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Use of Serum Micro RNA s as Biomarker for Hepatobiliary Diseases in Dogs

Autor: Dirksen, K, Verzijl, T, Grinwis, G C, Favier, R P, Penning, L C, Burgener, I A, van der Laan, L J, Fieten, H, Spee, B, dPB CR, dCSCA RMSC-1, Regenerative Medicine, Stem Cells & Cancer, Veterinair Pathologisch Diagnostisch Cnt, Dep Pathobiologie, dCSCA AVR

Publikováno v: Journal of Veterinary Internal Medicine, 30(6), 1816. Wiley-Blackwell
Journal of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine, 30(6), 1816-1823. Wiley-Blackwell

Background Current biochemical indicators cannot discriminate between parenchymal, biliary, vascular, and neoplastic hepatobiliary diseases. MicroRNAs are promising new biomarkers for hepatobiliary disease in humans and dogs. Objective To measure ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fe37c1c69a14723e5512cb1ce1b011
https://doi.org/10.1111/jvim.14602

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The mRNA expression of PTTG1 is a strong prognostic indicator for recurrence after hypophysectomy in dogs with corticotroph pituitary adenomas

Autor: Vastenhout, N, van Rijn, S J, Riemers, F M, Tryfonidou, M A, Meij, B P, Penning, L C, Biochemisch laboratorium, Orthopedie en neurochirurgie, LS Algemene chirurgie, Onderzoek, dCSCA RMSC-1, dCSCA AVR

Publikováno v: Veterinary Journal, 240, 19. Bailliere Tindall Ltd

Pituitary-dependent hypercortisolism (PDH) is a common endocrinopathy in dogs, but the promotors and initiators of the tumourigenesis of corticotroph pituitary adenomas remain unknown. Based on human data, we investigated mRNA expression of pituitary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9fcd5fad834d810ea57c7e72bb8c560
https://pubmed.ncbi.nlm.nih.gov/30268327

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Sensitivity and Specificity of Plasma ALT, ALP, and Bile Acids for Hepatitis in Labrador Retrievers

Autor: Dirksen, K, Burgener, I A, Rothuizen, J, van den Ingh, T S G A M, Penning, L C, Spee, B, Fieten, H, dCSCA RMSC-1, dCSCA AVR

Publikováno v: Journal of Veterinary Internal Medicine, 31. Wiley-Blackwell
Journal of Veterinary Internal Medicine

Background Biochemical indicators for diagnosing liver disease are plasma alanine aminotransferase activity (ALT), alkaline phosphatase activity (ALP), and bile acid concentration (BA). Objectives To determine the sensitivity and specificity of ALT,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5feb80c3350ac00c108bd4c3c94e309
https://dspace.library.uu.nl/handle/1874/360419

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Erythrocyte copper chaperone for superoxide dismutase and superoxide dismutase as biomarkers for hepatic copper concentrations in Labrador retrievers

Autor: Dirksen, K, Roelen, Y S, van Wolferen, M E, Kruitwagen, H S, Penning, L C, Burgener, I A, Spee, B, Fieten, H, dCSCA RMSC-1, dCSCA AVR

Publikováno v: Veterinary Journal, 218, 1. Bailliere Tindall Ltd

Hereditary hepatic copper accumulation in Labrador retrievers leads to hepatitis with fibrosis and eventually cirrhosis. The development of a non-invasive blood-based biomarker for copper status in dogs could be helpful in identifying dogs at risk an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591b8ab13b71a4124535771013a72ef6
https://dspace.library.uu.nl/handle/1874/345556

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The Influence of Pituitary Size on Outcome After Transsphenoidal Hypophysectomy in a Large Cohort of Dogs with Pituitary-Dependent Hypercortisolism

Autor: van Rijn, Sarah, Galac, S., Tryfonidou, M. A., Hesselink, J. W., Penning, L. C., Kooistra, H. S., Meij, B. P., dCSCA RMSC-1, dCSCA RMSC-2, Opleiding chirurgie, Sub Endocrinologie, Orthopedie en neurochirurgie, Geneeskunde van gezelschapsdieren, Zorgfaciliteiten leiding, Onderzoek, LS Algemene chirurgie, dCSCA AVR

Publikováno v: Journal of Veterinary Internal Medicine, 30(4), 989. Wiley-Blackwell
Journal of Veterinary Internal Medicine

Background Transsphenoidal hypophysectomy is one of the treatment strategies in the comprehensive management of dogs with pituitary‐dependent hypercortisolism (PDH). Objectives To describe the influence of pituitary size at time of pituitary gland

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e993ed6e4eb50e8d744c2f7889694927
https://dspace.library.uu.nl/handle/1874/346086

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Canine hepacivirus and idiopathic hepatitis in dogs from a Dutch cohort

Autor: van der Laan, L J W, de Ruiter, P E, van Gils, I M, Fieten, H, Spee, B, Pan, Q, Rothuizen, J, Penning, L C, Universitair Veterinair Diagnostisch Lab, LS Interne geneeskunde, Onderzoek, CSCA TR1, CSCA AVM, Advances in Veterinary Medicine, Tissue Repair

Publikováno v: Journal of Viral Hepatitis, 21(12), 894-896. Wiley-Blackwell Publishing Ltd
Journal of Viral Hepatitis, 21(12), 894. Wiley-Blackwell

Liver diseases are highly prevalent in the general dog population, though the etiology is often unknown. Recently a homolog of human hepatitis C virus was discovered in dogs with respiratory infections. Although this canine hepacivirus (CHV) was dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8961370f13bffe9b247ecd4b3605f22
https://hdl.handle.net/1765/63582

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Intraspecies disparity in growth rate is associated with differences in expression of local growth plate regulators

Autor: Tryfonidou, M A, Hazewinkel, H A W, Riemers, F M, Brinkhof, B, Penning, L C, Karperien, M, Onderzoek, Sub Neuro/Tandheelkunde, Biochemisch laboratorium, Sub Celbiologisch lab.

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism, 299(6), 1044. American Physiological Society

Disparities in longitudinal growth within a species can be partly explained by endocrinological differences. We hypothesized that regulatory networks acting locally in the growth plate may also be important. We tested this hypothesis by evaluating th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7044f014be2d2f97b46f0ca8fcc2795c
https://doi.org/10.1152/ajpendo.00170.2010

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