Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Penny, Lovat"'
1
Akademický článek
Predictive accuracy of risk prediction models for recurrence, metastasis and survival for early-stage cutaneous melanoma: a systematic review
Autor: Andrew Bryant, Fiona Pearson, Luke Vale, Dawn Craig, Diarmuid Coughlan, Catherine Richmond, Tafadzwa Patience Kunonga, Robert Ellis, Fiona R Beyer, R P W Kenny, Margaret Astin, Vasileios Kontogiannis, Claire H Eastaugh, Penny Lovat
Publikováno v: BMJ Open, Vol 13, Iss 9 (2023)
Objectives To identify prognostic models for melanoma survival, recurrence and metastasis among American Joint Committee on Cancer stage I and II patients postsurgery; and evaluate model performance, including overall survival (OS) prediction.Design
Externí odkaz: https://doaj.org/article/0e3c7e7f67dd46f6bc388388a402a56f
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2
Akademický článek
Optimal surveillance strategies for patients with stage 1 cutaneous melanoma post primary tumour excision: three systematic reviews and an economic model
Autor: Luke Vale, Patience Kunonga, Diarmuid Coughlan, Vasileios Kontogiannis, Margaret Astin, Fiona Beyer, Catherine Richmond, Dor Wilson, Dalvir Bajwa, Mehdi Javanbakht, Andrew Bryant, Wanwuri Akor, Dawn Craig, Penny Lovat, Marie Labus, Batoul Nasr, Timothy Cunliffe, Helena Hinde, Mohamed Shawgi, Daniel Saleh, Pam Royle, Paul Steward, Rachel Lucas, Robert Ellis
Publikováno v: Health Technology Assessment, Vol 25, Iss 64 (2021)
Background: Malignant melanoma is the fifth most common cancer in the UK, with rates continuing to rise, resulting in considerable burden to patients and the NHS. Objectives: The objectives were to evaluate the effectiveness and cost-effectiveness of
Externí odkaz: https://doaj.org/article/21247debab3e4d9bb4ce2c282c8aa36f
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3
Akademický článek
TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response
Autor: Chiao-En Wu, Tsin Shue Koay, Yi-Hsuan Ho, Penny Lovat, John Lunec
Publikováno v: Cancer Cell International, Vol 19, Iss 1, Pp 1-15 (2019)
Abstract Background Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with chemotherapeutic agents but might not with targeted agents. Methods In
Externí odkaz: https://doaj.org/article/d52f6c520f674aa0ad3934c0311b3100
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6
Akademický článek
Prognostic impact of autophagy biomarkers for cutaneous melanoma.
Autor: Diana Yao Li Tang, Robert Ellis, Penny Lovat
Publikováno v: Frontiers in Oncology, Vol 6 (2016)
Prognosis and survival for malignant melanoma is highly dependent on early diagnosis and treatment. While the American Joint Committee on Cancer (AJCC) criteria provides a means of staging melanomas and guiding treatment approaches, it is unable to i
Externí odkaz: https://doaj.org/article/8bc770ee53b34e72b6095dbbf067e2bd
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8
Discovery of AMBRA1 and SQSTM1 (p62) as putative biomarkers to identify high risk subsets of patients with cutaneous squamous cell carcinoma
Autor: Penny Lovat, Michael Alexander, William Cousins, Tom Ewen, Niki Stefanos
Publikováno v: Journal of Clinical Oncology. 40:e21541-e21541
e21541 Background: While surgical excision is largely curative, small subsets of patients with cSCC develop metastatic disease for which current AJCC/Brigham and Women’s Hospital staging criteria are unable to reliably identify. There is hence an u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b69794fec3190feed2059b7c6ecbfad8
https://doi.org/10.1200/jco.2022.40.16_suppl.e21541
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9
Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing
Autor: Bernadette, Carroll, Glyn, Nelson, Yoana, Rabanal-Ruiz, Olena, Kucheryavenko, Natasha A, Dunhill-Turner, Charlotte C, Chesterman, Qabil, Zahari, Tong, Zhang, Sarah E, Conduit, Christina A, Mitchell, Oliver D K, Maddocks, Penny, Lovat, Thomas, von Zglinicki, Viktor I, Korolchuk
Publikováno v: The Journal of Cell Biology
It is unclear how mTORC1 signaling differs in senescent and young cells. Carroll et al. show that senescence leads to constitutive mTORC1 activation and resistance to serum and amino acid starvation. This is associated with elevated autophagy, depola
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::673596468061702af9a8d1ee7f824fcf
https://pubmed.ncbi.nlm.nih.gov/28566325
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