Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Penny L, Groves"'
1
Akademický článek
Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8+ T Cell Responses but Differ in Capacity to Induce CD4+ T Cell Responses and Antibody Responses
Autor: David J. Pattinson, Simon H. Apte, Nani Wibowo, Tania Rivera-Hernandez, Penny L. Groves, Anton P. J. Middelberg, Denise L. Doolan
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Despite extensive research, the development of an effective malaria vaccine remains elusive. The induction of robust and sustained T cell and antibody response by vaccination is an urgent unmet need. Chimeric virus-like particles (VLPs) are a promisi
Externí odkaz: https://doaj.org/article/0d170ccf359b4ae9a6c7c4cb5d45785b
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2
Akademický článek
Chimeric Murine Polyomavirus Virus-Like Particles Induce Plasmodium Antigen-Specific CD8+ T Cell and Antibody Responses
Autor: David J. Pattinson, Simon H. Apte, Nani Wibowo, Yap P. Chuan, Tania Rivera-Hernandez, Penny L. Groves, Linda H. Lua, Anton P. J. Middelberg, Denise L. Doolan
Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
An effective vaccine against the Plasmodium parasite is likely to require the induction of robust antibody and T cell responses. Chimeric virus-like particles are an effective vaccine platform for induction of antibody responses, but their capacity t
Externí odkaz: https://doaj.org/article/2ab14d53e54c407b842d77fdd23cdede
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3
Akademický článek
Reduced Plasmodium Parasite Burden Associates with CD38+ CD4+ T Cells Displaying Cytolytic Potential and Impaired IFN-γ Production.
Autor: Julie G Burel, Simon H Apte, Penny L Groves, Kerenaftali Klein, James S McCarthy, Denise L Doolan
Publikováno v: PLoS Pathogens, Vol 12, Iss 9, p e1005839 (2016)
Using a unique resource of samples from a controlled human malaria infection (CHMI) study, we identified a novel population of CD4+ T cells whose frequency in the peripheral blood was inversely correlated with parasite burden following P. falciparum
Externí odkaz: https://doaj.org/article/6863119f7e5b41faa8f185cfd33839e3
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5
Akademický článek
Highly sensitive quantitative real-time PCR for the detection of Plasmodium liver-stage parasite burden following low-dose sporozoite challenge.
Autor: Sophie Schussek, Penny L Groves, Simon H Apte, Denise L Doolan
Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77811 (2013)
The pre-erythrocytic stages of Plasmodium spp. are increasingly recognised as ideal targets for prophylactic vaccines and drug treatments. Intense research efforts in the last decade have been focused on in vitro culture and in vivo detection and qua
Externí odkaz: https://doaj.org/article/adc9ae7a46ac4e53b4a7b0ef11d3354b
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6
Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8+ T Cell Responses but Differ in Capacity to Induce CD4+ T Cell Responses and Antibody Responses
Autor: Simon H. Apte, David J. Pattinson, Penny L. Groves, Anton P. J. Middelberg, Denise L. Doolan, Tania Rivera-Hernandez, Nani Wibowo
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Despite extensive research, the development of an effective malaria vaccine remains elusive. The induction of robust and sustained T cell and antibody response by vaccination is an urgent unmet need. Chimeric virus-like particles (VLPs) are a promisi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0444f14a415af94aec3af03e1199cf30
https://www.frontiersin.org/article/10.3389/fimmu.2020.564627/full
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7
A population of CD4
Autor: Simon H, Apte, Gabriela, Minigo, Penny L, Groves, Jessie C, Spargo, Magdalena, Plebanski, Mathew J, Grigg, Enny, Kenangalem, Julie G, Burel, Jessica R, Loughland, Katie L, Flanagan, Kim A, Piera, Timothy, William, Ric N, Price, Tonia, Woodberry, Bridget E, Barber, Nicholas M, Anstey, Denise L, Doolan
Publikováno v: Clinical & Translational Immunology
Objective CD4+ T cells are critical mediators of immunity to Plasmodium spp. infection, but their characteristics during malarial episodes and immunopathology in naturally infected adults are poorly defined. Flow cytometric analysis of PBMCs from pat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6e468ad774d443bdf7bf89a91e141eee
https://pubmed.ncbi.nlm.nih.gov/33282291
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8
Akademický článek
Vaccination with lipid core peptides fails to induce epitope-specific T cell responses but confers non-specific protective immunity in a malaria model.
Autor: Simon H Apte, Penny L Groves, Mariusz Skwarczynski, Yoshio Fujita, Chenghung Chang, Istvan Toth, Denise L Doolan
Publikováno v: PLoS ONE, Vol 7, Iss 8, p e40928 (2012)
Vaccines against many pathogens for which conventional approaches have failed remain an unmet public health priority. Synthetic peptide-based vaccines offer an attractive alternative to whole protein and whole organism vaccines, particularly for comp
Externí odkaz: https://doaj.org/article/0659628ac1f34a1c95ab2a75a4fdc082
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9
Chemically Attenuated Blood-Stage Plasmodium yoelii Parasites Induce Long-Lived and Strain-Transcending Protection
Autor: Penny L. Groves, Virginia McPhun, Sumana Chakravarty, Denise L. Doolan, Amber I. Raja, Michael F. Good, Yeping Cai, Stephen L. Hoffman, Jennifer M. Reiman, Ian A. Cockburn, Danielle I. Stanisic
Publikováno v: Infection and Immunity
The development of a vaccine is essential for the elimination of malaria. However, despite many years of effort, a successful vaccine has not been achieved. Most subunit vaccine candidates tested in clinical trials have provided limited efficacy, and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992eaf3b7986839e1dd5d9565563b305
http://europepmc.org/articles/PMC4962623
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10
A balanced pro-inflammatory and regulatory cytokine signature in young African children is associated with lower risk of clinical malaria
Autor: Rebeca Santano, Tamara Katherine Berthoud, Alfons Jiménez, Llorenç Quintó, Caterina Guinovart, Pedro L. Alonso, Maria N. Manaca, John J. Aponte, Ruth Aguilar, Arnoldo Barbosa, Carlota Dobaño, Denise L. Doolan, Penny L Groves, Quique Bassat, Augusto Nhabomba, Mauricio H. Rodríguez
Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Clin Infect Dis
Background The effect of timing of exposure to first Plasmodium falciparum infections during early childhood on the induction of innate and adaptive cytokine responses and their contribution to the development of clinical malaria immunity is not well
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fffa4888dce168ace581808079dce8f4
http://hdl.handle.net/2445/128982
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