Relationship between the structure of synthetic organic molecules, their behavior in the phospholipid membrane and their effect on bacteria

Autor: Brzobohatá, Hana

Lipophoshopnoxins (LPPOs) are organic compounds with antimicrobial activity, which take place on the baterial membrane by forming pores. LPPOs are promising bactericidal molecules with low MIC (minimal inhibition concentration) and high HC50 (hemolyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2186::ddbfb1f218265354be04d778644941c0
http://www.nusl.cz/ntk/nusl-509900

Mimetics of polypeptide hormones from the insulin family

Autor: Mařík, Vojtěch

1 The family of human insulin-like peptide hormones includes insulin, insulin-like growth factors 1 and 2 (IGF-1 and 2), relaxins 1-3, and INSL3-6 polypeptides. These polypeptide hormones share similar 3D structures while retaining a similar disulfid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2186::fac5fa7db9d7f9e1addd9db05fcbba68
http://www.nusl.cz/ntk/nusl-446141

Synthesis and conformational analysis of peptidomimetics containing unnatural amino acids based on a piperazinone and gamma-butyrolactone scaffolds

Autor: Guitot, Karine

The design and synthesis of conformationally restrained amino acids has been the focus of extensive research, because these compounds mimic or induce specific secondary structural features of peptides and proteins. Since the discovery of the crucial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1caf0e7f06096e85c901a97448cb4b27

Carbohydrate-Based Mimetics in Drug Design

Autor: Gruner, Sibylle Annette Wunneda

A straightforward synthesis of the two new furanoid sugar amino acids f-SAA 106 and f-SAA 107 in high yields in a few steps from glucose was developed. The described new synthetic pathway allows an easy access to f-SAA 106 and f-SAA 107, making them

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______518::8885aedb45d90988f972071810f3ca43
https://mediatum.ub.tum.de/doc/601219/document.pdf

Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions.

Autor: Barnard A; School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT (UK); Astbury Centre For Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT (UK)., Long K; School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT (UK); Astbury Centre For Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT (UK)., Martin HL; Leeds Institute of Biomedical and Clinical Sciences, Wellcome Trust Brenner Building, University of Leeds, St. James's University Hospital, Leeds LS9 7TF (UK)., Miles JA; School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT (UK); Astbury Centre For Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT (UK)., Edwards TA; Astbury Centre For Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT (UK); School of Molecular and Cellular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT (UK)., Tomlinson DC; Astbury Centre For Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT (UK); School of Molecular and Cellular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT (UK)., Macdonald A; Astbury Centre For Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT (UK); School of Molecular and Cellular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT (UK)., Wilson AJ; School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT (UK); Astbury Centre For Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT (UK).

Publikováno v: Angewandte Chemie (Weinheim an der Bergstrasse, Germany) [Angew Chem Weinheim Bergstr Ger] 2015 Mar 02; Vol. 127 (10), pp. 3003-3008. Date of Electronic Publication: 2015 Jan 30.