Zobrazeno 1 - 10
of 41 651
pro vyhledávání: '"Pepper"'
Autor:
Sushil Kumar, Dhanir Tailor, Arpit Dheeraj, Wenqi Li, Kirsten Stefan, Jee Min Lee, Dylan Nelson, Bailey F. Keefe, Pepper Schedin, Shivaani Kummar, Lisa M. Coussens, Sanjay V. Malhotra
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101698- (2024)
Summary: Tumor-associated macrophages (TAMs) and other myelomonocytic cells are implicated in regulating responsiveness to immunotherapies, including immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis. We have developed an ex vivo high
Externí odkaz:
https://doaj.org/article/cfaf32627f2d4969978c0e42493daa35
Autor:
Salome Funes, Jonathan Jung, Del Hayden Gadd, Michelle Mosqueda, Jianjun Zhong, Shankaracharya, Matthew Unger, Karly Stallworth, Debra Cameron, Melissa S. Rotunno, Pepper Dawes, Megan Fowler-Magaw, Pamela J. Keagle, Justin A. McDonough, Sivakumar Boopathy, Miguel Sena-Esteves, Jeffrey A. Nickerson, Cathleen Lutz, William C. Skarnes, Elaine T. Lim, Dorothy P. Schafer, Francesca Massi, John E. Landers, Daryl A. Bosco
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Microglia play a pivotal role in neurodegenerative disease pathogenesis, but the mechanisms underlying microglia dysfunction and toxicity remain to be elucidated. To investigate the effect of neurodegenerative disease-linked genes on the int
Externí odkaz:
https://doaj.org/article/2c85d3969eb543aa96ee0dead9833143
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Young onset breast cancer (YOBC) is an increasing demographic with unique biology, limited screening, and poor outcomes. Further, women with postpartum breast cancers (PPBCs), cancers occurring up to 10 years after childbirth, have worse outcomes tha
Externí odkaz:
https://doaj.org/article/2c2718154c984f949bf627fef385d493
Autor:
Molly Smullen, Meagan N. Olson, Liam F. Murray, Madhusoodhanan Suresh, Guang Yan, Pepper Dawes, Nathaniel J. Barton, Jivanna N. Mason, Yucheng Zhang, Aria A. Fernandez-Fontaine, George M. Church, Diego Mastroeni, Qi Wang, Elaine T. Lim, Yingleong Chan, Benjamin Readhead
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Mitochondrial (MT) dysfunction has been associated with several neurodegenerative diseases including Alzheimer’s disease (AD). While MT-copy number differences have been implicated in AD, the effect of MT heteroplasmy on AD has not been we
Externí odkaz:
https://doaj.org/article/7f133d69551245a7bf77cd609ed77e08
Autor:
Lusine Yaghjyan, A. Heather Eliassen, Graham Colditz, Bernard Rosner, Pepper Schedin, Akemi Wijayabahu, Rulla M. Tamimi
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-8 (2022)
Abstract Background We investigated the associations of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) with breast cancer risk by the status of COX-2 protein expression. Methods This study included 421 cases and 3,166 controls from a
Externí odkaz:
https://doaj.org/article/cf40428cf8534c0c9d0392e4f5f56e55
Publikováno v:
Discussiones Mathematicae Graph Theory, Vol 42, Iss 3, Pp 921-935 (2022)
In this paper we study relationships between the matching number, written µ(G), and the independence number, written α(G). Our first main result is to show
Externí odkaz:
https://doaj.org/article/43f47dc1c919410a8252c54bfaed9cd6
Autor:
Elizabeth A. Wellberg, Karen A. Corleto, L. Allyson Checkley, Sonali Jindal, Ginger Johnson, Janine A. Higgins, Sarina Obeid, Steven M. Anderson, Ann D. Thor, Pepper J. Schedin, Paul S. MacLean, Erin D. Giles
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-13 (2022)
Abstract Background Obesity and adult weight gain are linked to increased breast cancer risk and poorer clinical outcomes in postmenopausal women, particularly for hormone-dependent tumors. Menopause is a time when significant weight gain occurs in m
Externí odkaz:
https://doaj.org/article/fe059f40f7664debab0869772fb8b494
Autor:
Elaine T. Lim, Yingleong Chan, Pepper Dawes, Xiaoge Guo, Serkan Erdin, Derek J. C. Tai, Songlei Liu, Julia M. Reichert, Mannix J. Burns, Ying Kai Chan, Jessica J. Chiang, Katharina Meyer, Xiaochang Zhang, Christopher A. Walsh, Bruce A. Yankner, Soumya Raychaudhuri, Joel N. Hirschhorn, James F. Gusella, Michael E. Talkowski, George M. Church
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Cerebral organoids can be used to gain insights into neuropsychiatric disorders. Here the authors carry out RNAseq characterization from organoids derived from donors with autism spectrum disorder to identify associated cell type specific driver gene
Externí odkaz:
https://doaj.org/article/95de5f4e0e584e9ba9efd47fbab020ce
Autor:
Kilcoyne A, Jordan E, Thomas K, Pepper AN, Zhou A, Chappell D, Amarapala M, Thériault RK, Thompson M
Publikováno v:
ClinicoEconomics and Outcomes Research, Vol Volume 14, Pp 231-247 (2022)
Adrian Kilcoyne,1 Edward Jordan,1 Kimberly Thomas,2 Alicia N Pepper,2 Allen Zhou,2 Dale Chappell,1 Miyuru Amarapala,1 Rachel-Karson Thériault,2 Melissa Thompson2 1HEOR, Humanigen Inc, Burlingame, CA, USA; 2Value & Evidence Services, EVERSANA, Burlin
Externí odkaz:
https://doaj.org/article/700c660904a64c54b2b938ddcc8e0199
Autor:
Sonali Jindal, Nathan D. Pennock, Duanchen Sun, Wesley Horton, Michelle K. Ozaki, Jayasri Narasimhan, Alexandra Q. Bartlett, Sheila Weinmann, Paul E. Goss, Virginia F. Borges, Zheng Xia, Pepper Schedin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The molecular differences between postpartum (PPBC) and nulliparous (NPBC) young women breast cancer (YWBC) patients remain unknown. Here the authors perform RNA sequencing and multiplex immunohistochemistry on an FFPE breast cancer cohort and sugges
Externí odkaz:
https://doaj.org/article/0e10b40c44fd4f99a9a9f2ec3a3bf0dd