Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Peptide stabilization"'
Autor:
Benedikt Judmann, Nils F. Baier, Henning Rudolf, Güllü Davarci, Björn Wängler, Ralf Schirrmacher, Gert Fricker, Carmen Wängler
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 12, Iss , Pp 100223- (2024)
The neuropeptide Y receptor subtype 1 (NPY(Y1)R) exhibits high expression rates on human breast cancer and is therefore an important target structure for the sensitive and specific visualization and characterization of the disease by Positron Emissio
Externí odkaz:
https://doaj.org/article/4d3a1d0a7d4c46b8be7c6dc3cbfb18a1
Akademický článek
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Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2045-2056 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Highlights • Mechanism of CKII peptide recognition, transportation and binding in OGT is obtained. • Peptide delivery is strong exothermic, highly dependent on hydrogen bond network. • Typical ‘spread’ & ‘V’ conf
Highlights • Mechanism of CKII peptide recognition, transportation and binding in OGT is obtained. • Peptide delivery is strong exothermic, highly dependent on hydrogen bond network. • Typical ‘spread’ & ‘V’ conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee748fea77a9325fb56f9573291a66d
http://www.sciencedirect.com/science/article/pii/S2001037021001203
http://www.sciencedirect.com/science/article/pii/S2001037021001203
Autor:
Shiyan Cheng, Chandra S. Verma, Yaqi Chen, Yibing Zhao, Tao Li, Jianguo Li, Jinghui Wang, Chuanliu Wu
Publikováno v:
Organic & Biomolecular Chemistry. 15:1921-1929
Peptides have been promising molecular scaffolds for the development of potential therapeutics with high affinity and specificity to biomacromolecules. However, their inherent proteolytic instability significantly hampers their biological application
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621a60bc659941e5f555c4292a0a210c
https://doi.org/10.1039/c6ob02786e
https://doi.org/10.1039/c6ob02786e
Publikováno v:
MedChemComm. 7:1640-1646
Radiometallated regulatory peptides are a promising class of radiopharmaceuticals for the diagnosis (imaging) and therapy of cancer in nuclear oncology. A limitation of such peptides employed as tumor-specific vectors is represented by their low stab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66dd9c6a313f3e2bef1357b6706f6d0e
https://doi.org/10.1039/c6md00208k
https://doi.org/10.1039/c6md00208k
Publikováno v:
Journal of chemical theory and computation. 12(9)
Due to antimicrobial resistance, the development of new drugs to combat bacterial and fungal infections is an important area of research. Nature uses short, charged, and amphipathic peptides for antimicrobial defense, many of which disrupt the lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c5ebcbe7ca8de86bcdafd1650092fe
https://pubmed.ncbi.nlm.nih.gov/27529120
https://pubmed.ncbi.nlm.nih.gov/27529120
Akademický článek
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Autor:
Regina Gilman-Politi, Daniel Harries
Publikováno v:
Journal of Chemical Theory and Computation. 7:3816-3828
Many polyols and carbohydrates serve in different organisms as protective osmolytes that help to stabilize proteins in their native, functional state, even under a variety of environmental stresses. However, despite their important role, much of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f54d2007192d82ad429a8242f96509b
https://doi.org/10.1021/ct200455n
https://doi.org/10.1021/ct200455n
Publikováno v:
The Journal of Physical Chemistry B. 115:4234-4243
Electrostatic interactions between side chains can control the conformation and folding of peptides and proteins. We used circular dichroism (CD) and ultraviolet (UV) resonance Raman spectroscopy (UVRR) to examine the impact of side chain charge on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf37d51286c3f2fe6bf86dcc10a32b34
https://doi.org/10.1021/jp112238q
https://doi.org/10.1021/jp112238q
Publikováno v:
Drug Delivery. 17:605-616
Proteins and peptides are complex macromolecules that are prone to change in their native structure during storage, which causes undesired side-effects after their administration. During past decades, bioactive carriers have played an important role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdee61a5a9bcc12e46f40f0d4a46a53f
https://doi.org/10.3109/10717544.2010.509359
https://doi.org/10.3109/10717544.2010.509359