Cortical neurons obtained from patient-derived iPSCs with GNAO1 p.G203R variant show altered differentiation and functional properties.

Autor: Benedetti MC; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy.; Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), Rome, Italy., D'andrea T; Department of Physiology and Pharmacology 'V. Erspamer', Sapienza University of Rome, Rome, Italy., Colantoni A; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy.; Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), Rome, Italy., Silachev D; School of Medicine and Life Sciences, Far Eastern Federal University, 690090, Vladivostok, Russia.; A.N. Belozersky Research Institute of Physico-Chemical Biology, Moscow State University, 119992, Moscow, Russia.; Department of Cell Physiology and Metabolism, Faculty of Medicine, Translational Research Center in Oncohaematology, University of Geneva, 1211, Geneva, Switzerland., de Turris V; Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), Rome, Italy., Boussadia Z; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy., Babenko VA; A.N. Belozersky Research Institute of Physico-Chemical Biology, Moscow State University, 119992, Moscow, Russia.; Department of Cell Physiology and Metabolism, Faculty of Medicine, Translational Research Center in Oncohaematology, University of Geneva, 1211, Geneva, Switzerland., Volovikov EA; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435, Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435, Moscow, Russia., Belikova L; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435, Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435, Moscow, Russia., Bogomazova AN; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435, Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435, Moscow, Russia., Pepponi R; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy., Whye D; Human Neuron Core, Rosamund Stone Zander Translational Neuroscience Center and F.M. Kirby Neurobiology Department, Boston Children's Hospital, Boston, MA, USA., Buttermore ED; Human Neuron Core, Rosamund Stone Zander Translational Neuroscience Center and F.M. Kirby Neurobiology Department, Boston Children's Hospital, Boston, MA, USA., Tartaglia GG; Center for Human Technologies (CHT), Istituto Italiano di Tecnologia (IIT), Genova, Italy., Lagarkova MA; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435, Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435, Moscow, Russia., Katanaev VL; School of Medicine and Life Sciences, Far Eastern Federal University, 690090, Vladivostok, Russia.; Department of Cell Physiology and Metabolism, Faculty of Medicine, Translational Research Center in Oncohaematology, University of Geneva, 1211, Geneva, Switzerland., Musayev I; Child's Cure Genetic Research, Fremont, CA, USA., Martinelli S; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy., Fucile S; Department of Physiology and Pharmacology 'V. Erspamer', Sapienza University of Rome, Rome, Italy.; IRCCS Neuromed, Pozzilli, Italy., Rosa A; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy.; Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), Rome, Italy.

Publikováno v: Heliyon [Heliyon] 2024 Feb 21; Vol. 10 (5), pp. e26656. Date of Electronic Publication: 2024 Feb 21 (Print Publication: 2024).

The activity of the Striatal-enriched protein tyrosine phosphatase in neuronal cells is modulated by adenosine A 2A receptor.

Autor: Mallozzi C; Department of Neuroscience, Istituto Superiore di Sanità, Rome, Italy., Pepponi R; National Centre for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy., Visentin S; National Centre for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy., Chiodi V; National Centre for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy., Lombroso PJ; Child Study Center, Yale School of Medicine, New Haven, CT, USA., Bader M; Max-Delbrűck-Center for Molecular Medicine, Berlin, Germany., Popoli P; National Centre for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy., Domenici MR; National Centre for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy.

Publikováno v: Journal of neurochemistry [J Neurochem] 2020 Feb; Vol. 152 (3), pp. 284-298. Date of Electronic Publication: 2019 Oct 10.

Fenretinide Beneficial Effects on Amyotrophic Lateral Sclerosis-associated SOD1 ^G93A Mutant Protein Toxicity: In Vitro and In Vivo Evidences.

Autor: Orienti I; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy., Armida M; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy., Dobrowolny G; DAHFMO-Unit of Histology and Medical Embryology, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy., Pepponi R; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy., Sollazzini G; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy., Pezzola A; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy., Casola I; DAHFMO-Unit of Histology and Medical Embryology, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy., Musarò A; DAHFMO-Unit of Histology and Medical Embryology, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy., Popoli P; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy., Potenza RL; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy. Electronic address: rosa.potenza@iss.it.

Publikováno v: Neuroscience [Neuroscience] 2021 Oct 01; Vol. 473, pp. 1-12. Date of Electronic Publication: 2021 Aug 05.

P2X7 Receptor Agonist 2'(3')-O-(4-Benzoylbenzoyl)ATP Differently Modulates Cell Viability and Corticostriatal Synaptic Transmission in Experimental Models of Huntington's Disease.

Autor: Martire A; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy., Pepponi R; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy., Liguori F; Preclinical Neuroscience, IRCCS Santa Lucia Foundation, Rome, Italy., Volonté C; Preclinical Neuroscience, IRCCS Santa Lucia Foundation, Rome, Italy.; Institute for Systems Analysis and Computer Science 'A. Ruberti', National Research Council (IASI-CNR), Rome, Italy., Popoli P; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2021 Feb 19; Vol. 11, pp. 633861. Date of Electronic Publication: 2021 Feb 19 (Print Publication: 2020).

Evidence of a possible Neuroprotective effect of Thymosin beta4 in experimental models of ecitotoxicity

Autor: Popoli P. 1, Pepponi R. 1, Martire A. 1, Tebano M.T. 1, Potenza R.L. 1, Domenici M.R. 1, Pintor A. 1, Armida A. 1, Mollinari C. 1, Merlo D. 1, 2, Garaci E. 3.

Publikováno v: First International Symposium on Thymosins in Health and Disease., Washington, USA, Dicembre, 2007
info:cnr-pdr/source/autori:Popoli P. 1, Pepponi R. 1, Martire A. 1, Tebano M.T. 1, Potenza R.L. 1, Domenici M.R. 1, Pintor A. 1, Armida A. 1, Mollinari C. 1, Merlo D. 1,2, Garaci E. 3./congresso_nome:First International Symposium on Thymosins in Health and Disease./congresso_luogo:Washington, USA/congresso_data:Dicembre, 2007/anno:2007/pagina_da:/pagina_a:/intervallo_pagine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::ef0a539d73a4edc4af770a131698c822
http://www.cnr.it/prodotto/i/224806