Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Pepper Dawes"'
Autor:
Salome Funes, Jonathan Jung, Del Hayden Gadd, Michelle Mosqueda, Jianjun Zhong, Shankaracharya, Matthew Unger, Karly Stallworth, Debra Cameron, Melissa S. Rotunno, Pepper Dawes, Megan Fowler-Magaw, Pamela J. Keagle, Justin A. McDonough, Sivakumar Boopathy, Miguel Sena-Esteves, Jeffrey A. Nickerson, Cathleen Lutz, William C. Skarnes, Elaine T. Lim, Dorothy P. Schafer, Francesca Massi, John E. Landers, Daryl A. Bosco
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Microglia play a pivotal role in neurodegenerative disease pathogenesis, but the mechanisms underlying microglia dysfunction and toxicity remain to be elucidated. To investigate the effect of neurodegenerative disease-linked genes on the int
Externí odkaz:
https://doaj.org/article/2c85d3969eb543aa96ee0dead9833143
Autor:
Molly Smullen, Meagan N. Olson, Liam F. Murray, Madhusoodhanan Suresh, Guang Yan, Pepper Dawes, Nathaniel J. Barton, Jivanna N. Mason, Yucheng Zhang, Aria A. Fernandez-Fontaine, George M. Church, Diego Mastroeni, Qi Wang, Elaine T. Lim, Yingleong Chan, Benjamin Readhead
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Mitochondrial (MT) dysfunction has been associated with several neurodegenerative diseases including Alzheimer’s disease (AD). While MT-copy number differences have been implicated in AD, the effect of MT heteroplasmy on AD has not been we
Externí odkaz:
https://doaj.org/article/7f133d69551245a7bf77cd609ed77e08
Autor:
Elaine T. Lim, Yingleong Chan, Pepper Dawes, Xiaoge Guo, Serkan Erdin, Derek J. C. Tai, Songlei Liu, Julia M. Reichert, Mannix J. Burns, Ying Kai Chan, Jessica J. Chiang, Katharina Meyer, Xiaochang Zhang, Christopher A. Walsh, Bruce A. Yankner, Soumya Raychaudhuri, Joel N. Hirschhorn, James F. Gusella, Michael E. Talkowski, George M. Church
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Cerebral organoids can be used to gain insights into neuropsychiatric disorders. Here the authors carry out RNAseq characterization from organoids derived from donors with autism spectrum disorder to identify associated cell type specific driver gene
Externí odkaz:
https://doaj.org/article/95de5f4e0e584e9ba9efd47fbab020ce
Autor:
Pepper Dawes, Liam F. Murray, Meagan N. Olson, Nathaniel J. Barton, Molly Smullen, Madhusoodhanan Suresh, Guang Yan, Yucheng Zhang, Aria Fernandez-Fontaine, Jay English, Mohammed Uddin, ChangHui Pak, George M. Church, Yingleong Chan, Elaine T. Lim
Publikováno v:
Human Genetics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e338a2b1ae745e7881339897d705ba20
https://doi.org/10.1007/s00439-023-02534-4
https://doi.org/10.1007/s00439-023-02534-4
Autor:
Pepper Dawes, Molly Smullen, Aria Fernandez-Fontaine, Yucheng Zhang, Jay English, Mohammed Uddin, ChangHui Pak, George M Church, Yingleong Chan, Elaine T Lim
Cerebral organoids are comprised of diverse cell types found in the developing human brain, and can be leveraged for the identification of critical cell types perturbed by genetic risk variants in common, neuropsychiatric disorders. There is great in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51d395f8317bb3cbc91b66546359ec82
https://doi.org/10.21203/rs.3.rs-1825493/v1
https://doi.org/10.21203/rs.3.rs-1825493/v1
Autor:
Molly Smullen, Julia M Reichert, Pepper Dawes, Qi Wang, Benjamin Readhead, George M Church, Elaine T Lim, Yingleong Chan
Publikováno v:
SSRN Electronic Journal.
Inducing somatic cells into pluripotent stem cells (iPSCs) provides an excellent model for studying systems in-vitro. Understanding the impact of individual donor genetic backgrounds on reprogramming ability would allow researchers to harness these g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4239f4086b0ba9f5a8821781c284a8f8
https://doi.org/10.2139/ssrn.4156844
https://doi.org/10.2139/ssrn.4156844