Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan.

Autor: Kakraba S; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Ayyadevara S; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; Central Arkansas Veterans Healthcare Service, Little Rock, AR 72205, USA., Mainali N; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Balasubramaniam M; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Bowroju S; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Penthala NR; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Atluri R; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Barger SW; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; Central Arkansas Veterans Healthcare Service, Little Rock, AR 72205, USA., Griffin ST; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; Central Arkansas Veterans Healthcare Service, Little Rock, AR 72205, USA., Crooks PA; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Shmookler Reis RJ; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; Central Arkansas Veterans Healthcare Service, Little Rock, AR 72205, USA.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2023 Oct 20; Vol. 16 (10). Date of Electronic Publication: 2023 Oct 20.

Biobanked Glioblastoma Patient-Derived Organoids as a Precision Medicine Model to Study Inhibition of Invasion.

Autor: Darrigues E; Department of Neurosurgery, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Zhao EH; Department of Neurosurgery, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., De Loose A; Department of Neurosurgery, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Lee MP; Department of Neurosurgery, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Borrelli MJ; Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Eoff RL; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Galileo DS; Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA., Penthala NR; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Crooks PA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Rodriguez A; Department of Neurosurgery, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Oct 03; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 03.

A pharmacokinetic study of morphine-6-O-sulfate in rat plasma and brain.

Autor: Yadlapalli JSK; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Albayati ZAF; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Breen PJ; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Dobretsov M; Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Neurobiology and Developmental Neuroscience, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Penthala NR; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Hendrickson HP; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Crooks PA; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Publikováno v: Drug development research [Drug Dev Res] 2021 Sep; Vol. 82 (6), pp. 802-814. Date of Electronic Publication: 2021 Jan 11.

Aging-associated skeletal muscle defects in HER2/Neu transgenic mammary tumor model.

Autor: Wang R; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Kumar B; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Bhat-Nakshatri P; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Prasad MS; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Jacobsen MH; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Ovalle G; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Maguire C; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Sandusky G; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Trivedi T; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Mohammad KS; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Guise T; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Penthala NR; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Crooks PA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Liu J; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Zimmers T; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA., Nakshatri H; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA.

Publikováno v: JCSM rapid communications [JCSM Rapid Commun] 2021 Jan-Jun; Vol. 4 (1), pp. 24-39. Date of Electronic Publication: 2020 Jul 15.

Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs.

Autor: Balasubramaniam M; McClellan Veterans Medical Ctr., Central Arkansas Veterans Healthcare Service, Little Rock, AR, 72205, USA. mbalasubramaniam@uams.edu.; Department of Geriatrics, Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA. mbalasubramaniam@uams.edu., Mainali N; Bioinformatics Program, University of Arkansas for Medical Sciences, and University of Arkansas At Little Rock, Little Rock, AR, 72205, USA., Bowroju SK; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA., Atluri P; Summer Research Internship Program, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA., Penthala NR; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA., Ayyadevera S; McClellan Veterans Medical Ctr., Central Arkansas Veterans Healthcare Service, Little Rock, AR, 72205, USA.; Department of Geriatrics, Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA., Crooks PA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA., Shmookler Reis RJ; McClellan Veterans Medical Ctr., Central Arkansas Veterans Healthcare Service, Little Rock, AR, 72205, USA. rjsr@uams.edu.; Department of Geriatrics, Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA. rjsr@uams.edu.

Publikováno v: Scientific reports [Sci Rep] 2020 Oct 27; Vol. 10 (1), pp. 18326. Date of Electronic Publication: 2020 Oct 27.