A d-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of Mycobacterium tuberculosis .

Autor: Pepi MJ; Graduate Program in Chemistry, Brandeis University, Waltham 02453, Massachusetts, United States., Chacko S; Department of Biology, Brandeis University, Waltham 02453, Massachusetts, United States., Marqus GM; Graduate Program in Chemistry, Brandeis University, Waltham 02453, Massachusetts, United States., Singh V; Drug Discovery and Development Centre (H3D), and South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa., Wang Z; Division of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York 10065, New York, United States., Planck K; Division of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York 10065, New York, United States., Cullinane RT; Department of Biology, Brandeis University, Waltham 02453, Massachusetts, United States., Meka PN; Department of Biology, Brandeis University, Waltham 02453, Massachusetts, United States., Gollapalli DR; Department of Biology, Brandeis University, Waltham 02453, Massachusetts, United States., Ioerger TR; Department of Computer Science and Engineering, Texas A&M University, College Station 77843, Texas, United States., Rhee KY; Division of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York 10065, New York, United States., Cuny GD; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston 77204, Texas, United States., Boshoff HIM; Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, Bethesda 20892, Maryland, United States., Hedstrom L; Department of Biology, Brandeis University, Waltham 02453, Massachusetts, United States.; Department of Chemistry, Brandeis University, Waltham 02453, Massachusetts, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2022 Feb 11; Vol. 8 (2), pp. 330-342. Date of Electronic Publication: 2022 Jan 11.

Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents.

Autor: Chacko S, Boshoff HIM; Tuberculosis Research Section , National Institute of Allergy and Infectious Diseases , Bethesda , Maryland 20892 , United States., Singh V; Department of Drug Discovery and Development & Institute of Infectious Disease and Molecular Medicine , H3D Drug Discovery and Development Centre, University of Cape Town , Rondebosch , Cape Town 7701 , South Africa., Ferraris DM; Dipartimento di Scienze del Farmaco , Universitá del Piemonte Orientale , Via Bovio 6 , 28100 Novara , Italy., Gollapalli DR, Zhang M, Lawson AP, Pepi MJ, Joachimiak A; Center for Structural Genomics of Infectious Diseases and Department of Biochemistry and Molecular Biology , University of Chicago , Chicago , Illinois 60557 , United States.; Structural Biology Center, Biosciences , Argonne National Laboratory , 9700 S. Cass Avenue, Argonne , Illinois 60439 , United States., Rizzi M; Dipartimento di Scienze del Farmaco , Universitá del Piemonte Orientale , Via Bovio 6 , 28100 Novara , Italy., Mizrahi V; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine & Department of Pathology , University of Cape Town , Anzio Road , Observatory 7925 , South Africa., Cuny GD; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy , University of Houston , Health Building 2, 4849 Calhoun Road , Houston , Texas 77204 , United States., Hedstrom L

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Jun 14; Vol. 61 (11), pp. 4739-4756. Date of Electronic Publication: 2018 May 30.