Short-term spheroid culture of primary colorectal cancer cells as an in vitro model for personalizing cancer medicine.

Autor: Maria Jeppesen, Grith Hagel, Anders Glenthoj, Ben Vainer, Per Ibsen, Henrik Harling, Ole Thastrup, Lars N Jørgensen, Jacob Thastrup

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0183074 (2017)

Chemotherapy treatment of cancer remains a challenge due to the molecular and functional heterogeneity displayed by tumours originating from the same cell type. The pronounced heterogeneity makes it difficult for oncologists to devise an effective th

Externí odkaz: https://doaj.org/article/9df1d329274e465686b17eb5dcc4db76

Genomic alterations accompanying tumour evolution in colorectal cancer: tracking the differences between primary tumours and synchronous liver metastases by whole-exome sequencing

Autor: M. B. Mogensen, Jens Ravn Eriksen, Morten Grauslund, Per Ibsen, Olga Østrup, Finn Cilius Nielsen, P. J. Heiberg Engel, Estrid Høgdall, Maria Rossing, Hans Jørgen Nielsen, Per Jess, Kell Østerlind, Ben Vainer, Lars N. Jorgensen, P. N. Larsen

Publikováno v: BMC Cancer
Mogensen, M B, Rossing, M, Østrup, O, Larsen, P N, Heiberg Engel, P J, Jørgensen, L N, Hogdall, E V, Eriksen, J, Ibsen, P, Jess, P, Grauslund, M, Nielsen, H J, Nielsen, F C, Vainer, B & Osterlind, K 2018, ' Genomic alterations accompanying tumour evolution in colorectal cancer : tracking the differences between primary tumours and synchronous liver metastases by whole-exome sequencing ', BMC Cancer, vol. 18, 752 . https://doi.org/10.1186/s12885-018-4639-4
BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018)

Background Colorectal cancer (CRC) patients with metastatic disease can become cured if neoadjuvant treatment can enable a resection. The search for predictive biomarkers is often performed on primary tumours tissue. In order to assess the effectiven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1d55dbd7608cd53d2a53a52b970a2d
https://doi.org/10.1186/s12885-018-4639-4

Detection of electroporation-induced membrane permeabilization states in the brain using diffusion-weighted MRI

Autor: Hanne Gissel, Julie Gehl, Per Ibsen, Birgit Agerholm-Larsen, Faisal Mahmood, Rasmus Hvass Hansen

Publikováno v: Acta Oncologica (Stockholm, Sweden)

Background Tissue permeabilization by electroporation (EP) is a promising technique to treat certain cancers. Non-invasive methods for verification of induced permeabilization are important, especially in deep-seated cancers. In this study we evaluat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b4e478935a00fec442cb13bf277ae4
https://doi.org/10.3109/0284186x.2014.991045

Preclinical Validation of Electrochemotherapy as an Effective Treatment for Brain Tumors

Autor: Julie Gehl, Faisal Mahmood, Helle K. Iversen, Jakob M Møller, Kurt Svarre Jensen, Birgit Agerholm-Larsen, Per Ibsen

Publikováno v: Cancer Research. 71:3753-3762

Electrochemotherapy represents a strategy to enhance chemotherapeutic drug uptake by delivering electrical pulses which exceed the dielectric strength of the cell membrane, causing transient formation of structures that enhance permeabilization. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4edc55a645f16268cc07380b34f15f
https://doi.org/10.1158/0008-5472.can-11-0451

Short-term spheroid culture of primary colorectal cancer cells as an in vitro model for personalizing cancer medicine

Autor: Per Ibsen, Ben Vainer, Maria Jeppesen, Jacob Thastrup, Ole Thastrup, Anders Glenthøj, Lars N. Jorgensen, Grith Hagel, Henrik Harling

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0183074 (2017)
Jeppesen, M, Hagel, G, Glenthoj, A, Vainer, B, Ibsen, P, Harling, H, Thastrup, O, Jørgensen, L N & Thastrup, J 2017, ' Short-term spheroid culture of primary colorectal cancer cells as an in vitro model for personalizing cancer medicine ', PLOS ONE, vol. 12, no. 9, e0183074 . https://doi.org/10.1371/journal.pone.0183074
PLoS ONE

Chemotherapy treatment of cancer remains a challenge due to the molecular and functional heterogeneity displayed by tumours originating from the same cell type. The pronounced heterogeneity makes it difficult for oncologists to devise an effective th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ab0ee21037033b864d37d17a436be9
https://doi.org/10.1371/journal.pone.0183074