Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Penio Pennev"'
Autor:
Thomas P. Maduskuie, Richard G. Wilde, Jeffrey T. Billheimer, Debra A. Cromley, Sandra Germain, Peter J. Gillies, C. Anne Higley, Alex L. Johnson, Penio Pennev, Edward J. Shimshick, Ruth R. Wexler
Publikováno v:
Journal of Medicinal Chemistry. 38:1067-1083
Acyl-CoA:cholesterol acyltransferase (ACAT) is the primary enzyme involved in intracellular cholesterol esterification. Arterial wall infiltration by macrophages and subsequent uncontrolled esterification of cholesterol leading to foam cell formation
Autor:
C.Y. Cheng, S.W. Tam, Parthasarathi Rajagopalan, Hollis Smith Kezar, Alexander L. Johnson, G.F. Steinfels, P.L. Mattei, Richard Merrill Scribner, R.S. Cheeseman, Penio Pennev, M. A. Wuonola, William K. Schmidt, V.R. Ganti, Leonard Cook
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:721-726
The results of a detailed study of the structure-activity relationships in the series of compounds represented by DuP 747 are described.
Autor:
S.W. Tam, Richard Merrill Scribner, G.F. Steinfels, Leonard Cook, Parthasarathi Rajagopalan, Penio Pennev, William K. Schmidt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:715-720
The synthesis and pharmacology of (±)-trans-3,4-dichloro-N-methyl-N-[5-methoxy-2-(pyrrolidin-1-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]benzeneacetamide methanesulfonate (DuP 747), a novel kappa agonist analgesic, are described.