Lecocytes mutation load declines with age in carriers of the m.3243A>G mutation: A 10-year Prospective Cohort

Autor: Knud Bonnet Yderstræde, Mads Thomassen, Anja Lisbeth Frederiksen, Per Heden Andersen, Morten Duno, John Vissing, Jakob Høgild Langdahl, Martin Jakob Larsen, Morten Frost

Publikováno v: Langdahl, J H, Larsen, M, Frost, M, Andersen, P H, Yderstraede, K B, Vissing, J, Dunø, M, Thomassen, M & Frederiksen, A L 2018, ' Lecocytes mutation load declines with age in carriers of the m.3243A >G mutation : A 10-year Prospective Cohort ', Clinical Genetics, vol. 93, no. 4, pp. 925-928 . https://doi.org/10.1111/cge.13201

Carriers of the mitochondrial mutation m.3243A>G presents highly variable phenotypes including mitochondrial encephalomyopathy, lactoacidosis and stroke-like episodes (MELAS). We conducted a follow-up study to evaluate changes in leucocyte heteroplas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922f5232e0e3e5509448c10136fb462a
https://doi.org/10.1111/cge.13201

Mitochondrial mutation m.3243A>G associates with insulin resistance in non-diabetic carriers

Autor: Anja Lisbeth Frederiksen, Knud Bonnet Yderstræde, John Vissing, Jakob Høgild Langdahl, Per Heden Andersen, Morten Frost

Publikováno v: Langdahl, J H, Frederiksen, A L, Vissing, J, Frost, M, Yderstræde, K B & Andersen, P H 2019, ' Mitochondrial mutation m.3243A >G associates with insulin resistance in non-diabetic carriers. ', Endocrine Connections, vol. 8, no. 7, pp. 829–837 . https://doi.org/10.1530/EC-19-0118
Endocrine Connections
Langdahl, J H, Frederiksen, A L, Vissing, J, Frost, M, Yderstræde, K B & Andersen, P H 2019, ' Mitochondrial mutation m.3243A >G associates with insulin resistance in non-diabetic carriers ', Endocrine Connections, vol. 8, no. 7, pp. 829-837 . https://doi.org/10.1530/EC-19-0118
Endocrine Connections, Vol 8, Iss 7, Pp 829-837 (2019)

Aim This case–control study aimed to examine impairments in glucose metabolism in non-diabetic carriers of the mitochondrial mutation m.3243A>G by evaluating insulin secretion capacity and sensitivity. Methods Glucose metabolism was investigated in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f085afd825eade5ddbe87322553c5fe9
https://findresearcher.sdu.dk:8443/ws/files/151612210/_20493614_Endocrine_Connections_Mitochondrial_mutation_m.3243A_gt_G_associates_with_insulin_resistance_in_non_diabetic_carriers.pdf

Mitochondrial Point Mutation m.3243AG Associates With Lower Bone Mineral Density, Thinner Cortices, and Reduced Bone Strength: A Case-Control Study

Autor: Jakob Høgild, Langdahl, Anja Lisbeth, Frederiksen, Stinus Jørn, Hansen, Per Heden, Andersen, Knud Bonnet, Yderstraede, Morten, Dunø, John, Vissing, Morten, Frost

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 32(10)

Mitochondrial dysfunction is associated with several clinical manifestations including diabetes mellitus (DM), neurological disorders, renal and hepatic diseases, and myopathy. Although mitochondrial dysfunction is associated with increased bone reso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2ba4aeee677882187da8561c83643b17
https://pubmed.ncbi.nlm.nih.gov/28850729

High Prevalence of Impaired Glucose Homeostasis and Myopathy in Asymptomatic and Oligosymptomatic 3243A>G Mitochondrial DNA Mutation-Positive Subjects

Autor: Marianne Schwartz, Kirsten Ohm Kyvik, Anja Lisbeth Frederiksen, Ole Schmitz, John Vissing, Per Heden Andersen, Tina D. Jeppesen, Per Løgstrup Poulsen

Publikováno v: Frederiksen, A L, Jeppesen, T D, Vissing, J, Schwartz, M, Kyvik, K O, Schmitz, O, Poulsen, P L & Andersen, P H 2009, ' High prevalence of impaired glucose homeostasis and myopathy in asymptomatic and oligosymptomatic 3243A >G mitochondrial DNA mutation-positive subjects ', Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 8, pp. 2872-9 . https://doi.org/10.1210/jc.2009-0235

Udgivelsesdato: 2009-Aug INTRODUCTION: The point mutation of 3243A>G mtDNA is the most frequent cause of mitochondrial diabetes, often presenting as the syndrome maternally inherited diabetes and deafness (MIDD). The mutation may also cause myopathy,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f66f42f6b9b64c8fb43bf1b1f887493
https://doi.org/10.1210/jc.2009-0235

Effects of long-term total fasting and insulin on ob gene expression in obese patients

Autor: Kurt Kristensen, Ole Schmitz, Per Heden Andersen, Steen B. Pedersen, Hjøllund E, Bjørn Richelsen

Publikováno v: European Journal of Endocrinology. :229-233

In the present study the effect of long-term fasting (6 days) on obese (ob) gene expression was examined in nine severely obese females of 34 +/- 3 years and with a body mass index of 46.4 +/- 2.3 kg/m2. Six days of fasting induced a significant weig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9072df90ab7c67dd31b0ef073521a5b8
https://doi.org/10.1530/eje.0.1370229