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A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration

Autor: De Luca G. 1, Russo M.T. 1, Degan P. 2, Tiveron C. 3, Zijno A. 1, Meccia E. 1, Ventura I. 1, Mattei E. 4, Nakabeppu Y. 5, Crescenzi M. 1, Pepponi R. 6, Pezzola A. 6, Popoli P. 6, Bignami M. 1.

Publikováno v: PLOS genetics 4(11) (2008): 1–14.
info:cnr-pdr/source/autori:De Luca G. 1#; Russo M.T. 1#; Degan P. 2; Tiveron C. 3; Zijno A. 1; Meccia E. 1; Ventura I. 1; Mattei E. 4; Nakabeppu Y. 5; Crescenzi M. 1; Pepponi R. 6; Pezzola A. 6; Popoli P. 6; Bignami M. 1./titolo:A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration/doi:/rivista:PLOS genetics/anno:2008/pagina_da:1/pagina_a:14/intervallo_pagine:1–14/volume:4(11)

Several human neurodegenerative disorders are characterized by the accumulation of 8-oxo-7,8-dihydroguanine (8-oxodG) in the DNA of affected neurons. This can occur either through direct oxidation of DNA guanine or via incorporation of the oxidized n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::6d32a7d77da287d3c8c40253faa14cf2
https://publications.cnr.it/doc/4888

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Evidence of a possible Neuroprotective effect of Thymosin beta4 in experimental models of ecitotoxicity

Autor: Popoli P. 1, Pepponi R. 1, Martire A. 1, Tebano M.T. 1, Potenza R.L. 1, Domenici M.R. 1, Pintor A. 1, Armida A. 1, Mollinari C. 1, Merlo D. 1, 2, Garaci E. 3.

Publikováno v: First International Symposium on Thymosins in Health and Disease., Washington, USA, Dicembre, 2007
info:cnr-pdr/source/autori:Popoli P. 1, Pepponi R. 1, Martire A. 1, Tebano M.T. 1, Potenza R.L. 1, Domenici M.R. 1, Pintor A. 1, Armida A. 1, Mollinari C. 1, Merlo D. 1,2, Garaci E. 3./congresso_nome:First International Symposium on Thymosins in Health and Disease./congresso_luogo:Washington, USA/congresso_data:Dicembre, 2007/anno:2007/pagina_da:/pagina_a:/intervallo_pagine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::ef0a539d73a4edc4af770a131698c822
http://www.cnr.it/prodotto/i/224806

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Combined effect of temozolomide and hyperthermia on human melanoma cell growth and O-6-methylguanine-DNA methyltransferase activity

Autor: Pagani, E, Falcinelli, S, Pepponi, R, Turriziani, M, Caporaso, P, Caporali, S, Bonmassar, E, D'Atri, S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3667::15e725f2cacd196a4a56e5c4aa7a7f65
http://hdl.handle.net/2108/49213

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A syngle cycle of treatment with temozolomide, alone or combined with O6-benzylguanine, induces strong chemoresistance in melanoma cell clones: role of o6-methylguanine-DNA methyltransferase and the mismatch repair system

Autor: ALVINO E(1), CASTIGLIA D(2), CAPORALI E(3), PEPPONI R(3, CAPORASO P(3), LACAL PM(3), MARRA G(4), FISCHER F(4), ZAMBRUNO G(2), BONMASSAR E(5), JIRICNY J(4), D'ATRI S(3).

Publikováno v: International journal of oncology 29 (2006): 785–797.
info:cnr-pdr/source/autori:ALVINO E(1),CASTIGLIA D(2), CAPORALI E(3), PEPPONI R(3,6), CAPORASO P(3), LACAL PM(3), MARRA G(4), FISCHER F(4), ZAMBRUNO G(2), BONMASSAR E(5), JIRICNY J(4), D'ATRI S(3)./titolo:A syngle cycle of treatment with temozolomide, alone or combined with O6-benzylguanine, induces strong chemoresistance in melanoma cell clones: role of o6-methylguanine-DNA methyltransferase and the mismatch repair system./doi:/rivista:International journal of oncology/anno:2006/pagina_da:785/pagina_a:797/intervallo_pagine:785–797/volume:29

Clinically achievable concentrations of temozolomide (TMZ) produce cytotoxic effects only in mismatch repair (MMR)-proficient cells endowed with low O6-methylguanine-DNA methyltransferase (MGMT) activity. Aim of the present study was to investigate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::b16b36a8f7c54ee93f2cceb2bf29bf6e
http://www.cnr.it/prodotto/i/4697

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The effect of O6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1,3-bis(2-chloroethyl)1-nitrosourea, and cisplatin

Autor: Pepponi, R, Marra, Giancarlo, Fuggetta, M P, Falcinelli, S, Pagani, E, Bonmassar, E, Jiricny, J, D'Atri, S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______885::a4cf0e3cddf20f65230862cd05ea2aca
https://www.zora.uzh.ch/id/eprint/31252/

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The effect of O6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells

Autor: Pepponi R., Marra G., Fuggetta M.P., Falcinelli S., Pagani E., Bonmassar E., Jiricny J., D'Atri S.

Publikováno v: 304 (2003): 661–668.
info:cnr-pdr/source/autori:Pepponi R., Marra G., Fuggetta M.P., Falcinelli S., Pagani E., Bonmassar E., Jiricny J., D'Atri S./titolo:The effect of O6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells/doi:/rivista:/anno:2003/pagina_da:661/pagina_a:668/intervallo_pagine:661–668/volume:304

The prognosis of advanced melanoma is generally poor, because this tumor commonly exhibits intrinsic or acquired resistance to chemotherapy. In an attempt to identify the underlying causes of this resistance, we studied the roles played by the DNA re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::d5eac47d62fa77ab91742ba43b82d857
https://publications.cnr.it/doc/4539

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