Zobrazeno 1 - 10
of 1 361
pro vyhledávání: '"Per, Svenningsson"'
Autor:
Stefanie Lerche, Isabel Wurster, Enza Maria Valente, Micol Avenali, Daniela Samaniego, Marta Martínez-Vicente, Jorge Hernández-Vara, Ariadna Laguna, Andrea Sturchio, Per Svenningsson, Nicholas P. France, Carrolee Barlow, Sethu Sankaranarayanan, Kathrin Brockmann
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-6 (2024)
Abstract Variants in GBA1 result in dysregulated sphingolipids. We investigated five CSF d18:1 sphingolipid species in a longitudinal multicenter cohort comprising people with Parkinson’s Disease and Dementia with Lewy bodies with and without GBA1
Externí odkaz:
https://doaj.org/article/0432f15037794f51a76f397dcdb3ce10
Autor:
Ioannis Mantas, Ivana Flais, Yuvarani Masarapu, Tudor Ionescu, Solène Frapard, Felix Jung, Pierre Le Merre, Marcus Saarinen, Katarina Tiklova, Behzad Yaghmaeian Salmani, Linda Gillberg, Xiaoqun Zhang, Karima Chergui, Marie Carlén, Stefania Giacomello, Bastian Hengerer, Thomas Perlmann, Per Svenningsson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The Claustrum/dorsal endopiriform cortex complex (CLA) is an enigmatic brain region with extensive glutamatergic projections to multiple cortical areas. The transcription factor Nurr1 is highly expressed in the CLA, but its role in this regi
Externí odkaz:
https://doaj.org/article/f723ec46d21f4e5683d1ae7079739299
Autor:
Josep Argerich, Leonardo D. Garma, Marc López-Cano, Paula Álvarez-Montoya, Laura Gómez-Acero, Víctor Fernández-Dueñas, Ana B. Muñoz-Manchado, Ester Aso, Adam Boxer, Pol Andres-Benito, Per Svenningsson, Francisco Ciruela
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract The orphan G protein-coupled receptor 37 (GPR37), widely associated with Parkinson’s disease (PD), undergoes proteolytic processing under physiological conditions. The N-terminus domain is proteolyzed by a disintegrin and metalloproteinase
Externí odkaz:
https://doaj.org/article/a895c98065b346d388ea55c3a8f58e0d
Autor:
Anna Inguanzo, Rosaleena Mohanty, Konstantinos Poulakis, Daniel Ferreira, Barbara Segura, Franziska Albrecht, J-Sebastian Muehlboeck, Tobias Granberg, Henrik Sjöström, Per Svenningsson, Erika Franzén, Carme Junqué, Eric Westman
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Parkinson’s disease (PD) is clinically heterogeneous, which suggests the existence of subtypes; however, there has been no consensus regarding their characteristics. This study included 633 PD individuals across distinct cohorts: unmedicat
Externí odkaz:
https://doaj.org/article/e3023f14f88547a8b4160c8fa6025208
Autor:
Ellen Appleton, Shervin Khosousi, Michael Ta, Michael Nalls, Andrew B. Singleton, Andrea Sturchio, Ioanna Markaki, Wojciech Paslawski, Hirotaka Iwaki, Per Svenningsson
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/2452f35a07f14ef3a8a8f025c9d8bf2d
Autor:
Martin Paucar, Josephine Wincent, Charlotta Rubin, Kevin Peikert, Josefin Kyhle, Stellan Hertegård, Riita Möller, Soheir Beshara, Per Svenningsson
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Background and objectivesThe diseases historically known as neuroacanthocytosis (NA) conditions include VPS13A disease (formerly chorea-acanthocytosis) and XK disease (formerly McLeod syndrome). Here we report a patient with a hyperkinetic syndrome a
Externí odkaz:
https://doaj.org/article/eae0ba7487144d11b62fd159bba4bb20
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Multiple Sclerosis (MS) is a multifactorial autoimmune disease of the central nervous system (CNS). It is characterized by a heightened activation of the immune system with ensuing inflammation, demyelination and neurodegeneration with consequences s
Externí odkaz:
https://doaj.org/article/bb0776e3fcc847c4af11a8553cf9212b
Autor:
Roberta Filograna, Jule Gerlach, Hae-Na Choi, Giovanni Rigoni, Michela Barbaro, Mikael Oscarson, Seungmin Lee, Katarina Tiklova, Markus Ringnér, Camilla Koolmeister, Rolf Wibom, Sara Riggare, Inger Nennesmo, Thomas Perlmann, Anna Wredenberg, Anna Wedell, Elisa Motori, Per Svenningsson, Nils-Göran Larsson
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Loss-of-function variants in the PRKN gene encoding the ubiquitin E3 ligase PARKIN cause autosomal recessive early-onset Parkinson’s disease (PD). Extensive in vitro and in vivo studies have reported that PARKIN is involved in multiple pat
Externí odkaz:
https://doaj.org/article/5261e43905b84e29a138f193cac7150a
Autor:
Mikkel C. Vinding, Josefine Waldthaler, Allison Eriksson, Cassia Low Manting, Daniel Ferreira, Martin Ingvar, Per Svenningsson, Daniel Lundqvist
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Parkinson’s disease (PD) is associated with changes in neural activity in the sensorimotor alpha and beta bands. Using magnetoencephalography (MEG), we investigated the role of spontaneous neuronal activity within the somatosensory cortex
Externí odkaz:
https://doaj.org/article/24772644ced84906b392dd050e4bac16
Autor:
Silke Nuber, Xiaoqun Zhang, Thomas D. McCaffery, Tim E. Moors, Marie-Alexandre Adom, Wolf N. Hahn, Dylan Martin, Maria Ericsson, Arati Tripathi, Ulf Dettmer, Per Svenningsson, Dennis J. Selkoe
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Mutations in the α-Synuclein (αS) gene promote αS monomer aggregation that causes neurodegeneration in familial Parkinson’s disease (fPD). However, most mouse models expressing single-mutant αS transgenes develop neuronal aggregates ve
Externí odkaz:
https://doaj.org/article/352db539d02c431293173a6ee8a2d72f