NANOG Is Multiply Phosphorylated and Directly Modified by ERK2 and CDK1 In Vitro

Autor: Justin Brumbaugh, Jason D. Russell, Pengzhi Yu, Michael S. Westphall, Joshua J. Coon, James A. Thomson

Publikováno v: Stem Cell Reports, Vol 2, Iss 1, Pp 18-25 (2014)

NANOG is a divergent homeobox protein and a core component of the transcriptional circuitry that sustains pluripotency and self-renewal. Although NANOG has been extensively studied on the transcriptional level, little is known regarding its posttrans

Externí odkaz: https://doaj.org/article/3cdff99f7e004eb9a0faa2a15bea5c2e

Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming

Autor: Reuben Thomas, Karishma Pratt, Kaitlen Samse-Knapp, Lin Ye, Ethan Radzinsky, Joke G. van Bemmel, Nicole Stone, Kathryn N. Ivey, Casey A. Gifford, Amelia Schricker, Tamer M.A. Mohamed, Pengzhi Yu, Deepak Srivastava, Katherine S. Pollard

Publikováno v: Cell stem cell, vol 25, iss 1
Cell Stem Cell
Stone, N R, Gifford, C A, Thomas, R, Pratt, K J B, Samse-Knapp, K, Mohamed, T M A, Radzinsky, E M, Schricker, A, Ye, L, Yu, P, van Bemmel, J G, Ivey, K N, Pollard, K S & Srivastava, D 2019, ' Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming ', Cell Stem Cell, vol. 25, no. 1, pp. 87-102.e9 . https://doi.org/10.1016/j.stem.2019.06.012

Ectopic expression of combinations of transcription factors (TFs) can drive direct lineage conversion, thereby reprogramming a somatic cell's identity. To determine the molecular mechanisms by which Gata4, Mef2c, and Tbx5 (GMT) induce conversion from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d33d2776d4d5a4bda36294362c2e3b
https://escholarship.org/uc/item/5063d4vp

Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming

Autor: Shibing Tang, Haixia Wang, Nicole Stone, Deepak Srivastava, Kathryn N. Ivey, Ethan Radzinsky, Pengzhi Yu, Emily C. Berry, Sergey Magnitsky, Karishma Pratt, Tamer M.A. Mohamed, Sheng Ding, Yu Huang, Yen-Sin Ang

Publikováno v: Circulation, vol 135, iss 10
Mohamed, T M A, Stone, N R, Berry, E C, Radzinsky, E, Huang, Y, Pratt, K, Ang, Y-S, Yu, P, Wang, H, Tang, S, Magnitsky, S, Ding, S, Ivey, K N & Srivastava, D 2016, ' Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming ', Circulation . https://doi.org/10.1161/CIRCULATIONAHA.116.024692

Background: Reprogramming of cardiac fibroblasts into induced cardiomyocyte-like cells in situ represents a promising strategy for cardiac regeneration. A combination of 3 cardiac transcription factors, Gata4, Mef2c, and Tbx5 (GMT), can convert fibro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a75ee54d4603e834fde952339e1a4f5
https://escholarship.org/uc/item/0mz0485j

Instant spectral assignment for advanced decision tree-driven mass spectrometry

Autor: Joshua J. Coon, Michael S. Westphall, Craig D. Wenger, Graeme C. McAlister, James A. Thomson, Christopher M. Rose, Justin Brumbaugh, Pengzhi Yu, Derek J. Bailey

Publikováno v: Proceedings of the National Academy of Sciences. 109:8411-8416

We have developed and implemented a sequence identification algorithm ( inSeq ) that processes tandem mass spectra in real-time using the mass spectrometer’s (MS) onboard processors. The inSeq algorithm relies on accurate mass tandem MS data for sw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63652ebdec7b84611f68c69880628cf
https://doi.org/10.1073/pnas.1205292109

On the evolution of Linux kernels: a complex network perspective

Autor: Pengzhi Yu, Chen Yang, Lei Wang, Qiang Ye, Zheng Wang

Publikováno v: Journal of Software: Evolution and Process. 25:439-458

SUMMARY This paper presents a novel method to study the evolution of Linux kernel components using complex networks to understand how Linux kernel components evolve over time. After analyzing the node degree distribution, clustering coefficient, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bacf08656a9b46a1716946b6aee7acf1
https://doi.org/10.1002/smr.1550