Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Peptide amidation"'
Autor:
John Donlon, Patrick Ryan
Publikováno v:
Heliyon, Vol 5, Iss 9, Pp e02436- (2019)
C-terminal α-amidation of peptides is an important event in the course of pro-hormone and neuropeptide processing; it is a modification that contributes to the biological activity and stability of about 25 peptides in neural and endocrine systems. T
Externí odkaz:
https://doaj.org/article/066269fb4f13460cadd31c2a82b5fdfd
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
C-terminal α-amidation is the final and essential step in the biosynthesis of several peptide hormones. Peptidylglycine α-amidating monooxygenase (PAM) is the only known enzyme to catalyse this reaction. PAM amidating activity (AMA) is known to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57718d280b57a071fa600aca328c34a6
https://doi.org/10.1038/s41598-021-95305-y
https://doi.org/10.1038/s41598-021-95305-y
Publikováno v:
Annals of Hematology. 97:1527-1534
Copper is a crucial micronutrient needed by animals and humans for proper organ function and metabolic processes such as hemoglobin synthesis, as a neurotransmitter, for iron oxidation, cellular respiration, and antioxidant defense peptide amidation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e82c61c61418ead85ff58c937d7234e
https://doi.org/10.1007/s00277-018-3407-5
https://doi.org/10.1007/s00277-018-3407-5
Autor:
Rasmus Linde Bang Elnegaard, Qiang Zhang, Niels Erik Møllegaard, Frank Kjeldsen, Thomas J. D. Jørgensen
Publikováno v:
Elnegaard, R L B, Møllegaard, N E, Zhang, Q, Kjeldsen, F & Jørgensen, T J D 2017, ' Uranyl Photocleavage of Phosphopeptides Yields Truncated C-Terminally Amidated Peptide Products ', ChemBioChem, vol. 18, no. 12, pp. 1117-1122 . https://doi.org/10.1002/cbic.201700103
Chembiochem
ChemBioChem
Chembiochem
ChemBioChem
The uranyl ion (UO2(2+) ) binds phosphopeptides with high affinity, and when irradiated with UV-light, it can cleave the peptide backbone. In this study, high-accuracy tandem mass spectrometry and enzymatic assays were used to characterise the photoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5beb9f49612ed93b865eba0490f86bea
https://doi.org/10.1002/cbic.201700103
https://doi.org/10.1002/cbic.201700103
Autor:
Traci A. Czyzyk, Betty A. Eipper, C. Bruce Verchere, Yi-Chun Chen, Richard E. Mains, Brad G. Hoffman, John E. Pintar
Publikováno v:
Diabetologia
AIMS/HYPOTHESIS: Peptide hormones are first synthesised as larger, inactive precursors that are converted to their active forms by endopeptidase cleavage and post-translational modifications, such as amidation. Recent, large-scale genome-wide studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c49c29b198a14b91de9e6359d8e2ec9
https://pubmed.ncbi.nlm.nih.gov/32172312
https://pubmed.ncbi.nlm.nih.gov/32172312
Publikováno v:
Journal of Biological Chemistry. 291:9835-9850
Peptidylglycine α-amidating monooxygenase (PAM) (EC 1.14.17.3) catalyzes peptide amidation, a crucial post-translational modification, through the sequential actions of its monooxygenase (peptidylglycine α-hydroxylating monooxygenase) and lyase (pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306b222a9b636ad4253505bf62d90397
https://doi.org/10.1074/jbc.m115.711838
https://doi.org/10.1074/jbc.m115.711838
Autor:
Patrick Ryan, John Donlon
Publikováno v:
Heliyon, Vol 5, Iss 9, Pp e02436-(2019)
Heliyon
Heliyon
C-terminal α-amidation of peptides is an important event in the course of pro-hormone and neuropeptide processing; it is a modification that contributes to the biological activity and stability of about 25 peptides in neural and endocrine systems. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a63fc3ebabc1a14a87274074caf5cc4
https://doi.org/10.1016/j.heliyon.2019.e02436
https://doi.org/10.1016/j.heliyon.2019.e02436
Akademický článek
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Publikováno v:
Asian Journal of Pharmaceutical and Clinical Research. 11:30
Ascorbic acid (AA) or Vitamin C is an important antioxidant which participates in numerous cellular functions. Although in human plasma its concentration is in micromolars but it reaches millimolar concentrations in most of the human tissues. The hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1661c079f147b5501db463fba1b373f6
https://doi.org/10.22159/ajpcr.2018.v11i10.27318
https://doi.org/10.22159/ajpcr.2018.v11i10.27318
Autor:
Betty A. Eipper, Traci A. Czyzyk, Eduardo A. Nillni, Danielle Bousquet-Moore, Joseph R. Prohaska, Richard E. Mains, William C. Wetsel
Publikováno v:
Neurobiology of Disease, Vol 37, Iss 1, Pp 130-140 (2010)
Mammalian genomes encode only a small number of cuproenzymes. The many genes involved in coordinating copper uptake, distribution, storage and efflux make gene/nutrient interactions especially important for these cuproenzymes. Copper deficiency and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905476c880b4ca5e2abbf06148bf3fb2
https://doi.org/10.1016/j.nbd.2009.09.016
https://doi.org/10.1016/j.nbd.2009.09.016