Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Penny E. Phillips"'
Autor:
Michael Sabio, Penny E. Phillips, Kenneth R. LaMontagne, Richard William Versace, Sunkyu Kim, Naeem Yusuff, Sushil K. Sharma
Publikováno v:
Cancer Research. 64:2984-2987
Inhibition of endothelial cell growth by fumagillin has been assumed to be mediated by inhibition of the molecular target methionine aminopeptidase 2 (MetAp2). New data show that depletion of MetAp2 by siRNA does not inhibit endothelial cell growth.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b8bdafef1808cbe48d3230c0f5be7b
https://doi.org/10.1158/0008-5472.can-04-0019
https://doi.org/10.1158/0008-5472.can-04-0019
Autor:
Patrick Schindler, Anthony A. Morollo, Richard William Versace, Hans Voshol, Penny E. Phillips, Hyun Kyu Song, Frederick Ray Kinder, Kenneth W. Bair, James A. DeCaprio, Sunkyu Kim, Jeanette Marjorie Wood, Sonya Zabludoff, Michael J. Eck, Harry Towbin, Dieter Mueller, Jan van Oostrum
Publikováno v:
Journal of Biological Chemistry. 278:52964-52971
LAF389 is a synthetic analogue of bengamides, a class of marine natural products that produce inhibitory effects on tumor growth in vitro and in vivo. A proteomics-based approach has been used to identify signaling pathways affected by bengamides. LA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc2177d41b19ffd4f676f4359e5325d9
https://doi.org/10.1074/jbc.m309039200
https://doi.org/10.1074/jbc.m309039200
Autor:
John Bontempo, Jagoe Christopher Turchik, Yin Mou, Ania M. Czuchta, Penny E. Phillips, Kenneth W. Bair, Frederick Ray Kinder, Long D. Tran, Sonya Zabludoff, Steven Chen, Run-Ming Wang, David Cesarz, Raphael Nemzek, Richard William Versace, Susan Weltchek, Phillip Crews
Publikováno v:
Journal of Medicinal Chemistry. 44:3692-3699
Bengamide B, a novel sponge-derived marine natural product with broad spectrum antitumor activity, was not suitable for further preclinical development because of its difficult synthesis and very poor water solubility. Bengamide B produced a 31% T/C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17234048bcbfe0dae8659e5596f5dcde
https://doi.org/10.1021/jm010188c
https://doi.org/10.1021/jm010188c
Autor:
Yansong J. Lu, John Bontempo, Frederick Ray Kinder, Sonya Zabludoff, H. Rao Marepalli, Liladhar Murlidhar Waykole, Run-Ming Wang, and David D. Xu, Sompong Wattanasin, Richard William Versace, Kenneth W. Bair, Penny E. Phillips, Long D. Tran, Didier Roche, Green Michael A
Publikováno v:
The Journal of Organic Chemistry. 66:2118-2122
Total syntheses of the cytotoxic marine natural products bengamides B and E are described. Both bengamides are prepared via amide coupling of a protected polyhydroxylated lactone intermediate 9 with a suitably substituted aminocaprolactam intermediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fc9ec261da2078cc8e3f74191a7410
https://doi.org/10.1021/jo0017133
https://doi.org/10.1021/jo0017133
Autor:
Zia Thale, Ania M. Czuchta, Penny E. Phillips, Miranda L. Sanders, Sompong Wattanasin, Richard William Versace, John Bontempo, Kinder Frederick Ray, Kenneth W. Bair, Phillip Crews
Publikováno v:
The Journal of Organic Chemistry. 66:1733-1741
The structural chemistry and biological activity of the bengamide class of compounds have been further characterized. Extracts prepared from recollected Jaspis cf. coriacea from five sites in Fiji were pooled. Six new bengamides, M (7b), N (8a), O (8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::014307d987e9a66d052328bc0def7d79
https://doi.org/10.1021/jo001380+
https://doi.org/10.1021/jo001380+
Autor:
Kenneth W. Bair, Miranda L. Sanders, Phillip Crews, Zia Thale, Kinder Frederick Ray, Sompong Wattanasin, Richard William Versace, Ania M. Czuchta, Penny E. Phillips, John Bontempo
Publikováno v:
ChemInform. 32
The structural chemistry and biological activity of the bengamide class of compounds have been further characterized. Extracts prepared from recollected Jaspis cf. coriacea from five sites in Fiji were pooled. Six new bengamides, M (7b), N (8a), O (8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ce6f262bad4db7d930b607bc848f515
https://doi.org/10.1002/chin.200126231
https://doi.org/10.1002/chin.200126231
Autor:
N R Nirmala, A Vattay, Penny E. Phillips, U Bhatia, B Wang, M Cueto, M Leszczyniecka, Sonya Zabludoff, Harry Towbin
Publikováno v:
Oncogene. 25(24)
N-terminal methionine removal is an important cellular process required for proper biological activity, subcellular localization, and eventual degradation of many proteins. The enzymes that catalyze this reaction are called Methionine Aminopeptidases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1164fbab3b670ea548264a29dadafd
https://pubmed.ncbi.nlm.nih.gov/16568094
https://pubmed.ncbi.nlm.nih.gov/16568094
Publikováno v:
Endothelin ISBN: 9781461475149
Endothelin, a potent vasoconstrictor peptide characterized by two intrachain disulfide bonds, was isolated from the cell culture media of porcine aortic endothelial cells,96 a rich source of both contracting and relaxing factors.22,31,57 Following th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7908f0f32c0b43258ce50cbd4619783
https://doi.org/10.1007/978-1-4614-7514-9_6
https://doi.org/10.1007/978-1-4614-7514-9_6
Publikováno v:
Endothelin ISBN: 9781461475149
In an attempt to “bioassay” endothelium-derived relaxing factor (EDRF) produced by cultured bovine aortic endothelial cells, it was discovered by Hickey et al.7 that the conditioned medium contained a potent vasoconstrictor substance (see Chapter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7051ae25cb328c93690e18b411bdee55
https://doi.org/10.1007/978-1-4614-7514-9_3
https://doi.org/10.1007/978-1-4614-7514-9_3
Publikováno v:
Biochemical and biophysical research communications. 172(1)
The equilibrium binding, kinetics of ligand-receptor interactions, and biological activity of endothelin-1 and -2 have been studied in Swiss 3T3 fibroblasts. Scatchard analyses of saturation binding data for ET-1 and -2, performed at 4 degrees C to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292aff50bd7e2ea71ed4cbb11a62ea00
https://pubmed.ncbi.nlm.nih.gov/2171515
https://pubmed.ncbi.nlm.nih.gov/2171515