Transcriptional re-programming of insulin B-chain epitope-specific T-follicular helper cells into anti-diabetogenic T-regulatory type-1 cells

Autor: Patricia Solé, Daniel Parras, Jun Yamanouchi, Josep Garnica, Nahir Garabatos, Joel Moro, Javier Montaño, Debajyoti Mondal, César Fandos, Yang Yang, Pau Serra, Pere Santamaria

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Systemic delivery of nanoparticles (NPs) coated with mono-specific autoimmune disease-relevant peptide-major histocompatibility complex class II (pMHCII) molecules can resolve organ inflammation in various disease models in a disease-specific manner

Externí odkaz: https://doaj.org/article/85c9e4b9a8e44dcfae571bff682908fe

Increased peptide contacts govern high affinity binding of a modified TCR whilst maintaining a native pMHC docking mode

Autor: David Kenneth Cole

Publikováno v: Frontiers in Immunology, Vol 4 (2013)

Natural TCRs generally bind to their cognate pMHC molecules with weak affinity and fast kinetics, limiting their use as therapeutic agents. Using phage display, we have engineered a high affinity version of the A6 wildtype TCR (A6wt), specific for th

Externí odkaz: https://doaj.org/article/bee5211a965c42038dc9b6becd447248

TCR-induced alteration of primary MHC peptide anchor residue

Autor: Florian, Madura, Pierre J, Rizkallah, Mateusz, Legut, Christopher J, Holland, Anna, Fuller, Anna, Bulek, Andrea J, Schauenburg, Andrew, Trimby, Jade R, Hopkins, Stephen A, Wells, Andrew, Godkin, John J, Miles, Malkit, Sami, Yi, Li, Nathaniel, Liddy, Bent K, Jakobsen, E Joel, Loveridge, David K, Cole, Andrew K, Sewell

Publikováno v: European Journal of Immunology

The HLA‐A*02:01‐restricted decapeptide EAAGIGILTV, derived from melanoma antigen recognized by T‐cells‐1 (MART‐1) protein, represents one of the best‐studied tumor associated T‐cell epitopes, but clinical results targeting this peptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4cdfe2ebbf2aa64cc7714dc26e19d1ee
https://pubmed.ncbi.nlm.nih.gov/31091334

Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase

Autor: Cole, David K, Wooldridge, Linda, Sewell, Andrew K

Publikováno v: Cole, D K, Wooldridge, L & Sewell, A K 2017, ' Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase ', Journal of Biological Chemistry, vol. 292, pp. 802-813 . https://doi.org/10.1074/jbc.M116.741603

T-cell cross-reactivity is essential for effective immune surveillance, but has alsobeen implicated as a pathway to autoimmunity. Previous studies have demonstrated that T-cell receptors (TCRs) that focus on a minimal motif within the peptide are abl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2642::6dfbc15199464c156cc5f8714220265a
https://research-information.bris.ac.uk/ws/files/101727881/J._Biol._Chem._2017_Cole_802_13.pdf

Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes

Autor: Jan W. Drijfhout, Robin R. Knight, David K. Cole, Jamie Rossjohn, John J. Miles, Nikolai Lissin, Stephanie Gras, Anna Marta Bulek, Peter Eamon Molloy, Guo Cai Huang, Pierre J. Rizkallah, Florian Madura, Ania Skowera, Mark Peakman, Andrew K. Sewell, Bent K. Jakobsen, Anna Fuller, David Price, Linda Wooldridge, Emma Gostick, Garry Dolton

Publikováno v: Nature Immunology, 13(3), 283-U1521
Nature immunology
ResearcherID

The structural characteristics of the engagement of major histocompatibility complex (MHC) class II-restricted self antigens by autoreactive T cell antigen receptors (TCRs) is established, but how autoimmune TCRs interact with complexes of self pepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4160935535fa6c06c93af5c7ca554f4b
https://doi.org/10.1038/ni.2206