Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Peptide Aβ"'
Autor:
Tsu-Kung Lin, Chi-Ren Huang, Kai-Jung Lin, Yi-Heng Hsieh, Shang-Der Chen, Yi-Chun Lin, A-Ching Chao, Ding-I Yang
Publikováno v:
Antioxidants, Vol 13, Iss 11, p 1378 (2024)
The major pathological characteristics of Alzheimer’s disease (AD) include senile plaques and neurofibrillary tangles (NFTs), which are mainly composed of aggregated amyloid-beta (Aβ) peptide and hyperphosphorylated tau protein, respectively. The
Externí odkaz:
https://doaj.org/article/3ec10bfd3daa46cd8efc27baa4f42ee8
Autor:
Yu Jung Shin, Kira M. Evitts, Solhee Jin, Caitlin Howard, Margaret Sharp-Milgrom, Tiara Schwarze-Taufiq, Chizuru Kinoshita, Jessica E. Young, Ying Zheng
Publikováno v:
Neurobiology of Disease, Vol 181, Iss , Pp 106125- (2023)
In Alzheimer's disease (AD), secretion and deposition of amyloid beta peptides (Aβ) have been associated with blood-brain barrier dysfunction. However, the role of Aβ in endothelial cell (EC) dysfunction remains elusive. Here we investigated AD med
Externí odkaz:
https://doaj.org/article/66fad72055314b8f957aa0994355878c
Autor:
Davidson, Darcy Shanley
Amyloidogenic diseases, such as Alzheimer's disease (AD) and Type II Diabetes (T2D), are characterized by the accumulation of amyloid aggregates. Despite having very different amino-acid sequences, the underlying amyloidogenic proteins form similar s
Externí odkaz:
http://hdl.handle.net/10919/109669
Autor:
Silvia Hilt, Ruiwu Liu, Izumi Maezawa, Tatu Rojalin, Hnin H. Aung, Madhu Budamagunta, Ryan Slez, Qizhi Gong, Randy P. Carney, John C. Voss
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Several neurodegenerative diseases are driven by misfolded proteins that assemble into soluble aggregates. These “toxic oligomers” have been associated with a plethora of cellular dysfunction and dysregulation, however the structural features und
Externí odkaz:
https://doaj.org/article/575a1b403849475ca12a31cf7a3d0cda
Akademický článek
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Autor:
Cecile Feuillie, Eleonore Lambert, Maxime Ewald, Mehdi Azouz, Sarah Henry, Sophie Marsaudon, Christophe Cullin, Sophie Lecomte, Michael Molinari
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Due to an aging population, neurodegenerative diseases such as Alzheimer’s disease (AD) have become a major health issue. In the case of AD, Aβ1–42 peptides have been identified as one of the markers of the disease with the formation of senile p
Externí odkaz:
https://doaj.org/article/b73bc4ad68814f73b74f8e4f9bf4e003
Autor:
Chenxi Feng, Xiaoming Bao, Ling Shan, Yunxiang Ling, Yanfei Ding, Jia Wang, Yanzi Cao, Qinwen Wang, Wei Cui, Shujun Xu
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCRs). Soluble β-amyloid peptide (Aβ) is one of the orthosteric modulators of CaSR, while, the role and underlying mechanism of CaSR in cognitive decline in Alzheimer’s disease (AD
Externí odkaz:
https://doaj.org/article/e5497354b0274e3baacee524cc4d6f14
Publikováno v:
Biomolecular Concepts, Vol 8, Iss 1, Pp 37-43 (2017)
Alzheimer’s disease (AD) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and hyperphosphorylated tau protein, activated microglia and neuronal cell death, ultimately leading to progressive dementia.
Externí odkaz:
https://doaj.org/article/77ea4adf46294e9891b83d695005b723
Autor:
Amadoro, Valentina Latina, Anna Atlante, Francesca Malerba, Federico La Regina, Bijorn Omar Balzamino, Alessandra Micera, Annabella Pignataro, Egidio Stigliano, Sebastiano Cavallaro, Pietro Calissano, Giuseppina
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9683
Beyond deficits in hippocampal-dependent episodic memory, Alzheimer’s Disease (AD) features sensory impairment in visual cognition consistent with extensive neuropathology in the retina. 12A12 is a monoclonal cleavage specific antibody (mAb) that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::484dd7c1a4d29923e9d34f13d2659df2
Publikováno v:
Journal of Functional Foods, Vol 20, Iss , Pp 567-574 (2016)
Inhibition of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) has emerged as a prime target in Alzheimer's disease research because BACE1 is the rate-limiting enzyme involved in the abnormal production of β-amyloid peptides. In the cours
Externí odkaz:
https://doaj.org/article/a0ccb41f616049018652cd03a1745ae1