Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Penny E Lovat"'
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0265048 (2022)
ObjectivesCutaneous melanoma rates are steadily increasing. Up to 20% of patients diagnosed with AJCC Stage I/II melanomas will develop metastatic disease. To date there are no consistently reliable means to accurately identify truly high versus low-
Externí odkaz:
https://doaj.org/article/b066aa54756a40b0a9efe11e4085744b
Autor:
Jing Xuan Lim, Chester Y. Lai, Grace E. Mallett, David McDonald, Gillian Hulme, Stephanie Laba, Andrew Shapanis, Megan Payne, Warren Patterson, Michael Alexander, Jonathan Coxhead, Andrew Filby, Ruth Plummer, Penny E. Lovat, Giuseppe Sciume, Eugene Healy, Shoba Amarnath
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Innate Lymphoid Cells (ILCs) play a key role in tissue mediated immunity and can be controlled by co-receptor signaling. Here we define a subset of ILCs that are Tbet+NK1.1− and are present within the tumor microenvironment (TME). We show programme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b0ca8e4c56fb8d709842ce8fe996c6
https://doi.org/10.1073/pnas.2216587120
https://doi.org/10.1073/pnas.2216587120
Autor:
Penny E. Lovat, Stefan Przyborski, Jane L. Armstrong, Edel A. O'Toole, Mei Chen, Matthew P. Caley, Neil D.P. Robinson, David S. Hill
supplementary figure 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c003a179c735f86e6c89638a757ff9
https://doi.org/10.1158/1535-7163.22506084
https://doi.org/10.1158/1535-7163.22506084
Autor:
Penny E. Lovat, Stefan Przyborski, Jane L. Armstrong, Edel A. O'Toole, Mei Chen, Matthew P. Caley, Neil D.P. Robinson, David S. Hill
Metastatic melanoma remains incurable, emphasizing the acute need for improved research models to investigate the underlying biologic mechanisms mediating tumor invasion and metastasis, and to develop more effective targeted therapies to improve clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9da2f8de5ecc15c3d3bf6d71cfdd0f71
https://doi.org/10.1158/1535-7163.c.6538287.v1
https://doi.org/10.1158/1535-7163.c.6538287.v1
Autor:
Penny E. Lovat, Stefan Przyborski, Jane L. Armstrong, Edel A. O'Toole, Mei Chen, Matthew P. Caley, Neil D.P. Robinson, David S. Hill
legend to supplementary figure 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc7154b47874dc58e372b8c0e1c3775
https://doi.org/10.1158/1535-7163.22506087
https://doi.org/10.1158/1535-7163.22506087
Autor:
Penny E. Lovat, Mauro Piacentini, Gian Maria Fimia, Christopher P.F. Redfern, Salim Al Sabah, Nicola Ellis, David S. Hill, Laura Falasca, Vittoria Pagliarini, Shaun Martin, Marco Corazzari, Jane L. Armstrong
Purpose: Metastatic melanoma is characterized by extremely poor survival rates and hence novel therapies are urgently required. The ability of many anticancer drugs to activate autophagy, a lysosomal-mediated catabolic process which usually promotes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d0cd1d4a9abe45d1cc6ca995ba2b2e
https://doi.org/10.1158/1078-0432.c.6519183
https://doi.org/10.1158/1078-0432.c.6519183
Autor:
Penny E. Lovat, Mauro Piacentini, Gian Maria Fimia, Christopher P.F. Redfern, Salim Al Sabah, Nicola Ellis, David S. Hill, Laura Falasca, Vittoria Pagliarini, Shaun Martin, Marco Corazzari, Jane L. Armstrong
Supplementary Figures S1-S5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c0d5e2c013ab3d84890316343e2d31
https://doi.org/10.1158/1078-0432.22442466.v1
https://doi.org/10.1158/1078-0432.22442466.v1
Autor:
John D. Widdrington, Aurora Gomez-Duran, Angela Pyle, Marie-Helene Ruchaud-Sparagano, Jonathan Scott, Simon V. Baudouin, Anthony J. Rostron, Penny E. Lovat, Patrick F. Chinnery, A. John Simpson
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
In order to limit the adverse effects of excessive inflammation, anti-inflammatory responses are stimulated at an early stage of an infection, but during sepsis these can lead to deactivation of immune cells including monocytes. In addition, there is
Externí odkaz:
https://doaj.org/article/e3d3a40efb8e4b5e9c5d241718315a08
Autor:
Minna Honkanen-Scott, Kirsty S. Cullen, James Shaw, Merilin Georgiou, Penny E. Lovat, Catherine Arden, Vadivel Parthsarathy, Finbarr O'Harte, Stanislaus I Krishnanda, Francesco P Zummo
Publikováno v:
Autophagy. 18:799-815
Macroautophagy/autophagy is critical for the regulation of pancreatic β-cell mass and its deregulation has been implicated in the pathogenesis of type 2 diabetes (T2D). We have previously shown that treatment of pancreatic β-cells with the GLP1R (g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d4e206b7416dd3074c09c817ed6cb4d
https://doi.org/10.1080/15548627.2021.1956123
https://doi.org/10.1080/15548627.2021.1956123
Autor:
Catherine Richmond, Dawn Craig, Margaret Astin, Mohamed Shawgi, Marie Labus, Patience Kunonga, Dalvir Bajwa, Mehdi Javanbakht, Vasileios Kontogiannis, Dor Wilson, Fiona Beyer, Penny E. Lovat, Andrew Bryant, Batoul Nasr, Timothy Cunliffe, Luke Vale, Pamela Royle, Helena Hinde, Wanwuri Akor, Robert Ellis, Daniel Saleh, Rachel Lucas, Paul Steward, Diarmuid Coughlan
Publikováno v:
Health Technology Assessment, Vol 25, Iss 64 (2021)
Background Malignant melanoma is the fifth most common cancer in the UK, with rates continuing to rise, resulting in considerable burden to patients and the NHS. Objectives The objectives were to evaluate the effectiveness and cost-effectiveness of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7026be0d85026519edfd5bb2ad9fe51b
https://doaj.org/article/21247debab3e4d9bb4ce2c282c8aa36f
https://doaj.org/article/21247debab3e4d9bb4ce2c282c8aa36f