Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Penke, Melanie"'
Autor:
Garten, Antje, Grohmann, Theresa, Klockova, Katarina, Lavery, Gareth G., Kiess, Wieland, Penke, Melanie
Sorafenib is a multi-kinase inhibitor and one of the few systemic treatment options for patients with advanced hepatocellular carcinomas (HCCs). Resistance to sorafenib develops frequently and could be mediated by the nicotinamide adenine dinucleotid
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A89543
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https://ul.qucosa.de/api/qucosa%3A89543/attachment/ATT-0/
Autor:
Kirstein, Anna S., Augustin, Adrien, Penke, Melanie, Cea, Michele, Körner, Antje, Kiess, Wieland, Garten, Antje
Germline mutations in the tumor suppressor gene PTEN cause PTEN Hamartoma Tumor Syndrome (PHTS). Pediatric patients with PHTS frequently develop lipomas. Treatment attempts with the mTORC1 inhibitor rapamycin were unable to reverse lipoma growth. Rec
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A84609
https://ul.qucosa.de/api/qucosa%3A84609/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A84609/attachment/ATT-0/
Autor:
Kässner, Franziska, Sauer, Tina, Penke, Melanie, Richter, Sandy, Landgraf, Kathrin, Körner, Antje, Kiess, Wieland, Händel, Norman, Garten, Antje
Adipose tissue tumors (lipomas) frequently develop in patients with heterozygous germ line phosphatase and tensin homolog (PTEN) mutations. simvastatin has been demonstrated to exhibit antitumor effects, and so the aim of the present study was to ass
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A38594
https://ul.qucosa.de/api/qucosa%3A38594/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A38594/attachment/ATT-0/
Autor:
Grohmann, Theresa, Penke, Melanie, Petzold-Quinque, Stefanie, Schuster, Susanne, Richter, Sandy, Kiess, Wieland, Garten, Antje
NAMPT (Nicotinamide phosphoribosyltransferase) catalyses the rate-limiting step in the NAD biosynthesis from nicotinamide and thereby regulates the activity of NAD-dependent enzymes. Cancer cells are highly dependent on NAD for energy and DNA repair
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A38590
https://ul.qucosa.de/api/qucosa%3A38590/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A38590/attachment/ATT-0/
Autor:
Dall, Morten, Penke, Melanie, Sulek, Karolina, Matz-Soja, Madlen, Holst, Birgitte, Garten, Antje, Kiess, Wieland, Treebak, Jonas T.
Dietary supplementation of nicotinamide adenine dinucleotide (NAD+) precursors has been suggested as a treatment for non-alcoholic fatty liver disease and obesity. In the liver, NAD+ is primarily generated by nicotinamide phosphoribosyltransferase (N
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A38589
https://ul.qucosa.de/api/qucosa%3A38589/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A38589/attachment/ATT-0/
Could NAMPT inhibition become a potential treatment option in hepatocellular carcinoma?
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A38588
https://ul.qucosa.de/api/qucosa%3A38588/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A38588/attachment/ATT-0/
Autor:
Penke, Melanie, Larsen, Per S., Schuster, Susanne, Dall, Morten, Jensen, Benjamin A.H., Gorski, Theresa, Meusel, Andrej, Richter, Sandy, Vienberg, Sara G., Treebak, Jonas T., Kiess, Wieland, Garten, Antje
Nicotinamide phosphoribosyltransferase (Nampt) is the rate-limiting enzyme for NAD salvage and the abundance of Nampt has been shown to be altered in non-alcoholic fatty liver disease. It is, however, unknown how hepatic Nampt is regulated in respons
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A38585
https://ul.qucosa.de/api/qucosa%3A38585/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A38585/attachment/ATT-0/
Autor:
Schuster, Susanne, Penke, Melanie, Gorski, Theresa, Gebhardt, Rolf, Weiss, Thomas S., Kiess, Wieland, Garten, Antje
Background: Nicotinamide phosphoribosyltransferase (NAMPT) is the key enzyme of the NAD salvage pathway starting from nicotinamide. Cancer cells have an increased demand for NAD due to their high proliferation and DNA repair rate. Consequently, NAMPT
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A38584
https://ul.qucosa.de/api/qucosa%3A38584/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A38584/attachment/ATT-0/
Autor:
Penke, Melanie
Non-alcoholic fatty liver disease (NAFLD) is a major chronic liver disease and thus a main reason for liver-related morbidities and mortality. NAFLD covers a wide range of diseases starting with steatosis and frequently progressing to non-alcoholic s
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A14309
https://ul.qucosa.de/api/qucosa%3A14309/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A14309/attachment/ATT-0/
Autor:
Kirstein, Anna S., Kehr, Stephanie, Nebe, Michèle, Hanschkow, Martha, Barth, Lisa A.G., Lorenz, Judith, Penke, Melanie, Breitfeld, Jana, Le Duc, Diana, Landgraf, Kathrin, Körner, Antje, Kovacs, Peter, Stadler, Peter F., Kiess, Wieland, Garten, Antje
Publikováno v:
In Journal of Biological Chemistry August 2021 297(2)
