Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Penny Zhu"'
Autor:
Namphuong Tran, Honghui Zhou, Brendan M. Weiss, Peijuan Penny Zhu, Man Melody Luo, Xiang Qin, Raymond L. Comenzo, Jessica Vermeulen, Amarnath Sharma, Ivo Nnane, Ashutosh D. Wechalekar, Yuan Xiong, Efstathios Kastritis, Giampaolo Merlini, Yu-Nien Sun
Publikováno v:
Journal of clinical pharmacologyReferences. 62(5)
The purpose of this study is to characterize the population pharmacokinetics (PopPK) of subcutaneous (SC) daratumumab in combination with bortezomib, cyclophosphamide, and dexamethasone and explore the relationship between daratumumab systemic exposu
Autor:
Guillaume Baneyx, William M. Sallas, Hequn Yin, Neva Coello, Jerry Nedelman, Penny Zhu, Francois Pierre Combes
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 45:707-719
Everolimus is approved in Europe and in the USA for the adjunctive treatment of patients aged 2 years and older whose refractory partial-onset seizures, with or without secondary generalization, are associated with tuberous sclerosis complex. The obj
Autor:
Hongwei Qi, James F. Callahan, Brian Peck, Catherine Booth-Genthe, Edit Kurali, Wensheng Xie, Sharon Sweitzer, Joseph P. Marino, Stephanie Chen, Chad Quinn, Benjamin Schwartz, David J. Behm, Ruth J. Mayer, Svetlana L. Belyanskaya, Marc Galop, Brian Bolognese, Barry A. Morgan, Patricia L. Podolin, Mary S. Barnette, Yun Ding, Sandra Umbrecht, Xiaojun Zhang, Joseph F. Foley, David I. Israel, Edward Long, Penny Zhu
Publikováno v:
Prostaglandins & Other Lipid Mediators. :25-31
Soluble epoxide hydrolase (sEH, EPHX2) metabolizes eicosanoid epoxides, including epoxyeicosatrienoic acids (EETs) to the corresponding dihydroxyeicosatrienoic acids (DHETs), and leukotoxin (LTX) to leukotoxin diol (LTX diol). EETs, endothelium-deriv
Publikováno v:
Journal of Chromatography B. 879:2487-2493
Substrates and products of soluble epoxide hydrolase (sEH) such as 14,15-epoxyeicosatrienoic acid (14,15-EET), 14,15-dihydroxyeicosatrienoic acid (14,15-DHET), leukotoxin, and leukotoxin diol are potential biomarkers for assessing sEH activity in cli
Autor:
Sandra Postel, David M. Kranz, Eric J. Sundberg, Daniel A. Bonsor, Zhiping Weng, Ningyan Wang, Brian G. Pierce, Rebecca A. Buonpane, Penny Zhu
Publikováno v:
Journal of Molecular Biology. 411:321-328
Protein engineering is becoming increasingly important for pharmaceutical applications where controlling the specificity and affinity of engineered proteins is required to create targeted protein therapeutics. Affinity increases of several thousand-f
Autor:
John K. McCormick, Christine A. Herfst, Rebecca A. Buonpane, A. K. M. Nur-ur Rahman, Beenu Moza, Penny Zhu, Eric J. Sundberg, David M. Kranz
Publikováno v:
Proceedings of the National Academy of Sciences. 103:9867-9872
Although cellular processes depend on protein–protein interactions, our understanding of molecular recognition between proteins remains far from comprehensive. Protein–protein interfaces are structural and energetic mosaics in which a subset of i
Autor:
Christopher Leo, Martha Rook, Manjit Kaur, Penny Zhu, Elizabeth A. Maher, Cameron Brennan, Lynda Chin, Jia Liu Wolfe, G. Mike Makrigiorgos, Gang Wang
Publikováno v:
Genome Research. 14:2357-2366
Despite recent advances in linear whole genome amplification of intact DNA/RNA, amplification of degraded nucleic acids in an unbiased fashion remains a serious challenge for genetic diagnosis. We describe a new whole genome amplification procedure,
Autor:
A. K. M. Nur-ur Rahman, John K. McCormick, Penny Zhu, Ashok K. Varma, Aaron W. Wyatt, Beenu Moza, Roy A. Mariuzza, Katherine J. Kasper, Yili Li, Sebastian Günther, Eric J. Sundberg
Superantigens (SAGs) interact with host immune receptors to induce a massive release of inflammatory cytokines that can lead to toxic shock syndrome and death. Bacterial SAGs can be classified into five distinct evolutionary groups. Group V SAGs are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca911c3ecead0dd67c994d577b3b375f
https://europepmc.org/articles/PMC2949350/
https://europepmc.org/articles/PMC2949350/
Autor:
Beenu Moza, John K. McCormick, Penny Zhu, Christine A. Herfst, David M. Kranz, Anne Kathrin Wilbuer, Rebecca A. Buonpane, Kai W. Wucherpfennig, Eric J. Sundberg, Nilufer P. Seth, Melissa J. Nicholson, Ashok K. Varma
Publikováno v:
The EMBO journal. 26(4)
Superantigens (SAGs) bind simultaneously to major histocompatibility complex (MHC) and T-cell receptor (TCR) molecules, resulting in the massive release of inflammatory cytokines that can lead to toxic shock syndrome (TSS) and death. A major causativ
Publikováno v:
Clinical chemistry and laboratory medicine. 43(8)
Large numbers of mutations are postulated to occur as early events in carcinogenesis. For certain types of human tumors (mutator phenotypes) these mutations can be a driving force in generating clonogenic, causative genetic changes leading to multist