Low-Molecular-Mass Fragments of Collagen Improve Parameters Related to Mass and Inflammation of the Adipose Tissue in the Obese Rat

Autor: Olesia Kalmukova, Nataliia Raksha, Tetiana Vovk, Tetiana Halenova, Mykola Dzerzhynsky, Dinko Mitrecic, Olexiy Savchuk, Ludmila Ostapchenko

Publikováno v: Food Technology and Biotechnology
Volume 61
Issue 1

Research background. Despite clearly recognized links between increased body mass and increased risk for various pathological conditions, therapeutic options to treat obesity are still very limited. The aim of the present study is to explore the effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dff8dc890c6a872a256b97ff5642375
https://doi.org/10.17113/ftb.61.01.23.7926

Heterobifunctional ligase recruiters enable pan-degradation of inhibitor of apoptosis proteins

Autor: Yuen Lam Dora Ng, Aleša Bricelj, Jacqueline A. Jansen, Arunima Murgai, Kirsten Peter, Katherine A. Donovan, Michael Gütschow, Jan Krönke, Christian Steinebach, Izidor Sosič

Publikováno v: Journal of medicinal chemistry, vol. 66, no. 7, pp. 4703-4733, 2023.
Journal of medicinal chemistry, str. 4703-4733 : Ilustr., Vol. 66, iss. 7, 2023
COBISS-ID: 512806681

Proteolysis targeting chimeras (PROTACs) represent a new pharmacological modality to inactivate disease-causing proteins. PROTACs operate via recruiting E3 ubiquitin ligases, which enable the transfer of ubiquitin tags onto their target proteins, lea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e25f1087502a057345c9d203428b453
https://hdl.handle.net/20.500.12556/RUL-145892

Construction of focused cyclic peptide phage library and affinity selection of human immunoglobulin G ligands

Autor: Gnidovec, Klemen

Monoklonska protitelesa so zaradi velike specifičnosti in afinitete vezave pomemben del terapije in diagnostike številnih bolezni. Proizvajamo jih s tehnologijo rekombinantne DNA v sesalskih celicah, ključna pri njihovi izolaciji iz fermentacijske

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3505::fe89365f5d712a6a369e53bbada3029b
https://hdl.handle.net/20.500.12556/RUL-147027

Usporedba prognostičke vrijednosti atrijskog električkog potencijala i razine natriuretičkih peptida na pojavu asimptomatske fibrilacije atrija kod bolesnika s totalnim atrioventrikulskim blokom i elektrostimulatorom srca

Autor: Radeljić, Vjekoslav

Ovim radom nastojalo se definirati učestalost asimptomatske fibrilacije atrija kod homogene skupine bolesnika. To su bolesnici s jednom indikacijom za elektrostimulaciju tj. bolesnici s totalnim atrioventrikulskim blokom. Iz istraživanja su isklju�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cb5c00fa6e19ebd9ae992aad9e3a1259
https://urn.nsk.hr/urn:nbn:hr:105:473833

Synthesis and structural characterization of methyl 1-aminoferrocene-1-carboxylate conjugates with prolyl-alanine dipeptide

Autor: Šimunović, Lucija

Peptidomimetici u odnosu na prirodne peptide formiraju rigidniju strukturu i daleko su konformacijski i proteolitički stabilniji, što im omogućuje primjenu u dizajnu i sintezi lijekova i biološki aktivnih spo-jeva. „Zaključavanje“ peptidomim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::babb18729b023fdec69c8119e8afccfd
https://repozitorij.pbf.unizg.hr/islandora/object/pbf:4440/datastream/PDF