Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Penka S. Petrova"'
Autor:
Robert A. Uger, Jean C.Y. Wang, Liqing Jin, Nathan Mbong, Suzanne Trudel, James Koropatnick, Macarena Pampillo, Rene Figueredo, Saman Maleki Vareki, Eric L. Sievers, Emma Linderoth, Lisa D. Johnson, Stephane Viau, Tran Truong, Marilyse Charbonneau, Tapfuma Mutukura, Debbie Jin, Noel T. Vigo, Violetta House, Vivian Lee, Hui Chen, Vien Chai, Karen Dodge, Gloria H.Y. Lin, Xinli Pang, Mark Wong, Natasja Nielsen Viller, Penka S. Petrova
This figure shows our gating strategy and representative dot plots for our flow cytometry-based phagocytosis assay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6502221f8e80340a26b595d5b018332
https://doi.org/10.1158/1078-0432.22466546
https://doi.org/10.1158/1078-0432.22466546
Autor:
Robert A. Uger, Jean C.Y. Wang, Liqing Jin, Nathan Mbong, Suzanne Trudel, James Koropatnick, Macarena Pampillo, Rene Figueredo, Saman Maleki Vareki, Eric L. Sievers, Emma Linderoth, Lisa D. Johnson, Stephane Viau, Tran Truong, Marilyse Charbonneau, Tapfuma Mutukura, Debbie Jin, Noel T. Vigo, Violetta House, Vivian Lee, Hui Chen, Vien Chai, Karen Dodge, Gloria H.Y. Lin, Xinli Pang, Mark Wong, Natasja Nielsen Viller, Penka S. Petrova
These four supplementary tables summarize the following: Supplementary Table 1. TTI-621 binding to human tumor cell lines Supplementary Table 2. TTI-621 binding to human primary tumor samples Supplementary Table 3. TTI-621 binding to peripheral blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f89a4b999cc379fed7b6c4fbda99d25
https://doi.org/10.1158/1078-0432.22466540
https://doi.org/10.1158/1078-0432.22466540
Autor:
Owen A. O'Connor, Yaping Shou, Kathleen Roberge, Anca Milea, Eric L. Sievers, Robert A. Uger, Penka S. Petrova, Tina Catalano, Lisa D.S. Johnson, Oleg E. Akilov, Christiane Querfeld, Kerry J. Savage, Jasmine Zain, Matthew G. Mei, Steven M. Horwitz, James M. Foran, Anjali S. Advani, Mary-Elizabeth M. Percival, Diego Villa, Mark D. Minden, Ahmed Sawas, Ian W. Flinn, Robert W. Chen, Alexander M. Lesokhin, Michael B. Maris, Stephen M. Ansell
Study Schema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281c50bb0e69ede50363e21f4afa6737
https://doi.org/10.1158/1078-0432.22482851.v1
https://doi.org/10.1158/1078-0432.22482851.v1
Autor:
Owen A. O'Connor, Yaping Shou, Kathleen Roberge, Anca Milea, Eric L. Sievers, Robert A. Uger, Penka S. Petrova, Tina Catalano, Lisa D.S. Johnson, Oleg E. Akilov, Christiane Querfeld, Kerry J. Savage, Jasmine Zain, Matthew G. Mei, Steven M. Horwitz, James M. Foran, Anjali S. Advani, Mary-Elizabeth M. Percival, Diego Villa, Mark D. Minden, Ahmed Sawas, Ian W. Flinn, Robert W. Chen, Alexander M. Lesokhin, Michael B. Maris, Stephen M. Ansell
Purpose:TTI-621 (SIRPα-IgG1 Fc) is a novel checkpoint inhibitor that activates antitumor activity by blocking the CD47 “don't eat me” signal. This first-in-human phase I study (NCT02663518) evaluated the safety and activity of TTI-621 in relapse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6229d70998f979096284ba3849db926
https://doi.org/10.1158/1078-0432.c.6531017
https://doi.org/10.1158/1078-0432.c.6531017
Autor:
Robert A. Uger, Jean C.Y. Wang, Liqing Jin, Nathan Mbong, Suzanne Trudel, James Koropatnick, Macarena Pampillo, Rene Figueredo, Saman Maleki Vareki, Eric L. Sievers, Emma Linderoth, Lisa D. Johnson, Stephane Viau, Tran Truong, Marilyse Charbonneau, Tapfuma Mutukura, Debbie Jin, Noel T. Vigo, Violetta House, Vivian Lee, Hui Chen, Vien Chai, Karen Dodge, Gloria H.Y. Lin, Xinli Pang, Mark Wong, Natasja Nielsen Viller, Penka S. Petrova
This figure shows representative hematology data from non-human primates (cynomolgus monkeys) dosed with TTI-621.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708e5703f5001ec46eb1a5af14761411
https://doi.org/10.1158/1078-0432.22466543.v1
https://doi.org/10.1158/1078-0432.22466543.v1
Autor:
Robert A. Uger, Jean C.Y. Wang, Liqing Jin, Nathan Mbong, Suzanne Trudel, James Koropatnick, Macarena Pampillo, Rene Figueredo, Saman Maleki Vareki, Eric L. Sievers, Emma Linderoth, Lisa D. Johnson, Stephane Viau, Tran Truong, Marilyse Charbonneau, Tapfuma Mutukura, Debbie Jin, Noel T. Vigo, Violetta House, Vivian Lee, Hui Chen, Vien Chai, Karen Dodge, Gloria H.Y. Lin, Xinli Pang, Mark Wong, Natasja Nielsen Viller, Penka S. Petrova
Purpose: The ubiquitously expressed transmembrane glycoprotein CD47 delivers an anti-phagocytic (do not eat) signal by binding signal-regulatory protein α (SIRPα) on macrophages. CD47 is overexpressed in cancer cells and its expression is associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4d208603e1563c8d18005500a880ad
https://doi.org/10.1158/1078-0432.c.6526346.v1
https://doi.org/10.1158/1078-0432.c.6526346.v1
Autor:
Gloria H Y Lin, Vien Chai, Vivian Lee, Karen Dodge, Tran Truong, Mark Wong, Lisa D Johnson, Emma Linderoth, Xinli Pang, Jeff Winston, Penka S Petrova, Robert A Uger, Natasja N Viller
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0187262 (2017)
Tumor-associated macrophages (TAMs) are heterogeneous and can adopt a spectrum of activation states between pro-inflammatory and pro-tumorigenic in response to the microenvironment. We have previously shown that TTI-621, a soluble SIRPαFc fusion pro
Externí odkaz:
https://doaj.org/article/aa6dada1a604425b82ab93e1b3dc47f2
Autor:
Ian W. Flinn, Yaping Shou, Bob Uger, James M. Foran, Mary-Elizabeth M. Percival, Diego Villa, Kathleen Large, Catherine Diefenbach, Stephen M. Ansell, Youn H. Kim, Ahmed Sawas, Craig Okada, Kerry J. Savage, Gloria H. Y. Lin, Tatyana Feldman, Oleg E. Akilov, Steven M. Horwitz, Michael B. Maris, Lubomir Sokol, Mark D. Minden, Deepa Jagadeesh, Penka S. Petrova, Tina Catalano, Matthew Mei, Naomi Molloy
Publikováno v:
Blood. 136:41-43
Background CD47 is an innate immune checkpoint that binds signal regulatory protein alpha (SIRPα) and delivers a "do not eat" signal to suppress macrophage phagocytosis. Overexpression of CD47 can allow tumor cells to escape immune surveillance. TTI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f74fb340da5447e4b0bad7b1d9d8c56
https://doi.org/10.1182/blood-2020-136198
https://doi.org/10.1182/blood-2020-136198
Autor:
John A. Thompson, Carolyn Johns, Naomi Molloy, Penka S. Petrova, Jennifer DeSimone, Oleg E. Akilov, Gloria H. Y. Lin, Christiane Querfeld, Sue Ann McCann, Yaping Shou, Matthew H. Taylor, Andrei R. Shustov, Jasmine Zain, Robert A. Uger
Publikováno v:
The Lancet. Haematology. 8(11)
Summary Background Intravenous TTI-621 (SIRPα-IgG1 Fc) was previously shown to have activity in relapsed or refractory haematological malignancies. This phase 1 study evaluated the safety and activity of TTI-621 in patients with percutaneously acces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ab3c83e7305dcb53a2408aec7edb58
https://pubmed.ncbi.nlm.nih.gov/34627594
https://pubmed.ncbi.nlm.nih.gov/34627594
Autor:
Ahmed Sawas, Tina Catalano, Ian W. Flinn, Kathleen Roberge, Oleg E. Akilov, Mary Elizabeth Percival, Yaping Shou, Steven M. Horwitz, Mark D. Minden, Owen A. O'Connor, Anjali S. Advani, Penka S. Petrova, Stephen M. Ansell, Christiane Querfeld, Robert W. Chen, Anca Milea, James M. Foran, Eric L. Sievers, Robert A. Uger, Alexander M. Lesokhin, Lisa Johnson, Matthew Mei, Kerry J. Savage, Jasmine Zain, Diego Villa, Michael B. Maris
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 27(8)
Purpose: TTI-621 (SIRPα-IgG1 Fc) is a novel checkpoint inhibitor that activates antitumor activity by blocking the CD47 “don't eat me” signal. This first-in-human phase I study (NCT02663518) evaluated the safety and activity of TTI-621 in relaps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0222c62450e0850ec59e4b1c5e1bc748
https://pubmed.ncbi.nlm.nih.gov/33451977
https://pubmed.ncbi.nlm.nih.gov/33451977