Zobrazeno 1 - 10
of 1 708
pro vyhledávání: '"Peptide inhibitor"'
Autor:
Ying Yi, Lingfeng Dai, Yaqin Lan, Changyuan Tan, Dania M. Vázquez-Blomquist, Guirong Zeng, Dejian Jiang, Ke Yang, Silvio E. Perea, Yasser Perera
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Overall response rates in advanced Non-Small Cell Lung Cancer (NSCLC) remains low. Thus, novel molecular targets, tailored drugs and/or drug combinations are needed. Casein Kinase-2 (CK2) is a constitutively active and frequently over-expres
Externí odkaz:
https://doaj.org/article/1bd07b02822f46a19511f025136c0657
Publikováno v:
Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 44, Iss 5, Pp 567-575 (2024)
Objective·To establish various in vitro screening systems for the discovery of peptide inhibitors targeting the interaction between small ubiquitin-like modifier (SUMO)-activating enzyme subunit 1 (SAE1) and subunit 2 (SAE2), as well as to evaluate
Externí odkaz:
https://doaj.org/article/cfb09fa04b244325a9d9e9be93fb8d6e
Autor:
Mohammad Sadegh Taghizadeh, Mohsen Taherishirazi, Ali Niazi, Alireza Afsharifar, Ali Moghadam
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
CDK9 (cyclin-dependent kinase 9) plays a significant role in numerous pathological conditions, such as HIV-1 infection and cancer. The interaction between CDK9 and cyclin T1 is crucial for maintaining the kinase’s active state. Therefore, targeting
Externí odkaz:
https://doaj.org/article/db99f16401dd4e4da5767dbdc534d797
Autor:
Yanxin Gai, Sizhu Duan, Shiqi Wang, Kaifeng Liu, Xin Yu, Chumeng Yang, Guoqing Li, Yan Zhou, Bin Yu, Jiaxin Wu, Chu Wang, Xianghui Yu
Publikováno v:
Viruses, Vol 16, Iss 4, p 490 (2024)
One of the major functions of the accessory protein Vif of human immunodeficiency virus type 1 (HIV-1) is to induce the degradation of APOBEC3 (A3) family proteins by recruiting a Cullin5-ElonginB/C-CBFβ E3 ubiquitin ligase complex to facilitate vir
Externí odkaz:
https://doaj.org/article/6479b387a255468497f7176b73e84512
Autor:
Toshiya Oba, Daiki Homma, Sophia Jobien M. Limlingan, Aoi Fukuchi, Akiko Asada, Taro Saito, Kanae Ando
Publikováno v:
Neurobiology of Disease, Vol 188, Iss , Pp 106334- (2023)
Abnormal activation of microtubule affinity-regulating kinase 4 (MARK4) and its phosphorylation of the microtubule-associated protein tau are believed to play a role in the pathogenesis of Alzheimer's disease, and MARK4 inhibition can be a strategy t
Externí odkaz:
https://doaj.org/article/666cf8a5f97343cc86ca130d2390aa1c
Autor:
Guo-Qing Tang, Yalan Tang, Ketki Dhamnaskar, Michelle D. Hoarty, Rohit Vyasamneni, Douangsone D. Vadysirisack, Zhong Ma, Nanqun Zhu, Jian-Guo Wang, Charlie Bu, Bestine Cong, Elizabeth Palmer, Petra W. Duda, Camil Sayegh, Alonso Ricardo
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/fbb275fe49cf40f593ad242e926307dc
Autor:
Katarzyna Kuncewicz, Magdalena Bojko, Claire Battin, Agnieszka Karczyńska, Adam Sieradzan, Emilia Sikorska, Katarzyna Węgrzyn, Karolina Wojciechowicz, Anna Wardowska, Peter Steinberger, Sylwia Rodziewicz-Motowidło, Marta Spodzieja
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115161- (2023)
Immune checkpoints can be divided into co-stimulatory and co-inhibitory molecules that regulate the activation and effector functions of T cells. The co-inhibitory pathways mediated by ICPs are used by cancer cells to escape from immune surveillance,
Externí odkaz:
https://doaj.org/article/871470036cfc451ab2904d5eaa053c2c
Publikováno v:
Exploration of Medicine, Vol 4, Iss 1, Pp 85-106 (2023)
Neuropathic pain (NP) remains maltreated for a wide number of patients by the currently available treatments and little research has been done in finding new drugs for treating NP. Ziconotide (PrialtTM) had been developed as the new drug, which belon
Externí odkaz:
https://doaj.org/article/c7570e857c6c4e47b81eaf2cdc4860b9
Autor:
Guo-Qing Tang, Yalan Tang, Ketki Dhamnaskar, Michelle D. Hoarty, Rohit Vyasamneni, Douangsone D. Vadysirisack, Zhong Ma, Nanqun Zhu, Jian-Guo Wang, Charlie Bu, Bestine Cong, Elizabeth Palmer, Petra W. Duda, Camil Sayegh, Alonso Ricardo
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe complement system is a key component of the innate immune system, and its aberrant activation underlies the pathophysiology of various diseases. Zilucoplan is a macrocyclic peptide that binds and inhibits the cleavage/activation of hu
Externí odkaz:
https://doaj.org/article/04a48afd569947a08aee94bcb0ee1d74
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