NFκB signaling drives myocardial injury via CCR2⁺ macrophages in a preclinical model of arrhythmogenic cardiomyopathy.

Autor: Chelko, Stephen P.^1,2 stephen.chelko@med.fsu.edu, Penna, Vinay R.³, Engel, Morgan¹, Shiel, Emily A.¹, Centner, Ann M.¹, Farra, Waleed¹, Cannon, Elisa N.¹, Landim-Vieira, Maicon¹, Schaible, Niccole⁴, Lavine, Kory³, Saffitz, Jeffrey E.⁴

Publikováno v: Journal of Clinical Investigation. 5/15/2024, Vol. 134 Issue 10, p1-15. 15p.

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Hypoxia sensing in resident cardiac macrophages regulates monocyte fate specification following ischemic heart injury.

Autor: Kadyrov FF; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Koenig AL; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Amrute JM; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Dun H; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA., Li W; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA., Weinheimer CJ; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Nigro JM; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Kovacs A; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Bredemeyer AL; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Yang S; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Das S; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Penna VR; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Parvathaneni A; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Lai L; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Hartmann N; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.; German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg, Heidelberg, Germany.; Department of Cardiology, Internal Medicine III, Heidelberg University Hospital, Heidelberg, Germany., Kopecky BJ; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA., Kreisel D; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA., Lavine KJ; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA. klavine@wustl.edu.; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA. klavine@wustl.edu.; Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO, USA. klavine@wustl.edu.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2024 Nov; Vol. 3 (11), pp. 1337-1355. Date of Electronic Publication: 2024 Oct 21.