Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models.

Autor: Toledo-Sherman L; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Breccia P; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Cachope R; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Bate JR; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Angulo-Herrera I; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Wishart G; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Matthews KL; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Martin SL; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Cox HC; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., McAllister G; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Penrose SD; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Vater H; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Esmieu W; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Van de Poël A; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Van de Bospoort R; Charles River , Leiden 2333 CR , Netherlands., Strijbosch A; Charles River , Leiden 2333 CR , Netherlands., Lamers M; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Leonard P; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Jarvis RE; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Blackaby W; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Barnes K; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Eznarriaga M; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Dowler S; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Smith GD; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Fischer DF; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Lazari O; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Yates D; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Rose M; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Jang SW; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Muñoz-Sanjuan I; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Dominguez C; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 Mar 28; Vol. 62 (6), pp. 2988-3008. Date of Electronic Publication: 2019 Mar 19.

Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease.

Autor: Bürli RW; BioFocus , Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Luckhurst CA, Aziz O, Matthews KL, Yates D, Lyons KA, Beconi M, McAllister G, Breccia P, Stott AJ, Penrose SD, Wall M, Lamers M, Leonard P, Müller I, Richardson CM, Jarvis R, Stones L, Hughes S, Wishart G, Haughan AF, O'Connell C, Mead T, McNeil H, Vann J, Mangette J, Maillard M, Beaumont V, Munoz-Sanjuan I, Dominguez C

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2013 Dec 27; Vol. 56 (24), pp. 9934-54. Date of Electronic Publication: 2013 Dec 05.

Rhodium catalysed conjugate addition of a chiral alkenyltrifluoroborate salt: the enantioselective synthesis of hermitamides A and B.

Autor: Frost CG; Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK. c.g.frost@bath.ac.uk, Penrose SD, Gleave R

Publikováno v: Organic & biomolecular chemistry [Org Biomol Chem] 2008 Dec 07; Vol. 6 (23), pp. 4340-7. Date of Electronic Publication: 2008 Oct 18.