Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Pengzhen Wang"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Although there has been some progress in the treatment of primary uveal melanoma (UVM), distant metastasis remains the leading cause of death in patients. Monitoring, staging, and treatment of metastatic disease have not yet reach
Externí odkaz:
https://doaj.org/article/c1ee2476737d4e0e849983ebc87a1cbd
Autor:
Kang Qian, Peng Yang, Yixian Li, Ran Meng, Yunlong Cheng, Lingling Zhou, Jing Wu, Shuting Xu, Xiaoyan Bao, Qian Guo, Pengzhen Wang, Minjun Xu, Dongyu Sheng, Qizhi Zhang
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 19, Iss 4, Pp 100938- (2024)
Alzheimer's disease is a neurodegenerative disease induced by multiple interconnected mechanisms. Peptide drug candidates with multi-modal efficacy generated from fusion strategy are suitable for addressing multi-facet pathology. However, clinical tr
Externí odkaz:
https://doaj.org/article/403f74994e394d2e9ed2d13b852fc61f
Autor:
Yixian Li, Peng Yang, Ran Meng, Shuting Xu, Lingling Zhou, Kang Qian, Pengzhen Wang, Yunlong Cheng, Dongyu Sheng, Minjun Xu, Tianying Wang, Jing Wu, Jinxu Cao, Qizhi Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1380-1399 (2024)
Intraneuronal dysproteostasis and extraneuronal microenvironmental abnormalities in Alzheimer's disease (AD) collectively culminate in neuronal deterioration. In the context of AD, autophagy dysfunction, a multi-link obstacle involving autophagy down
Externí odkaz:
https://doaj.org/article/8bd04ee938174169b40471e454fdf68d
Autor:
Jian Wu, Yifang Sun, Qian Zhang, Ying Lin, Pengzhen Wang, Lei Leng, Lei Cao, Feng Yu, Haiyan Deng
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
BackgroundParathyroid carcinoma is an infrequent neoplasm of the endocrine system, constituting roughly 0.5% to 5% of cases of primary hyperparathyroidism. The diagnosis of this condition presents a unique challenge for healthcare professionals.Case
Externí odkaz:
https://doaj.org/article/d091b019492c420e893c7245407875a4
Publikováno v:
PeerJ, Vol 11, p e15917 (2023)
Icariin (ICA) is a typical flavonoid glycoside derived from epimedium plants. It has both anabolic and anti-catabolic effects to improve bone mineral density and reduce bone microstructural degradation. However, the effect and underlying mechanism of
Externí odkaz:
https://doaj.org/article/be86a7611b0e4701b5eaaf32034f9e65
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-27 (2022)
Abstract Background Cardiac-resident mesenchymal stem cells (cMSCs) can exhibit fibrotic, proinflammatory, and proangiogenic phenotype in response to myocardial ischemia (Isch). How their phenotypic fate decisions are determined remains poorly unders
Externí odkaz:
https://doaj.org/article/7dcc3384fdb84e0bbbbf45d6677045a2
Autor:
Shuting Xu, Peng Yang, Kang Qian, Yixian Li, Qian Guo, Pengzhen Wang, Ran Meng, Jing Wu, Jinxu Cao, Yunlong Cheng, Minjun Xu, Qizhi Zhang
Publikováno v:
Bioactive Materials, Vol 11, Iss , Pp 300-316 (2022)
Compromised autophagy and defective lysosomal clearance significantly contribute to impaired neuronal proteostasis, which represents a hallmark of Alzheimer's disease (AD) and other age-related neurodegenerative disorders. Growing evidence has implic
Externí odkaz:
https://doaj.org/article/38cdd5f5995b4da78d49ad7b81c7193b
Autor:
Bei Zhang, Shanyong Mao, Xingde Liu, Sha Li, Haiyan Zhou, Ying Gu, Wupeng Liu, Lei Fu, Chunyan Liao, Pengzhen Wang
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-12 (2021)
Abstract Background Although miR-125b plays a crucial role in many human cancers. However, its function in heart failure (HF) remains unclear. Our study aimed to investigate its involvement in heart failure. Methods In this study, the mouse HF model
Externí odkaz:
https://doaj.org/article/e14a6ab41d9c4672b3c62f4dcee766a6
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
This study aimed to address the dilemma of low peripheral blood-derived mesenchymal stromal cell (PBMSC) activity and reduced phenotype in bone or cartilage tissue engineering. Rat PBMSCs (rPBMSCs) were obtained by density gradient centrifugation, an
Externí odkaz:
https://doaj.org/article/0dce6ccc56af4c0d96beae626405c125
Autor:
Shengnan Qin, Wen Wang, Zhihe Liu, Xing Hua, SaiChuen Fu, Fei Dong, Aiguo Li, Zhen Liu, Pengzhen Wang, Libing Dai, Peihong Liang, Jinli Zhang, Wenjuan Cao, Xifeng Xiong, Honghui Chen, Jiake Xu
Publikováno v:
Journal of Orthopaedic Translation, Vol 22, Iss , Pp 101-108 (2020)
Background: Bone–tendon junction (BTJ) is a unique structure connecting tendon and bone through a fibrocartilage zone. Owing to its unique structure, the regeneration of BTJ remains a challenge. Here, we study the fibrochondrogenic differentiation
Externí odkaz:
https://doaj.org/article/5d8f5069b2e042769b1c810aa51fe8ee