Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Per E Lønning"'
Autor:
Andliena Tahiri, Kathrine Røe, Anne H Ree, Rik de Wijn, Karianne Risberg, Christian Busch, Per E Lønning, Vessela Kristensen, Jürgen Geisler
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72692 (2013)
Treatment of metastatic malignant melanoma patients harboring BRAF(V600E) has improved drastically after the discovery of the BRAF inhibitor, vemurafenib. However, drug resistance is a recurring problem, and prognoses are still very bad for patients
Externí odkaz:
https://doaj.org/article/01a0e258138b4d65a4716442b32d37e2
Autor:
Oleksii Nikolaienko, Hans P. Eikesdal, Elisabet Ognedal, Bjørnar Gilje, Steinar Lundgren, Egil S. Blix, Helge Espelid, Jürgen Geisler, Stephanie Geisler, Emiel A. M. Janssen, Synnøve Yndestad, Laura Minsaas, Beryl Leirvaag, Reidun Lillestøl, Stian Knappskog, Per E. Lønning
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background Normal cell BRCA1 epimutations have been associated with increased risk of triple-negative breast cancer (TNBC). However, the fraction of TNBCs that may have BRCA1 epimutations as their underlying cause is unknown. Neither are the
Externí odkaz:
https://doaj.org/article/0089602380aa46b390f13cb9bbdb281f
Autor:
Stian Knappskog, Liv B Gansmo, Pål Romundstad, Merete Bjørnslett, Jone Trovik, Jan Sommerfelt-Pettersen, Erik Løkkevik, Norwegian Breast Cancer Group trial NBCG VI, Rob A E M Tollenaar, Caroline Seynaeve, Peter Devilee, Helga B Salvesen, Anne Dørum, Kristian Hveem, Lars Vatten, Per E Lønning
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36263 (2012)
The MDM2 proto-oncogene plays a key role in central cellular processes like growth control and apoptosis, and the gene locus is frequently amplified in sarcomas. Two polymorphisms located in the MDM2 promoter P2 have been shown to affect cancer risk.
Externí odkaz:
https://doaj.org/article/73927cc6763348dd8815069ae625c8b3
Autor:
Cornelia Schuster, Hans P Eikesdal, Hanne Puntervoll, Jürgen Geisler, Stephanie Geisler, Daniel Heinrich, Anders Molven, Per E Lønning, Lars A Akslen, Oddbjørn Straume
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38364 (2012)
VEGF driven angiogenesis plays a key role in cancer progression. We determined the clinical efficacy of bevacizumab monotherapy in patients with metastatic melanoma.Thirty-five patients with metastatic melanoma in progression were enrolled in this ph
Externí odkaz:
https://doaj.org/article/a7707573dd0e460aa22a352803224f06
Autor:
Nigar Sofiyeva, Camilla Krakstad, Mari K. Halle, Tracy A. O'Mara, Pål Romundstad, Kristian Hveem, Lars Vatten, Per E. Lønning, Liv B. Gansmo, Stian Knappskog
Publikováno v:
Cancer Medicine, Vol 12, Iss 6, Pp 6659-6667 (2023)
Abstract Background A common 30 kb deletion affecting the APOBEC3A and APOBEC3B genes has been linked to increased APOBEC activity and APOBEC‐related mutational signatures in human cancers. The role of this deletion as a cancer risk factor remains
Externí odkaz:
https://doaj.org/article/4ceaeac0dc614338b1f48747cdc9b398
Autor:
Xiao-Zheng Liu, Anastasiia Rulina, Man Hung Choi, Line Pedersen, Johanna Lepland, Sina T. Takle, Noelly Madeleine, Stacey D’mello Peters, Cara Ellen Wogsland, Sturla Magnus Grøndal, James B. Lorens, Hani Goodarzi, Per E. Lønning, Stian Knappskog, Anders Molven, Nils Halberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Obesity is linked to cancer risk in post-menopausal breast cancer. At the molecular level this is governed by cellular adaption to palmitic acid through epigenetic activation of a C/EBPB-dependent transcriptional network that drives tumor formation.
Externí odkaz:
https://doaj.org/article/2bacdd7297484e79a552adc0048209b9
Autor:
Liv B. Gansmo, Nigar Sofiyeva, Merete Bjørnslett, Pål Romundstad, Kristian Hveem, Lars Vatten, Anne Dørum, Per E. Lønning, Stian Knappskog
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract A germline 29.5-kb deletion variant removes the 3’ end of the APOBEC3A gene and a large part of APOBEC3B, creating a hybrid gene that has been linked to increased APOBEC3 activity and DNA damage in human cancers. We genotyped the APOBEC3A/
Externí odkaz:
https://doaj.org/article/12a41c4868b348eebff763953c5fbf09
Autor:
Elin Borgen, Maria C. Rypdal, Maria Soledad Sosa, Anne Renolen, Ellen Schlichting, Per E. Lønning, Marit Synnestvedt, Julio A. Aguirre-Ghiso, Bjørn Naume
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-13 (2018)
Abstract Background The presence of disseminated tumor cells (DTCs) in bone marrow (BM) is an independent prognostic factor in early breast cancer but does not uniformly predict outcome. Tumor cells can persist in a quiescent state over time, but cli
Externí odkaz:
https://doaj.org/article/521c5332ad384ee18c83f33a4edd8b9a
Autor:
Nigar Sofiyeva, Camilla Krakstad, Mari K. Halle, Tracy A. O'Mara, Pål Romundstad, Kristian Hveem, Lars Vatten, Per E. Lønning, Liv B. Gansmo, Stian Knappskog
Publikováno v:
Cancer Medicine
Background A common 30 kb deletion affecting the APOBEC3A and APOBEC3B genes has been linked to increased APOBEC activity and APOBEC-related mutational signatures in human cancers. The role of this deletion as a cancer risk factor remains controversi
Autor:
Oleksii Nikolaienko, Hans P. Eikesdal, Bjørnar Gilje, Steinar Lundgren, Egil S. Blix, Helge Espelid, Jürgen Geisler, Stephanie Geisler, Emiel A.M. Janssen, Synnøve Yndestad, Laura Minsaas, Beryl Leirvaag, Reidun Lillestøl, Stian Knappskog, Per E. Lønning
BackgroundNormal cellBRCA1epimutations have been associated with increased risk of triple-negative breast cancer (TNBC). However, the fraction of TNBCs that may haveBRCA1epimutations as their underlying cause is unknown.MethodsTo address this questio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2190358b63fbbf66a48d7d6bfcc2496
https://doi.org/10.1101/2023.05.14.23289949
https://doi.org/10.1101/2023.05.14.23289949