Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Penny A. Jeggo"'
Autor:
Selvakumar Anbalagan, Cecilia Ström, Jessica A. Downs, Penny A. Jeggo, David McBay, Anna Wilkins, Kai Rothkamm, Kevin J. Harrington, John R. Yarnold, Navita Somaiah
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Recent clinical trials in breast and prostate cancer have established that fewer, larger daily doses (fractions) of radiotherapy are safe and effective, but these do not represent personalised dosing on a patient-by-patient basis. Understand
Externí odkaz:
https://doaj.org/article/c9e7edacfb97484e949e3d81da55de3a
Autor:
Bharath Sampadi, Sylvia Vermeulen, Branislav Mišovic, Jan J. Boei, Tanveer S. Batth, Jer-Gung Chang, Michelle T. Paulsen, Brian Magnuson, Joost Schimmel, Hanneke Kool, Cyriel S. Olie, Bart Everts, Alfred C. O. Vertegaal, Jesper V. Olsen, Mats Ljungman, Penny A. Jeggo, Leon H. F. Mullenders, Harry Vrieling
Publikováno v:
Cells, Vol 11, Iss 23, p 3794 (2022)
Cancer risk after ionizing radiation (IR) is assumed to be linear with the dose; however, for low doses, definite evidence is lacking. Here, using temporal multi-omic systems analyses after a low (LD; 0.1 Gy) or a high (HD; 1 Gy) dose of X-rays, we s
Externí odkaz:
https://doaj.org/article/c1d30103c56243f683bc88e1eec647e6
Autor:
Aaron A. Goodarzi, Penny A. Jeggo
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 9, Pp 11844-11860 (2012)
Over recent decades, a deep understanding of pathways that repair DNA double strand breaks (DSB) has been gained from biochemical, structural, biophysical and cellular studies. DNA non-homologous end-joining (NHEJ) and homologous recombination (HR) r
Externí odkaz:
https://doaj.org/article/0361b2b65b5f40749b7d9b2e2973e6a4
Autor:
Anthony J. Chalmers, Penny A. Jeggo, Lisa J. Woodbine, Akiko K. Shibata, Atsushi Shibata, Dana A. Löser
Supplementary Data from Sensitization to Radiation and Alkylating Agents by Inhibitors of Poly(ADP-ribose) Polymerase Is Enhanced in Cells Deficient in DNA Double-Strand Break Repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d1eab3645e208bd84ec85ed2ede9a9
https://doi.org/10.1158/1535-7163.22485929.v1
https://doi.org/10.1158/1535-7163.22485929.v1
Autor:
Anthony J. Chalmers, Penny A. Jeggo, Lisa J. Woodbine, Akiko K. Shibata, Atsushi Shibata, Dana A. Löser
As single agents, chemical inhibitors of poly(ADP-ribose) polymerase (PARP) are nontoxic and have clinical efficacy against BRCA1- and BRCA2-deficient tumors. PARP inhibitors also enhance the cytotoxicity of ionizing radiation and alkylating agents b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02ba54939d63c70e45f0e55f4245f00
https://doi.org/10.1158/1535-7163.c.6532151
https://doi.org/10.1158/1535-7163.c.6532151
Supplementary Figure 1 from ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c8f1410c21665a72fbe68176f52071
https://doi.org/10.1158/0008-5472.22363565.v1
https://doi.org/10.1158/0008-5472.22363565.v1
Supplementary Methods, Figure Legends 1-4 from The Limitations of the G1-S Checkpoint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3281d5e86a36b0db00a4823c1035d2cf
https://doi.org/10.1158/0008-5472.22382066.v1
https://doi.org/10.1158/0008-5472.22382066.v1
H2AX phosphorylation is an early step in the response to DNA damage. It is widely accepted that ATM (ataxia telangiectasia mutated protein) phosphorylates H2AX in response to DNA double-strand breaks (DSBs). Whether DNA-dependent protein kinase (DNA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d09dcc42048f5746cfec316ed4c983a
https://doi.org/10.1158/0008-5472.c.6493778.v1
https://doi.org/10.1158/0008-5472.c.6493778.v1
Supplementary Figure 5 from The Limitations of the G1-S Checkpoint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25826e479c9912977e88a7715c4d6f81
https://doi.org/10.1158/0008-5472.22382069
https://doi.org/10.1158/0008-5472.22382069
Supplementary Figure 3 from The Limitations of the G1-S Checkpoint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b48472996cf2a28c23f62870cb92b80
https://doi.org/10.1158/0008-5472.22382075.v1
https://doi.org/10.1158/0008-5472.22382075.v1