Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Peptidyltransferase activity"'
Autor:
Smaragda Tselika
In present study, we investigated the role of helix h44 of 18S rRNA of Saccharomyces cerevisiae on several parameters of protein synthesis. For this purpose we employed mutations A1491G (rdn15) and U1495C (rdnhyg1) which are located in the A-site of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74f64f933ee1170379ed8743a4be4f5a
https://doi.org/10.12681/eadd/27728
https://doi.org/10.12681/eadd/27728
Publikováno v:
Biochimie. 90:908-917
Two mutations in the A-site of 18S rRNA of Saccharomyces cerevisiae were investigated. The first, A1491G (rdn15), creates in yeast the same C1409-G1491 base pair as in Escherichia coli and has behaved as an antisuppressor in genetic studies. Ribosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bd7374abf8f50bfc0f60c87571b686
https://doi.org/10.1016/j.biochi.2008.02.010
https://doi.org/10.1016/j.biochi.2008.02.010
Publikováno v:
Nucleic Acids Research
Ribosomal protein L2 is a core element of the large subunit that is highly conserved among all three kingdoms. L2 contacts almost every domain of the large subunit rRNA and participates in an intersubunit bridge with the small subunit rRNA. It contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c40593f372ab87487e36b82f1e0618
https://doi.org/10.1093/nar/gkn034
https://doi.org/10.1093/nar/gkn034
Autor:
Alexander S. Spirin
Publikováno v:
RNA Biology. 1:2-8
The ribosome is a protein-synthesizing ribonucleoprotein particle where RNA forms its structural and functional core. Compact self-folding of ribosomal RNA resulting in its specific tertiary structure and its conformational mobility underlie the func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db4fad7d3567f72762f440a58dd710d4
https://doi.org/10.4161/rna.1.1.889
https://doi.org/10.4161/rna.1.1.889
Publikováno v:
Nucleic Acids Research. 31:5074-5083
Chloramphenicol is thought to interfere competitively with the binding of the aminoacyl-tRNA 3'-terminus to ribosomal A-site. However, noncompetitive or mixed-noncompetitive inhibition, often observed to be dependent on chloramphenicol concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec356056a1b73aa2982a2a8ea5b08de
https://doi.org/10.1093/nar/gkg686
https://doi.org/10.1093/nar/gkg686
Publikováno v:
RNA
Increased efficiencies of programmed −1 ribosomal frameshifting in yeast cells expressing mutant forms of ribosomal protein L3 are unable to maintain the dsRNA “Killer” virus. Here we demonstrate that changes in frameshifting and virus maintena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae0418490b58f984cfe0b988d596f41
Autor:
Yong Ping Yan, Ekaterina V. Bobkova, David L. Pompliano, Douglas B. Jordan, Michael G. Kurilla
Publikováno v:
Journal of Biological Chemistry. 278:9802-9807
Kinetic analysis of ribosomal peptidyltransferase activity in a methanolic puromycin reaction with wild type and drug-resistant 23 S RNA mutants was used to probe the structural basis of catalysis and mechanism of resistance to antibiotics. 23 S RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd556ce5fba6bb7481993b64e1c16c0
https://doi.org/10.1074/jbc.m209249200
https://doi.org/10.1074/jbc.m209249200
Publikováno v:
Journal of Biological Chemistry. 278:3314-3322
Yeast ribosomal protein L41 is dispensable in the yeast. Its absence had no effect on polyphenylalanine synthesis activity, and a limited effect on growth, translational accuracy, or the resistance toward the antibiotic paromomycin. Removal of L41 di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb0172d2b8cf8e5de56ec70d8f34c7e
https://doi.org/10.1074/jbc.m207533200
https://doi.org/10.1074/jbc.m207533200
Autor:
Eric Cundliffe
Publikováno v:
The Ribosome
Antibiotics are synthesized by dedicated gene products; they are anything but accidents. All the structural genes required for tylosin biosynthesis are probably present in the cluster, but additional regulatory genes might well be located elsewhere i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54c25938998e3ceca940f0664fbeb2f9
https://doi.org/10.1128/9781555818142.ch33
https://doi.org/10.1128/9781555818142.ch33
Publikováno v:
The Ribosome
RNA plays a critical role in all the steps of protein synthesis. The idea that the modern ribosome evolved from the original RNA-only protein-synthesizing machinery was so appealing, and made so much sense from the evolutionary standpoint, that it im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4da567ca04f4d00caa8b057f2dff49c3
https://doi.org/10.1128/9781555818142.ch20
https://doi.org/10.1128/9781555818142.ch20