Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability

Autor: Elin Movert, Jaume Salgado Bolarin, Christine Valfridsson, Jorge Velarde, Steinar Skrede, Michael Nekludov, Ole Hyldegaard, Per Arnell, Mattias Svensson, Anna Norrby-Teglund, Kyu Hong Cho, Eran Elhaik, Michael R. Wessels, Lars Råberg, Fredric Carlsson

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)

Abstract Variability in disease severity caused by a microbial pathogen is impacted by each infection representing a unique combination of host and pathogen genomes. Here, we show that the outcome of invasive Streptococcus pyogenes infection is regul

Externí odkaz: https://doaj.org/article/e6892bfbcad24fc4a8d136c2cda1ce1b

Hyperbaric oxygen treatment of mandibular osteoradionecrosis:Combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1

Autor: Chris Butterworth, Max J. H. Witjes, Göran Kjeller, Jens Overgaard, Søren Hillerup, Anastasios Kanatas, Lone Forner, Ole Hyldegaard, Jørgen Johansen, Richard Shaw, Matthias A.W. Merkx, Lena Specht, Johannes H.A.M. Kaanders, Christian von Buchwald, Jan Alsner, Erik C. Jansen, F.J. Dieleman, Per Arnell, Ludi E. Smeele

Publikováno v: Forner, L E, Dieleman, F J, Shaw, R J, Kanatas, A, Butterworth, C J, Kjeller, G, Alsner, J, Overgaard, J, Hillerup, S, Hyldegaard, O, Arnell, P, von Buchwald, C, Kaanders, J H A M, Smeele, L E, Specht, L, Johansen, J, Witjes, M J H, Merkx, M A W & Jansen, E C 2022, ' Hyperbaric oxygen treatment of mandibular osteoradionecrosis : Combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1 ', Radiotherapy and Oncology, vol. 166, pp. 137-144 . https://doi.org/10.1016/j.radonc.2021.11.021
Radiotherapy and Oncology, 166, pp. 137-144
Radiotherapy and Oncology
Radiotherapy and Oncology, 166, 137-144
Radiotherapy and Oncology, 166, 137-144. ELSEVIER IRELAND LTD
Radiotherapy and oncology, 166, 137-144. Elsevier Ireland Ltd
Forner, L E, Dieleman, F J, Shaw, R J, Kanatas, A, Butterworth, C J, Kjeller, G, Alsner, J, Overgaard, J, Hillerup, S, Hyldegaard, O, Arnell, P, von Buchwald, C, H A M Kaanders, J, Smeele, L E, Specht, L, Johansen, J, J H Witjes, M, Merkx, M A W & Jansen, E C 2022, ' Hyperbaric oxygen treatment of mandibular osteoradionecrosis: Combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1 ', Radiotherapy and Oncology, vol. 166, pp. 137-144 . https://doi.org/10.1016/j.radonc.2021.11.021

Contains fulltext : 249573.pdf (Publisher’s version ) (Open Access) PURPOSE: Osteoradionecrosis (ORN) of the mandible is a serious complication of head and neck radiotherapy. This study aims to investigate the effect of hyperbaric oxygen (HBO) trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d057f44619d3f7d7cb8253cdbcfbc7
https://curis.ku.dk/portal/da/publications/hyperbaric-oxygen-treatment-of-mandibular-osteoradionecrosis(c2f2671f-76d3-48bc-9b6f-017424c878f4).html

Discriminatory plasma biomarkers predict specific clinical phenotypes of necrotizing soft-tissue infections

Autor: Steinar Skrede, Edoardo Saccenti, Anna Norrby-Teglund, Sanjeevan Jahagirdar, Mattias Svensson, Michael Nekludov, Marco Bo Hansen, Vitor A. P. Martins dos Santos, Per Arnell, Ole Hyldegaard, Eivind Rath, Laura M Palma Medina, Martin Bruun Madsen, Christian Unge, Magda Lourda, Trond Bruun, Kristoffer Strålin

Publikováno v: Palma Medina, L M, Rath, E, Jahagirdar, S, Bruun, T, Madsen, M B, Strålin, K, Unge, C, Hansen, M B, Arnell, P, Nekludov, M, Hyldegaard, O, Lourda, M, Martins dos Santos, V A P, Saccenti, E, Skrede, S, Svensson, M & Norrby-Teglund, A 2021, ' Discriminatory plasma biomarkers predict specific clinical phenotypes of necrotizing soft-tissue infections ', Journal of Clinical Investigation, vol. 131, no. 14, e149523 . https://doi.org/10.1172/JCI149523
Journal of Clinical Investigation, 131(14)
Journal of Clinical Investigation 131 (2021) 14
The Journal of Clinical Investigation

BACKGROUND Necrotizing soft-tissue infections (NSTIs) are rapidly progressing infections frequently complicated by septic shock and associated with high mortality. Early diagnosis is critical for patient outcome, but challenging due to vague initial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947270e8a03511ba32bd98fb21d087be
https://doi.org/10.1172/jci149523

Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections

Autor: Andreas Itzek, Ole Hyldegaard, Martin Bruun Madsen, Steinar Skrede, Oddvar Oppegaard, Mattias Svensson, Francois Bergey, Per Arnell, Anna Norrby-Teglund, Helena Bergsten, Anders Perner

Publikováno v: Bergsten, H, Madsen, M B, Bergey, F, Hyldegaard, O, Skrede, S, Arnell, P, Oppegaard, O, Itzek, A, Perner, A, Svensson, M, Norrby-Teglund, A & INFECT Study Group 2020, ' Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections ', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 71, no. 7, pp. 1772-1775 . https://doi.org/10.1093/cid/ciaa022
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Analyses of plasma collected pre- and postadministration of intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e757403026d7eaa7ba683c2d4b73f8f
https://curis.ku.dk/portal/da/publications/correlation-between-immunoglobulin-dose-administered-and-plasma-neutralization-of-streptococcal-superantigens-in-patients-with-necrotizing-soft-tissue-infections(1c3683be-3aa9-4a32-abb2-82db4c8a3eaf).html

[Introduction of prehospital blood transfusion programme in Sweden: experiences from a physician staffed helicopter emergency medical service]

Autor: José-Gabriel, Sato Folatre, Per, Arnell, Mari, Henning, Kristina, Josefsson, Gabriel, Skallsjö, Sven-Erik, Ricksten

Publikováno v: Lakartidningen. 115

In 2016, physician staffed helicopter emergency medical service (VGR HEMS) became the first Swedish prehospital service to routinely carry and transfuse red blood cells. In this report we describe our implementation and present our results, with prel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8bb85630d40c19a6368780b15b7d154e
https://pubmed.ncbi.nlm.nih.gov/30299527