Výsledky vyhledávání - "Penicillin-Binding Proteins/genetics"

The acquisition of clinically relevant amoxicillin resistance in Streptococcus pneumoniae requires ordered horizontal gene transfer of four loci

Autor: Paddy S. Gibson, Evan Bexkens, Sylvia Zuber, Lauren A. Cowley, Jan-Willem Veening

Publikováno v: PLoS pathogens, vol. 18, no. 7, pp. e1010727

Understanding how antimicrobial resistance spreads is critical for optimal application of new treatments. In the naturally competent human pathogen Streptococcus pneumoniae, resistance to β-lactam antibiotics is mediated by recombination events in g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1373dff457b1c9f65e024cf9051e7f
https://serval.unil.ch/resource/serval:BIB_05977A135425.P001/REF.pdf

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Detection of beta-lactamase-negative ampicillin resistance in Haemophilus influenzae in Belgium

Autor: Magali Wautier, Melissa Depypere, Lise Schotte, Delphine Martiny, Denis Pierard

Publikováno v: Diagnostic Microbiology and Infectious Disease. 93:243-249

Haemophilus influenzae, a frequent colonizer of the respiratory tract, is the causative agent of several clinically important infections. In cases that require therapeutic intervention, laboratory susceptibility testing can detect beta-lactam antibio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09ebb824b1ebcb9aa303b937cd43373
https://doi.org/10.1016/j.diagmicrobio.2018.10.009

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Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression

Autor: Oliver T. Carnell, Nikolay Zenkin, William L. Kelley, Bohdan Bilyk, Jeffrey Green, Viralkumar V. Panchal, Simon J. Foster, Jamie K. Hobbs, Joshua A. F. Sutton, Hamed Mosaei, David P. Hornby, Caitlin Griffiths

Publikováno v: PLoS Pathogens
PLOS Pathogens, Vol. 16, No 7 (2020) P. e1008672
PLoS Pathogens, Vol 16, Iss 7, p e1008672 (2020)

Most clinical MRSA (methicillin-resistant S. aureus) isolates exhibit low-level β-lactam resistance (oxacillin MIC 2–4 μg/ml) due to the acquisition of a novel penicillin binding protein (PBP2A), encoded by mecA. However, strains can evolve high-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956b4f17bd86062dc65d2eed9ac057c5
http://europepmc.org/articles/PMC7380596

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Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice

Autor: Harkins, Catriona P, Pichon, Bruno, Doumith, Michel, Parkhill, Julian, Westh, Henrik, Tomasz, Alexander, de Lencastre, Herminia, Bentley, Stephen D, Kearns, Angela M, Holden, Matthew TG

Publikováno v: Genome Biology, Vol 18, Iss 1, Pp 1-11 (2017)
Harkins, C P, Pichon, B, Doumith, M, Parkhill, J, Westh, H, Tomasz, A, de Lencastre, H, Bentley, S D, Kearns, A M & Holden, M T G 2017, ' Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice ', Genome Biology (Online Edition), vol. 18, 130 . https://doi.org/10.1186/s13059-017-1252-9
Genome Biology

SDB, JP and MTGH were supported by Wellcome Trust grant 098051. CPH was supported by Wellcome Trust grant number 104241/z/14/z. Bioinformatics and computational biology analyses were supported by the University of St Andrews Bioinformatics Unit, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1c5b8daa79668f8b22c9cb38e8542d9f
http://link.springer.com/article/10.1186/s13059-017-1252-9

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The TIR Homologue Lies near Resistance Genes in Staphylococcus aureus, Coupling Modulation of Virulence and Antimicrobial Susceptibility

Autor: Jacques Schrenzel, Adrien Nicolas Fischer, Reindert Nijland, Arthur Louche, Anne Tristan, Sabine Patot, Patrice Francois, François Vandenesch, Jessica Baude, Suzana P. Salcedo, Gerard Lina, Paul R. C. Imbert, Michèle Bes, Jean-Baptiste Campergue, Patricia Martins Simoes, Frédéric Laurent

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2017, 13 (1), pp.e1006092. ⟨10.1371/journal.ppat.1006092⟩
PLoS Pathogens 13 (2017) 1
PLOS Pathogens, Vol. 13, No 1 (2017) P. e1006092
PLoS Pathogens, Vol 13, Iss 1, p e1006092 (2017)
PLoS Pathogens, 2017, 13 (1), pp.e1006092. ⟨10.1371/journal.ppat.1006092⟩
PLoS Pathogens, 13(1)

Toll/interleukin-1 receptor (TIR) domains in Toll-like receptors are essential for initiating and propagating the eukaryotic innate immune signaling cascade. Here, we investigate TirS, a Staphylococcus aureus TIR mimic that is part of a novel bacteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d592b332b5aa4045c31208f6606ed5e2
https://doi.org/10.1371/journal.ppat.1006092

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Antimicrobial activity of ceftaroline against methicillin-resistant Staphylococcus aureus (MRSA) isolates collected in 2013-2014 at the Geneva University Hospitals

Autor: Diego O. Andrey, Jacques Schrenzel, Patrice Francois, C. Manzano, Adriana Renzoni, William L. Kelley, Stéphan Juergen Harbarth, Eve-Julie Bonetti

Publikováno v: European Journal of Clinical Microbiology & Infectious Diseases, Vol. 36, No 2 (2017) pp. 343-350
European journal of clinical microbiology & infectious diseases : official publication of the Europe
European Journal of Clinical Microbiology & Infectious Diseases

Ceftaroline is a broad-spectrum antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA) strains. Ceftaroline susceptibility of an MRSA set archived between 1994 and 2003 in the Geneva University Hospitals detected a high p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7dee1ec54eea71c86880a94ef23e6b
https://archive-ouverte.unige.ch/unige:98886

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Low β-Lactamase-Negative Ampicillin-Resistant Haemophilus influenzae Strains Are Best Detected by Testing Amoxicillin Susceptibility by the Broth Microdilution Method

Autor: María Pérez-Vázquez, Cristina Carrera, Belén Aracil, José Campos, Federico Román, Silvia García-Cobos, Jesús Oteo

Publikováno v: Antimicrobial Agents and Chemotherapy, 52(7), 2407-2414. AMER SOC MICROBIOLOGY

Ampicillin resistance in Haemophilus influenzae due to alterations in penicillin-binding proteins (β-lactamase negative ampicillin resistant [BLNAR]) is acquiring increasing clinical and epidemiological importance. BLNAR strains with low ampicillin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8677ada68a1f32bd8ae44769002d553
https://doi.org/10.1128/aac.00214-08

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Excision of staphylococcal cassette chromosome mec in methicillin-resistant Staphylococcus aureus assessed by quantitative PCR

Autor: Olga Sakwinska, Philippe Moreillon, Milos Stojanov

Publikováno v: Bmc Research Notes, vol. 8, pp. 828
BMC Research Notes

Background Methicillin-resistance in staphylococci is conferred by the mecA gene, located on the genomic island Staphylococcal Cassette Chromosome mec (SCCmec). SCCmec mobility relies on the Ccr recombinases, which catalyze insertion and excision for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b9fca8e71c4f76fe7c7d5eb731deca
https://doi.org/10.1186/s13104-015-1815-3

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Isolates of β-lactamase-negative ampicillin-resistant Haemophilus influenzae causing invasive infections in Spain remain susceptible to cefotaxime and imipenem

Autor: Belén Aracil, Emilia Cercenado, María Pérez-Vázquez, Noelia Lara, José Campos, Margarita Arroyo, Silvia García-Cobos, Jesús Oteo

Publikováno v: Journal of Antimicrobial Chemotherapy, 69(1), 111-116. Oxford University Press

OBJECTIVES: The epidemiology of invasive Haemophilus influenzae has changed in recent years. β-Lactamase-negative ampicillin-resistant (BLNAR) invasive isolates have recently been described in Europe but their clinical significance is unclear. Our m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e4f49c0f1e4b9c029b0e206e027405
https://pubmed.ncbi.nlm.nih.gov/23943391

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Novel mechanisms of resistance to β-lactam antibiotics in Haemophilus parainfluenzae: β-lactamase-negative ampicillin resistance and inhibitor-resistant TEM β-lactamases

Autor: José Campos, Noelia Lara, Belén Aracil, Emilia Cercenado, Silvia García-Cobos, Jesús Oteo, Beatriz Orden, María Pérez-Vázquez, Margarita Arroyo

Publikováno v: Journal of Antimicrobial Chemotherapy, 68(5), 1054-1059. Oxford University Press

OBJECTIVES: To determine the mechanisms of resistance to β-lactam antibiotics in clinical isolates of Haemophilus parainfluenzae.METHODS: Twenty clinical isolates of H. parainfluenzae with decreased susceptibility to aminopenicillins were examined a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d861a2fb6e75079d208e6d4467f8eee6
https://pubmed.ncbi.nlm.nih.gov/23335113

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