Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Penny A MacDonald"'
Autor:
Erind Alushaj, Dimuthu Hemachandra, Hooman Ganjavi, Ken N. Seergobin, Manas Sharma, Alia Kashgari, Jennifer Barr, William Reisman, Ali R. Khan, Penny A. MacDonald
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract Idiopathic rapid eye movement sleep behaviour disorder (iRBD)—a Parkinson’s disease (PD) prodrome—might exhibit neural changes similar to those in PD. Substantia nigra pars compacta (SNc) degeneration underlies motor symptoms of PD. In
Externí odkaz:
https://doaj.org/article/39e858f28c174edebc48170f23ffe471
Autor:
Chloe A. Stewart, Derek G. V. Mitchell, Penny A. MacDonald, Stephen H. Pasternak, Paul F. Tremblay, Elizabeth C. Finger
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Guilt is a negative emotion elicited by realizing one has caused actual or perceived harm to another person. One of guilt’s primary functions is to signal that one is aware of the harm that was caused and regrets it, an indication that the
Externí odkaz:
https://doaj.org/article/f27f3b49f7e146d5ab10ba71bde3bfed
Autor:
Erind Alushaj, Nicholas Handfield-Jones, Alan Kuurstra, Anisa Morava, Ravi S. Menon, Adrian M. Owen, Manas Sharma, Ali R. Khan, Penny A. MacDonald
Publikováno v:
NeuroImage: Clinical, Vol 41, Iss , Pp 103577- (2024)
Degeneration in the substantia nigra (SN) pars compacta (SNc) underlies motor symptoms in Parkinson’s disease (PD). Currently, there are no neuroimaging biomarkers that are sufficiently sensitive, specific, reproducible, and accessible for routine
Externí odkaz:
https://doaj.org/article/39dfea95398a48f3919a91ed6410283b
Autor:
Abdullah Al Jaja, Téa Sue, Margaret Prenger, Ken N. Seergobin, Jessica A. Grahn, Penny A. MacDonald
Publikováno v:
Parkinson's Disease, Vol 2024 (2024)
Background. Freezing of gait (FOG) is an intractable motor symptom in Parkinson’s disease (PD) that increases fall risk and impairs the quality of life. FOG has been associated with anxiety, with experimental support for the notion that anxiety its
Externí odkaz:
https://doaj.org/article/6096c03cb4984144aa55c768f773f884
Autor:
Nole M. Hiebert, Marc R. Lawrence, Hooman Ganjavi, Mark Watling, Adrian M. Owen, Ken N. Seergobin, Penny A. MacDonald
Publikováno v:
Frontiers in Psychiatry, Vol 11 (2020)
Obsessive compulsive disorder (OCD) is a prevalent psychiatric disorder characterized by obsessions and compulsions. Studies investigating symptomatology and cognitive deficits in OCD frequently implicate the striatum. The aim of this study was to ex
Externí odkaz:
https://doaj.org/article/be694ba2b7c34a02a2f740354fc386fa
Autor:
Margaret T. M. Prenger, Racheal Madray, Kathryne Van Hedger, Mimma Anello, Penny A. MacDonald
Publikováno v:
Parkinson's Disease, Vol 2020 (2020)
Parkinson’s disease (PD) is typically well recognized by its characteristic motor symptoms (e.g., bradykinesia, rigidity, and tremor). The cognitive symptoms of PD are increasingly being acknowledged by clinicians and researchers alike. However, PD
Externí odkaz:
https://doaj.org/article/e8fd557b910b40dfb294a5e142d3c686
Autor:
Chloe A. Stewart, Derek G.V. Mitchell, Penny A. MacDonald, Stephen H. Pasternak, Paul F. Tremblay, Elizabeth Finger
Publikováno v:
Cognitive, Affective, & Behavioral Neuroscience.
Guilt is a negative emotion, elicited by realizing one has caused actual or perceived harm to another person. Anecdotally, guilt often is described as a visceral and physical experience. However, while the way that the body responds to and contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a5253abd8534484b0dd1759417859aa
https://doi.org/10.3758/s13415-023-01079-3
https://doi.org/10.3758/s13415-023-01079-3
Autor:
Ali R. Khan, Nole M. Hiebert, Andrew Vo, Brian T. Wang, Adrian M. Owen, Ken N. Seergobin, Penny A. MacDonald
Publikováno v:
NeuroImage: Clinical, Vol 21, Iss , Pp - (2019)
Parkinson's disease (PD) is a progressive neurological disorder that has no reliable biomarkers. The aim of this study was to explore the potential of semi-automated sub-regional analysis of the striatum with magnetic resonance imaging (MRI) to disti
Externí odkaz:
https://doaj.org/article/9e7c940acd5f44bdbdadf4bbf57b6940
Autor:
Brian D. Robertson, Abdullah S. Al Jaja, Alex A. MacDonald, Nole M. Hiebert, Ruzbeh Tamjeedi, Ken N. Seergobin, Ute I. Schwarz, Richard B. Kim, Penny A. MacDonald
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
In Parkinson's disease (PD), cognitive functions mediated by brain regions innervated by ventral tegmental area (VTA) worsen with dopamine replacement therapy, whereas processes relying on regions innervated by the substantia nigra pars compacta (SNc
Externí odkaz:
https://doaj.org/article/314c8fd4b0544ebca4add52439955025
Publikováno v:
Parkinson's Disease, Vol 2018 (2018)
Difficulty with emotion recognition is increasingly being recognized as a symptom of Parkinson’s disease. Most research into this area contends that progressive cognitive decline accompanying the disease is to be blamed. However, facial mimicry (i.
Externí odkaz:
https://doaj.org/article/1f34f17e107f426580b91ea4423ef633