Zobrazeno 1 - 10 of 1 520 pro vyhledávání: '"Pennsylvania School of Veterinary Medicine"'
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Long-term safety and efficacy of lentiviral hematopoietic stem/progenitor cell gene therapy for Wiskott-Aldrich syndrome
Autor: Magnani, A., Semeraro, M., Adam, F., Booth, C., Dupré, L., Morris, E. C., Gabrion, A., Roudaut, C., Borgel, D., Toubert, A., Clave, E., Abdo, C., Gorochov, G., Petermann, R., Guiot, M., Miyara, M., Moshous, D., Magrin, E., Denis, A., Suarez, F., Lagresle, C., Roche, A. M., Everett, J., Trinquand, A., Guisset, M., Bayford, J. Xu, Hacein-Bey-Abina, S., Kauskot, A., Elfeky, R., Rivat, C., Abbas, S., Gaspar, H. B., Macintyre, E., Picard, C., Bushman, F. D., Galy, A., Fischer, A., Six, E., Thrasher, A. J., Cavazzana, M.
Publikováno v: NATURE MEDICINE
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Universidad de las Islas Baleares
Nature Medicine
Nature Medicine, 2022, 28 (1), pp.71-80. ⟨10.1038/s41591-021-01641-x⟩
Patients with Wiskott–Aldrich syndrome (WAS) lacking a human leukocyte antigen-matched donor may benefit from gene therapy through the provision of gene-corrected, autologous hematopoietic stem/progenitor cells. Here, we present comprehensive, long
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3f98b89d4b68a773ab2a2e9643726a
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21058
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3
T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency
Autor: Nadia A. Kadry, A. Jesse Connell, Emmanuelle Six, Rebecca A. Marsh, Marina Cavazzana, Ronald G. Collman, Alain Fischer, Erik L. Clarke, Sung-Yun Pai, David A. Williams, Myriam Armant, Judith R. Kelsen, Arwa Abbas, Luigi D. Notarangelo, Frederic D. Bushman, Young Hwang, John K. Everett, Donald B. Kohn, Salima Hacein-Bey-Abina, Casey E. Hofstaedter
Publikováno v: Genome Medicine
Genome Medicine, BioMed Central, 2018, 10, ⟨10.1186/s13073-018-0580-z⟩
Genome medicine, vol 10, iss 1
Genome Medicine, Vol 10, Iss 1, Pp 1-14 (2018)
Genome Medicine, 2018, 10, ⟨10.1186/s13073-018-0580-z⟩
Background Mutation of the IL2RG gene results in a form of severe combined immune deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene therapy. SCID-X1 gene therapy results in reconstitution of the previously la
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4eed43fe7a65e238dfe325b8796a63
http://europepmc.org/articles/PMC6161392
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4
Impact of biomaterial microtopography on bone regeneration: comparison of three hydroxyapatites
Autor: Pierre Layrolle, Eric Rompen, Miljana Bacevic, Peter Schupbach, Pierre Drion
Publikováno v: Clinical Oral Implants Research
Clinical Oral Implants Research, Wiley, 2017, 28 (10), pp.e201-e207. ⟨10.1111/clr.12986⟩
International audience; Aims: The primary objective of this study was to compare the in vivo performance, namely in terms of quantity of newly formed bone and bone-to-material contact (osteoconductivity), of three hydroxyapatite-based biomaterials (H
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f265d8d440f82b166df9dfcb5b724a66
https://www.hal.inserm.fr/inserm-01701071/document
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5
Identification of primordial organized lymphoid structure in the spleen of teleost fish
Autor: Pierre Boudinot, Aleksei Krasnov, Yasuhiro Shibasaki, Fumio Takizawa, Yang Ding, J. Oriol Sunyer
Publikováno v: Fish and Shellfish Immunology
Fish and Shellfish Immunology, Elsevier, 2019, 91, pp.428. ⟨10.1016/j.fsi.2019.04.172⟩
Induction of adaptive immune responses in higher vertebrate species occur within organized lymphoid structures (e.g. lymph nodes, Peyer’s patches). It has been proposed that such structures emerged throughout evolutionary time with the goal to maxi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16c56820549ab171687cfe8c3b3c3c4
https://doi.org/10.1016/j.fsi.2019.04.172
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6
Cathepsin-Mediated Alterations in TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting
Autor: Heather, Flanagan-Steet, Megan, Aarnio, Brian, Kwan, Pierre, Guihard, Aaron, Petrey, Mark, Haskins, Frederic, Blanchard, Richard, Steet
Publikováno v: Journal of Bone and Mineral Research
Journal of Bone and Mineral Research, American Society for Bone and Mineral Research, 2016, 31 (3), pp.535-548. ⟨10.1002/jbmr.2722⟩
International audience; Hypersecretion of acid hydrolases is a hallmark feature of mucolipidosis II (MLII), a lysosomal storage disease caused by loss of carbohydrate-dependent lysosomal targeting. Inappropriate extracellular action of these hydrolas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::85d756aa04cd26755847464f97551260
https://www.hal.inserm.fr/inserm-01702333
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7
RIAM Links the ADAP/SKAP-55 Signaling Module to Rap1, Facilitating T-Cell-Receptor-Mediated Integrin Activation
Autor: Theresia E. B. Stradal, Stefanie Kliche, Gaël Ménasché, Gary A. Koretzky, Burkhart Schraven, Emily J. H. Chen
Publikováno v: Molecular and Cellular Biology
Molecular and Cellular Biology, 2007, 27 (11), pp.4070-4081. ⟨10.1128/MCB.02011-06⟩
International audience; One outcome of T-cell receptor (TCR) signaling is increased affinity and avidity of integrins for their ligands. This occurs through a process known as inside-out signaling, which has been shown to require several molecular co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569f002e657dfd66b9a92f9958d1a3cb
https://doi.org/10.1128/mcb.02011-06
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8
One-Step Identification of Five Prominent Chicken Salmonella Serovars and Biotypes
Autor: Chunhong Zhu, Joachim Frey, Shelley C. Rankin, Dieter M. Schifferli, Min Yue, François-Xavier Weill
Publikováno v: Journal of Clinical Microbiology
Journal of Clinical Microbiology, American Society for Microbiology, 2015, 53 (12), pp.3881-3. ⟨10.1128/JCM.01976-15⟩
Journal of Clinical Microbiology, 2015, 53 (12), pp.3881-3. ⟨10.1128/JCM.01976-15⟩
Based on bacterial genomic data, we developed a one-step multiplex PCR assay to identify Salmonella and simultaneously differentiate the two invasive avian-adapted S. enterica serovar Gallinarum biotypes Gallinarum and Pullorum, and the most frequent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6916dcf5bb983dd3079e3c5633437b2e
https://europepmc.org/articles/PMC4652083/
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9
Allelic variation contributes to bacterial host specificity
Autor: Xiangan Han, Jacques Mainil, Renwei Wu, W. Florian Fricke, Shelley C. Rankin, François-Xavier Weill, Chunhong Zhu, Dieter M. Schifferli, Robert Schmieder, Shaohua Zhao, Robert Edwards, Nan Zhang, Leon De Masi, Patrick F. McDermott, Radhey S. Kaushik, Xun Ma, Min Yue, Cesar Arze, Junjie Zhang, George P. Fraser, Dustin Brisson
Publikováno v: Nature Communications
Nature Communications, 2015, 6 (6), pp.8754. ⟨10.1038/ncomms9754⟩
Nature Communications, Nature Publishing Group, 2015, 6 (6), pp.8754. ⟨10.1038/ncomms9754⟩
Understanding the molecular parameters that regulate cross-species transmission and host adaptation of potential pathogens is crucial to control emerging infectious disease. Although microbial pathotype diversity is conventionally associated with gen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ca3eaa87708db3cd6b24a160ba0860
https://doi.org/10.1038/ncomms9754
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10
Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice
Autor: Sandrine Henri, David Artis, Allan McI. Mowat, Lisa C. Osborne, Bernard Malissen, Frederic Geissmann, Charlotte L. Scott, Calum C. Bain, Elisa Gomez Perdiguero, Alberto Bravo-Blas
Publikováno v: Nature Immunology
Nature Immunology, 2014, 15 (10), pp.929-937. ⟨10.1038/ni.2967⟩
Nature immunology
Bain, C C, Bravo-Blas, A, Scott, C L, Gomez Perdiguero, E, Geissmann, F, Henri, S, Malissen, B, Osborne, L C, Artis, D & Mowat, A M 2014, ' Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice ', Nature Immunology, vol. 15, no. 10, pp. 929-937 . https://doi.org/10.1038/ni.2967
Nature Immunology, Nature Publishing Group, 2014, 15 (10), pp.929-937. ⟨10.1038/ni.2967⟩
International audience; The paradigm that macrophages that reside in steady-state tissues are derived from embryonic precursors has never been investigated in the intestine, which contains the largest pool of macrophages. Using fate-mapping models an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddc434704d8e16842d8ba0bd4d20eb7
https://hal.science/hal-03263928
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