Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Per Holmfeldt"'
Autor:
Shannon McKinney-Freeman, Megan Walker, Marie Bordas, Lance E. Palmer, Miguel Ganuza, Per Holmfeldt, Trent Hall, Guolian Kang, Wenjian Bi, David Finkelstein
Publikováno v:
Stem Cells. 36:943-950
Hematopoietic stem and progenitor cells (HSPCs) are necessary for life-long blood production and replenishment of the hematopoietic system during stress. We recently reported that nuclear factor I/X (Nfix) promotes HSPC survival post-transplant. Here
Autor:
Bing He, Alba Cico, Shannon McKinney-Freeman, Daniel J. McGoldrick, Angelica C. Saulsberry, David Finkelstein, Miguel Ganuza, Kai Tan, Joseph Moen, Trent Hall, Per Holmfeldt, Jennifer Pardieck, Ludovic Gaut, Himangi Marathe, Guolian Kang
Publikováno v:
Journal of Experimental Medicine. 213:433-449
Understanding the molecular regulation of hematopoietic stem and progenitor cell (HSPC) engraftment is paramount to improving transplant outcomes. To discover novel regulators of HSPC repopulation, we transplanted >1,300 mice with shRNA-transduced HS
Publikováno v:
Molecular Biology of the Cell
Septin assemblies during the interphase of animal cells remain poorly defined and are the topic of this report. The data point to a general model for assembly of higher-order septin arrangements at locations providing the greatest opportunity for bin
Publikováno v:
Cellular and Molecular Life Sciences. 66:3263-3276
The microtubule-system organizes the cytoplasm during interphase and segregates condensed chromosomes during mitosis. Four unrelated conserved proteins, XMAP215/Dis1/TOGp, MCAK, MAP4 and Op18/stathmin, have all been implicated as predominant regulato
Publikováno v:
Molecular Biology of the Cell. 19:2897-2906
Op18/stathmin (Op18), a conserved microtubule-depolymerizing and tubulin heterodimer-binding protein, is a major interphase regulator of tubulin monomer–polymer partitioning in diverse cell types in which Op18 is abundant. Here, we addressed the qu
Autor:
Victoria Shingler, Eleonore Skärfstad, Rebecca E. Parales, Sofie Holmqvist, Sofia Österberg, Inga Sarand, Per Holmfeldt
Publikováno v:
Environmental Microbiology. 10:1320-1334
Comparatively little is known about directed motility of environmental bacteria to common aromatic pollutants. Here, by expressing different parts of a (methyl)phenol-degradative pathway and the use of specific mutants, we show that taxis of Pseudomo
Publikováno v:
Experimental Cell Research. 314:1367-1377
Op18/stathmin (Op18) is a phosphorylation-regulated and differentially expressed microtubule-destabilizing protein in animal cells. Op18 regulates tubulin monomer-polymer partitioning of the interphase microtubule system and forms complexes with tubu
Publikováno v:
The EMBO Journal. 24:1256-1266
MCAK, a member of the kinesin-13 family, is a microtubule (MT) depolymerase that is necessary to ensure proper kinetochore MT attachment during spindle formation. Regulation of MCAK activity and localization is controlled in part by Aurora B kinase a
Publikováno v:
The EMBO Journal. 23:627-637
XMAP215/TOGp family members and KinI kinesins are conserved microtubule (MT)-regulatory proteins, and have been viewed as possessing prominent antagonistic stabilizing/destabilizing activities that must be balanced. Here, interdependencies between TO
Publikováno v:
Journal of Cell Science. 116:197-205
Op18 is the prototypical member of a family of phosphorylation-responsive regulators of microtubule (MT) dynamics. Previous dissection of Op18 has suggested that it has a functional dichotomy in which an intact N-terminus is required for catastrophe