyloidosis rapidly and reliably, we have developed a new method using a centrifugal concentrator device and electrospray ionization mass spectrometry (ESI-MS). Only 50 μl of serum is needed for the analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2d8692a7ff6fa971dd380843555b63
https://doi.org/10.1006/bbrc.1996.1685

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Impact of age and amyloidosis on thiol conjugation of transthyretin in hereditary transthyretin amyloidosis

Autor: Per Ingvar Ohlsson, Ole B. Suhr, Yukio Ando, Poul Jorgen Ranlov, J. Lendoire, Kazuhiro Tashima, Pedro Trigo, Ida Hastrup Svendsen

Publikováno v: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 6(3)

Variant forms and post-translational modifications of transthyretin (TTR) can be identified by electrospray ionisation mass spectrometry (ESI-MS). The aim of the present study was to investigate thiol conjugation of transthyretin and it's relation to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25728f2bab8257bdfbb8b10272ebf8cc
https://pubmed.ncbi.nlm.nih.gov/10524283

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Identification of a new transthyretin variant (Ile49) in familial amyloidotic polyneuropathy using electrospray ionization mass spectrometry and nonisotopic RNase cleavage assay

Autor: Per Ingvar Ohlsson, Kamran Hamidi Asl, Taro Yamashita, Yukio Kususe, Yukio Ando, Masaaki Nakamura, Kazuhiro Tashima, Merrill D. Benson

Publikováno v: Human heredity. 49(4)

Mutation of the transthyretin (TTR) plasma protein and gene in a Japanese patient with amyloid polyneuropathy was investigated by electrospray ionization mass spectrometry (ESI-MS) and nonisotopic RNase cleavage assay (NIRCA), respectively. ESI-MS an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7687056fcafc64026a91df3d1e2d34d0
https://pubmed.ncbi.nlm.nih.gov/10436378

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Unusual self-association properties of transthyretin Y114C related to familial amyloidotic polyneuropathy: effects on detection and quantification

Autor: Akira Negi, Per Ingvar Ohlsson, Yukio Ando, Hisayasu Terazaki, Maria Rosário Almeida, Konen Obayashi, Maria João Saraiva, Ole B. Suhr, Masayuki Ando, Eiko Ando

Publikováno v: Biochemical and biophysical research communications. 261(2)

We performed biochemical and immunological examinations of heterozygotic carriers of the transthyretin (TTR) mutant Y114C associated with familial amyloidotic polyneuropathy (FAP). The total serum TTR levels in Y114C TTR carriers were extremely low w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d170618f3501c30e17ecf137d9b3fa48
https://pubmed.ncbi.nlm.nih.gov/10425176

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Proteolytic modification of tissue plasminogen activator: importance of the N-terminal part of the catalytically active B-chain for enzymic activity

Autor: Per Ingvar Ohlsson, Bosse Norrman, Per Wallén

Publikováno v: Biochemistry. 27:8325-8330

Native one-chain tissue plasminogen activator (t-PA) was rapidly converted to the two-chain form by trypsin-Sepharose cleavage. This caused an increase in the amidolytic activity on low molecular weight peptide substrates, while plasminogen activatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722ae3b40d6e307eb6bcef45a95cb070
https://doi.org/10.1021/bi00422a006

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Infrared spectroscopic studies of carbonyl horseradish peroxidases

Autor: K. G. Paul, Clyde H. Barlow, Per Ingvar Ohlsson

Publikováno v: Biochemistry. 15:2225-2229

Infrared difference spectra, FeIIICO vs. FeIII of horseradish peroxidase isoenzymes A2 and C were recorded from 2000 to 1800 cm-1. Under alkaline conditions, pH 9, both isoenzymes exhibit two CO stretching bands, at 1938 and 1925 cm-1 for A2 and at 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b70c327902a366194c7c4f6efcafaa
https://doi.org/10.1021/bi00655a031

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