Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Penny A. F. Whiley"'
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Correct fetal testis development underpins adult male fertility, and TGFβ superfamily ligands control key aspects of this process. Transcripts encoding one such ligand, activin A, are upregulated in testes after sex determination and remain high unt
Externí odkaz:
https://doaj.org/article/119f21d600c041728fe5984a222b8f2b
Spermatogonial fate in mice with increased activin A bioactivity and testicular somatic cell tumours
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Adult male fertility depends on spermatogonial stem cells (SSCs) which undergo either self-renewal or differentiation in response to microenvironmental signals. Activin A acts on Sertoli and Leydig cells to regulate key aspects of testis development
Externí odkaz:
https://doaj.org/article/0206b3d1ce1449d0bb1b99aa6426ecc0
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The long-standing knowledge that Sertoli cells determine fetal testosterone production levels is not widespread, despite being first reported over a decade ago in studies of mice. Hence any ongoing use of testosterone as a marker of Leydig cell funct
Externí odkaz:
https://doaj.org/article/2dee3060aab44dd4a35f2277ff0e9862
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Activin A, a TGFβ superfamily member, is important for normal testis development through its actions on Sertoli cell development. Our analyses of altered activin A mouse models indicated gonocyte abnormalities, implicating activin A as a key determi
Externí odkaz:
https://doaj.org/article/1cca202fbcd24948b73ee09bf267d8a9
Autor:
Yoichi Miyamoto, Penny A. F. Whiley, Hoey Y. Goh, Chin Wong, Gavin Higgins, Taro Tachibana, Paul G. McMenamin, Lynne Mayne, Kate L. Loveland
Publikováno v:
Biology Open, Vol 7, Iss 8 (2018)
Serine/threonine kinase 35 (STK35) is a recently identified human kinase with an autophosphorylation function, linked functionally to actin stress fibers, cell cycle progression and survival. STK35 has previously been shown to be highly expressed in
Externí odkaz:
https://doaj.org/article/af822dbce52e485f81231b5f0aa20243
Publikováno v:
Seminars in celldevelopmental biology. 121
Regulated nucleocytoplasmic transport is central to the changes in gene expression that underpin cellular development and homeostasis, including in the testis, and proteins in the importin family are the predominant facilitators of cargo transport th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86be2b8452164505afa2d1f0229c6cb7
https://pubmed.ncbi.nlm.nih.gov/34426066
https://pubmed.ncbi.nlm.nih.gov/34426066
Autor:
Kate L Loveland, Sarah C Moody, Julia C. Young, Patrick S Western, David J. Handelsman, Elizabeth A. Richards, Kristian Almstrup, Liza O'Donnell, Penny A. F. Whiley
Publikováno v:
Endocrinology. 161
Activin A promotes fetal mouse testis development, including driving Sertoli cell proliferation and cord morphogenesis, but its mechanisms of action are undefined. We performed ribonucleic acid sequencing (RNA-seq) on testicular somatic cells from fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc52f2239b80a450aaad80613a032c42
https://doi.org/10.1210/endocr/bqaa058
https://doi.org/10.1210/endocr/bqaa058
Autor:
Masahiro Oka, Mayumi Otani, Jun Adachi, Masaru Okabe, Masahiro Nagai, Yoichi Miyamoto, Yoshihiro Yoneda, Masahito Ikawa, Haruhiko Miyata, Akane Morohoshi, Junichiro Matsuda, Mitsuho Sasaki, Penny A. F. Whiley, Ken-ichi Akagi, Kate L Loveland, Yoko Monobe, Shinya Oki
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(12)
Importin α proteins play a central role in the transport of cargo from the cytoplasm to the nucleus. In this study, we observed that male knock-out mice for importin α4, which is encoded by the Kpna4 gene (Kpna4-/- ), were subfertile and yielded sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0bfe6c27881e7e37df7f183ad2989e1
https://pubmed.ncbi.nlm.nih.gov/33058343
https://pubmed.ncbi.nlm.nih.gov/33058343
Autor:
Chin Wong, Penny A. F. Whiley, Kate L Loveland, Taro Tachibana, Gavin C Higgins, Yoichi Miyamoto, Hoey Y. Goh, Paul G. McMenamin, Lynne Mayne
Publikováno v:
Biology Open
Biology Open, Vol 7, Iss 8 (2018)
Biology Open, Vol 7, Iss 8 (2018)
Serine/threonine kinase 35 (STK35) is a recently identified human kinase with an autophosphorylation function, linked functionally to actin stress fibers, cell cycle progression and survival. STK35 has previously been shown to be highly expressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cfa06eebf18afc8052f32f333c3035
https://doi.org/10.1242/bio.032631
https://doi.org/10.1242/bio.032631
Autor:
Julia Young, David A. Jans, Penny A. F. Whiley, Kate L Loveland, Yoichi Miyamoto, Yoshihiro Yoneda, Arash Arjomand
Publikováno v:
Reproduction Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::114df6936fbead9701915f701ee11e39
https://doi.org/10.1530/repabs.1.s005
https://doi.org/10.1530/repabs.1.s005