An immunogenic first-in-human immune modulatory vaccine with PD-L1 and PD-L2 peptides is feasible and shows early signs of efficacy in follicular lymphoma

Autor: Marie Fredslund Breinholt, Stine Emilie Weis-Banke, Guy Wayne Novotny, Nicolai Grønne Jørgensen, Anne Ortved Gang, Inge Marie Svane, Mads Hald Andersen, Lars Møller Pedersen, Uffe Klausen, Özcan Met, Lone Bredo Pedersen, Morten Orebo Holmström, Shamaila Munir Ahmad, Per Boye Hansen, Jacob Handlos Grauslund, Carsten Utoft Niemann, Julie Westerlin Kjeldsen, Evelina Martinenaite, Christian Bjørn Poulsen

Publikováno v: Klausen, U, Grønne Dahlager Jørgensen, N, Grauslund, J H, Munir Ahmad, S, Gang, A O, Martinenaite, E, Weis-Banke, S E, Breinholt, M F, Novotny, G W, Kjeldsen, J W, Orebo Holmström, M, Pedersen, L B, Poulsen, C B, Hansen, P B, Met, Ö, Svane, I M, Niemann, C U, Pedersen, L M & Andersen, M H 2021, ' An immunogenic first-in-human immune modulatory vaccine with PD-L1 and PD-L2 peptides is feasible and shows early signs of efficacy in follicular lymphoma ', OncoImmunology, vol. 10, no. 1, 1975889 . https://doi.org/10.1080/2162402X.2021.1975889
OncoImmunology, Vol 10, Iss 1 (2021)

Cells in the tumor microenvironment of Follicular lymphoma (FL) express checkpoint molecules such as programmed death ligands 1 and 2 (PD-L1 and PD-L2) and are suppressing anti-tumor immune activity. Stimulation of peripheral blood mononuclear cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d38890a5dbc61173e18dfdd21811ed
https://doi.org/10.1080/2162402x.2021.1975889

Successful Treatment of Posttransplant EBV-Associated Lymphoma and Plasmacytoma Solely Localized to the CNS

Autor: Per Boye Hansen, Signe Ledou Nielsen

Publikováno v: Case Reports in Hematology, Vol 2012 (2012)

Two patients with diabetic nephropathy were diagnosed with primary central nervous system posttransplant Epstein-Barr-virus-associated lymphoproliferative disorder (PTLD) 3 years after renal transplantation. The histological diagnoses of the isolated

Externí odkaz: https://doaj.org/article/bf66456eb252456398d4fb76cfa2c902

Clinical Impact of Clonal Hematopoiesis after Autologous Stem Cell Transplantation for Lymphoma:A National Population-Based Cohort Study

Autor: Eva Kannik Hastrup, Simon Husby, Anne Fischer-Nielsen, Erik Segel, Michael Thorsgaard, Christian Nielsen, Bente Arboe, Kathrine Grell, Jakob Werner Hansen, Tarec Christoffer El-Galaly, Lene Hyldahl Ebbesen, Kirsten Grønbæk, German G. R. Gonzalez, Lisbeth Pernille Andersen, Lene Meldgaard Knudsen, Joachim Weisenfeldt, Favero Francesco, Ilse Christiansen, Per Boye Hansen, Erik Clasen-Linde, John Bæch, Thomas Stauffer Larsen, Betina Samuelsen Sørensen, Susanne G. Saekmose, Peter de Nully Brown, Pär Josefsson

Publikováno v: Husby, S, Favero, F, Nielsen, C, Sørensen, B, Bæch, J, Hansen, J W, Gonzalez, G G R, Arboe, B, Andersen, L P, Hastrup, E K, Fischer-Nielsen, A, Saekmose, S G, Hansen, P B, Christiansen, I, Clasen-Linde, E, Knudsen, L M, Grell, K, Segel, E K, Ebbesen, L H, Thorsgaard, M, Josefsson, P L, El-Galaly, T, de Nully Brown, P, Weisenfeldt, J, Larsen, T S & Grønbæk, K 2018, ' Clinical Impact of Clonal Hematopoiesis after Autologous Stem Cell Transplantation for Lymphoma : A National Population-Based Cohort Study ', 60th ASH Annual Meeting & Exposition, San Diego, United States, 01/12/2018-04/12/2018 . < http://ash.confex.com/ash/2018/webprogram/Paper109893.html >
Husby, S, Francesco, F, Nielsen, C, Sorensen, B, Baech, J, Hansen, J W, Gonzalez, G G R, Arboe, B, Andersen, L P, Hastrup, E K, Fischer-Nielsen, A, Saekmose, S G, Hansen, P B, Christiansen, I, Clasen-Linde, E, Knudsen, L M, Grell, K, Segel, E K, Ebbesen, L H, Thorsgaard, M, Josefsson, P L, El-Galaly, T C, Brown, P D N, Weisenfeldt, J, Larsen, T S & Gronbaek, K 2018, ' Clinical Impact of Clonal Hematopoiesis after Autologous Stem Cell Transplantation for Lymphoma: A National Population-Based Cohort Study ', Blood, bind 132, nr. Suppl. 1 . https://doi.org/10.1182/blood-2018-99-109893

Background: Somatic driver mutations in hematopoietic cells may lead to clonal hematopoiesis of indeterminate potential (CHIP). In patients with lymphoma CHIP has been associated with increased risk of therapy-related myeloid neoplasms (tMN) and infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f495ab64e4a567d014790b7c70527275
https://vbn.aau.dk/da/publications/f05c7670-0dd1-47d0-892a-6346ca86c77e

Evaluation of clinical trial eligibility and prognostic indices in a population-based cohort of systemic peripheral T-cell lymphomas from the Danish Lymphoma Registry

Autor: Jakob Madsen, Bo Amdi Jensen, Per Boye Hansen, Stephen Hamilton-Dutoit, Michael Boe Møller, Francesco d'Amore, Elisabeth Ralfkiaer, Claudia Schöllkopf, Peter Nørgaard, Martin Bjerregaard Pedersen, Peter de Nully Brown, Knud Bendix, Preben Johansen

Publikováno v: Hematological Oncology. 33:120-128

Clinical trials (CTs) are needed to improve the outcome for peripheral T-cell lymphomas (PTCL), and accrual into CTs is one of the main recommendations in international treatment guidelines. The use of risk-adapted strategies has been suggested as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::842413388e6aa2d23db4c5eca4cad3b6
https://doi.org/10.1002/hon.2153

Metallothionein-I + II and receptor megalin are altered in relation to oxidative stress in cerebral lymphomas

Autor: Mie Østergaard Pedersen, Per Boye Hansen, Signe Lykke Nielsen, Milena Penkowa

Publikováno v: Leukemia & Lymphoma. 51:314-328

Primary central nervous system lymphoma (PCNSL) in immunocompetent patients is highly malignant and has a poor prognosis. The PCNSL molecular features are reminiscent to some degree of diffuse large B-cell lymphoma (DLBCL), yet PCNSL shows unique mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24426e3c705722b426d573d6d6c44069
https://doi.org/10.3109/10428190903518329